Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results

Detalhes bibliográficos
Autor(a) principal: Melo, Miguel
Data de Publicação: 2021
Outros Autores: Gavina, Cristina, Silva-Nunes, José, Andrade, Luís, Carvalho, Davide
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/124269
Resumo: Funding Information: MM participated in advisory board meetings and received speaker’s fees from the following companies: AstraZeneca, Bial, Boeringher-Ingelheim, Lilly, NovoNordisk and Sanofi. CG reports consulting and speaking fees from Astrazeneca, Novo Nordisk, Lilly, Boheringer Ingelheim, MSD and Bayer. JSN reports receiving research funding from AstraZeneca, and Merck sa; and consulting/speaker’s fees from Abbott, AstraZeneca, Bial, Boehringer Ingelheim, Janssen, Lilly, Medinfar, Merck sa, Merck Sharp & Dohme, Mundipharma, Novartis, Novo Nordisk, Roche, Sanofi, Servier, Tecnimede. LA reports membership of advisory board, consultancy/ speaker's fees from: Astra-Zeneca, Lilly, Bhoeringer, NovoNordisk and Bial.DC is member of Advisory Boards of Novo-Nordisk, Astra-Zeneca, Eli Lilly, Sanofi-Aventis and is speaker for Novo-Nordisk, Astra-Zeneca, Eli Lilly. Publisher Copyright: © 2021, The Author(s).
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spelling Heterogeneity amongst GLP-1 RA cardiovascular outcome trials resultscan definition of established cardiovascular disease be the missing link?Antidiabetic drugCardiovascular diseaseCardiovascular outcome trialsGLP-1 RAType 2 diabetesInternal MedicineEndocrinology, Diabetes and MetabolismSDG 3 - Good Health and Well-beingFunding Information: MM participated in advisory board meetings and received speaker’s fees from the following companies: AstraZeneca, Bial, Boeringher-Ingelheim, Lilly, NovoNordisk and Sanofi. CG reports consulting and speaking fees from Astrazeneca, Novo Nordisk, Lilly, Boheringer Ingelheim, MSD and Bayer. JSN reports receiving research funding from AstraZeneca, and Merck sa; and consulting/speaker’s fees from Abbott, AstraZeneca, Bial, Boehringer Ingelheim, Janssen, Lilly, Medinfar, Merck sa, Merck Sharp & Dohme, Mundipharma, Novartis, Novo Nordisk, Roche, Sanofi, Servier, Tecnimede. LA reports membership of advisory board, consultancy/ speaker's fees from: Astra-Zeneca, Lilly, Bhoeringer, NovoNordisk and Bial.DC is member of Advisory Boards of Novo-Nordisk, Astra-Zeneca, Eli Lilly, Sanofi-Aventis and is speaker for Novo-Nordisk, Astra-Zeneca, Eli Lilly. Publisher Copyright: © 2021, The Author(s).Atherosclerotic cardiovascular diseases are the leading cause of adverse outcomes in patients with type 2 diabetes, and all new anti-diabetic agents are mandated to undergo cardiovascular outcome trials (CVOTs). Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are incretin mimetics that reduce blood glucose levels with a low associated risk of hypoglycaemia. CVOTs with different GLP-1 RAs yielded different results in terms of major cardiovascular composite outcome (MACE), with some trials showing superiority in the treatment arm, whereas other simply displayed non-inferiority. More importantly, the significance of each component of MACE varied between drugs. This begs the question of whether these differences are due to dissimilarities between drugs or other factors, namely trial design, are at the root of these differences. We analyse the trial designs for all CVOTs with GLP-1 RAs and highlight important differences between them, namely in terms of definition of established cardiovascular disease, and discuss how these differences might explain the disparate results of the trials and preclude direct comparisons between them. We conclude that a fair comparison between GLP-1 RA CVOTs would involve post-hoc analysis re-grouping the patients into different cardiovascular risk categories based upon their baseline clinical parameters, in order to even out the criteria used to classify patients.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMelo, MiguelGavina, CristinaSilva-Nunes, JoséAndrade, LuísCarvalho, Davide2021-09-09T00:27:39Z2021-07-272021-07-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/124269engPURE: 33428612https://doi.org/10.1186/s13098-021-00698-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:55:58Zoai:run.unl.pt:10362/124269Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:55:58Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results
can definition of established cardiovascular disease be the missing link?
title Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results
spellingShingle Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results
Melo, Miguel
Antidiabetic drug
Cardiovascular disease
Cardiovascular outcome trials
GLP-1 RA
Type 2 diabetes
Internal Medicine
Endocrinology, Diabetes and Metabolism
SDG 3 - Good Health and Well-being
title_short Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results
title_full Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results
title_fullStr Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results
title_full_unstemmed Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results
title_sort Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results
author Melo, Miguel
author_facet Melo, Miguel
Gavina, Cristina
Silva-Nunes, José
Andrade, Luís
Carvalho, Davide
author_role author
author2 Gavina, Cristina
Silva-Nunes, José
Andrade, Luís
Carvalho, Davide
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Melo, Miguel
Gavina, Cristina
Silva-Nunes, José
Andrade, Luís
Carvalho, Davide
dc.subject.por.fl_str_mv Antidiabetic drug
Cardiovascular disease
Cardiovascular outcome trials
GLP-1 RA
Type 2 diabetes
Internal Medicine
Endocrinology, Diabetes and Metabolism
SDG 3 - Good Health and Well-being
topic Antidiabetic drug
Cardiovascular disease
Cardiovascular outcome trials
GLP-1 RA
Type 2 diabetes
Internal Medicine
Endocrinology, Diabetes and Metabolism
SDG 3 - Good Health and Well-being
description Funding Information: MM participated in advisory board meetings and received speaker’s fees from the following companies: AstraZeneca, Bial, Boeringher-Ingelheim, Lilly, NovoNordisk and Sanofi. CG reports consulting and speaking fees from Astrazeneca, Novo Nordisk, Lilly, Boheringer Ingelheim, MSD and Bayer. JSN reports receiving research funding from AstraZeneca, and Merck sa; and consulting/speaker’s fees from Abbott, AstraZeneca, Bial, Boehringer Ingelheim, Janssen, Lilly, Medinfar, Merck sa, Merck Sharp & Dohme, Mundipharma, Novartis, Novo Nordisk, Roche, Sanofi, Servier, Tecnimede. LA reports membership of advisory board, consultancy/ speaker's fees from: Astra-Zeneca, Lilly, Bhoeringer, NovoNordisk and Bial.DC is member of Advisory Boards of Novo-Nordisk, Astra-Zeneca, Eli Lilly, Sanofi-Aventis and is speaker for Novo-Nordisk, Astra-Zeneca, Eli Lilly. Publisher Copyright: © 2021, The Author(s).
publishDate 2021
dc.date.none.fl_str_mv 2021-09-09T00:27:39Z
2021-07-27
2021-07-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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url http://hdl.handle.net/10362/124269
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 33428612
https://doi.org/10.1186/s13098-021-00698-5
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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