Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.26/6427 |
Resumo: | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012Antiretroviral therapyHIV-1Highly-active antiretroviral therapyAdolescentsChildrenMadridThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published."Objectives: To investigate the duration of sequential HAART regimens and predictors of first-line regimen discontinuation among HIV-1 vertically infected children and adolescents. Design: Multicentre survey of antiretroviral-naı¨ve patients enrolled in the HIV-Paediatric Cohor,t CoRISpeS-Madrid Cohort, Spain. Methods: Patients with a follow-up of $1 month spent on HAART, with available baseline CD4 count and HIV-viral load (VL) were included. Time spent on sequential HAART regimens was estimated and multivariable regression was used to identify predictors of time to first-line regimen discontinuation. Results: 104 patients were followed for a median 8 years after starting HAART among 1996–2012; baseline %CD4 was 21.5 (12.3–34.0)and viral load was 5.1 (4.6–5.6) log10 copies/mL. Patients received a mean of 1.9 regimens. Median time on firstline HAART (n = 104) was 64.5 months; second HAART (n = 56) 69.8 months; and third HAART (n = 21) 66.5 months. Eleven (11%) patients were lost to follow-up while on first-line HAART and 54% discontinued (cumulative incidence of 16% and 38% by 1 and 3-year, respectively). The main predictor of first-line regimen discontinuation was suboptimal adherence to antiretrovirals (AHR: 2.60; 95% CI: 1.44–4.70). Conclusions: Adherence to therapy was the main determinant of the duration of the first-line HAART regimen in children. It is important to identify patients at high risk for non-adherence, such as very young children and adolescents, in provide special care and support to those patients."PLOSRepositório ComumPalladino, ClaudiaBriz, VerónicaBellón, José MaríaCliment, Francisco J.De Ory, Santiago J.Mellado, María JoséNavarro, María LuisaRamos, José T.Taveira, NunoDe José, María IsabelMunõz-Fernandes, María ÁngelesCoRISpeS-Madrid Cohort Working Group2014-05-29T12:00:32Z2014-052014-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/6427engPLoS ONE 9(5): e96307. doi:10.1371/journal.pone.00963071932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T02:30:54Zoai:comum.rcaap.pt:10400.26/6427Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:04.714970Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| spellingShingle |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 Palladino, Claudia Antiretroviral therapy HIV-1 Highly-active antiretroviral therapy Adolescents Children Madrid |
| title_short |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title_full |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title_fullStr |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title_full_unstemmed |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title_sort |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| author |
Palladino, Claudia |
| author_facet |
Palladino, Claudia Briz, Verónica Bellón, José María Climent, Francisco J. De Ory, Santiago J. Mellado, María José Navarro, María Luisa Ramos, José T. Taveira, Nuno De José, María Isabel Munõz-Fernandes, María Ángeles CoRISpeS-Madrid Cohort Working Group |
| author_role |
author |
| author2 |
Briz, Verónica Bellón, José María Climent, Francisco J. De Ory, Santiago J. Mellado, María José Navarro, María Luisa Ramos, José T. Taveira, Nuno De José, María Isabel Munõz-Fernandes, María Ángeles CoRISpeS-Madrid Cohort Working Group |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Comum |
| dc.contributor.author.fl_str_mv |
Palladino, Claudia Briz, Verónica Bellón, José María Climent, Francisco J. De Ory, Santiago J. Mellado, María José Navarro, María Luisa Ramos, José T. Taveira, Nuno De José, María Isabel Munõz-Fernandes, María Ángeles CoRISpeS-Madrid Cohort Working Group |
| dc.subject.por.fl_str_mv |
Antiretroviral therapy HIV-1 Highly-active antiretroviral therapy Adolescents Children Madrid |
| topic |
Antiretroviral therapy HIV-1 Highly-active antiretroviral therapy Adolescents Children Madrid |
| description |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-05-29T12:00:32Z 2014-05 2014-05-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/6427 |
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http://hdl.handle.net/10400.26/6427 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
PLoS ONE 9(5): e96307. doi:10.1371/journal.pone.0096307 1932-6203 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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PLOS |
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PLOS |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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