Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012

Detalhes bibliográficos
Autor(a) principal: Palladino, Claudia
Data de Publicação: 2014
Outros Autores: Briz, Verónica, Bellón, José María, Climent, Francisco J., De Ory, Santiago J., Mellado, María José, Navarro, María Luisa, Ramos, José T., Taveira, Nuno, De José, María Isabel, Munõz-Fernandes, María Ángeles, CoRISpeS-Madrid Cohort Working Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/6427
Resumo: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published.
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spelling Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012Antiretroviral therapyHIV-1Highly-active antiretroviral therapyAdolescentsChildrenMadridThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published."Objectives: To investigate the duration of sequential HAART regimens and predictors of first-line regimen discontinuation among HIV-1 vertically infected children and adolescents. Design: Multicentre survey of antiretroviral-naı¨ve patients enrolled in the HIV-Paediatric Cohor,t CoRISpeS-Madrid Cohort, Spain. Methods: Patients with a follow-up of $1 month spent on HAART, with available baseline CD4 count and HIV-viral load (VL) were included. Time spent on sequential HAART regimens was estimated and multivariable regression was used to identify predictors of time to first-line regimen discontinuation. Results: 104 patients were followed for a median 8 years after starting HAART among 1996–2012; baseline %CD4 was 21.5 (12.3–34.0)and viral load was 5.1 (4.6–5.6) log10 copies/mL. Patients received a mean of 1.9 regimens. Median time on firstline HAART (n = 104) was 64.5 months; second HAART (n = 56) 69.8 months; and third HAART (n = 21) 66.5 months. Eleven (11%) patients were lost to follow-up while on first-line HAART and 54% discontinued (cumulative incidence of 16% and 38% by 1 and 3-year, respectively). The main predictor of first-line regimen discontinuation was suboptimal adherence to antiretrovirals (AHR: 2.60; 95% CI: 1.44–4.70). Conclusions: Adherence to therapy was the main determinant of the duration of the first-line HAART regimen in children. It is important to identify patients at high risk for non-adherence, such as very young children and adolescents, in provide special care and support to those patients."PLOSRepositório ComumPalladino, ClaudiaBriz, VerónicaBellón, José MaríaCliment, Francisco J.De Ory, Santiago J.Mellado, María JoséNavarro, María LuisaRamos, José T.Taveira, NunoDe José, María IsabelMunõz-Fernandes, María ÁngelesCoRISpeS-Madrid Cohort Working Group2014-05-29T12:00:32Z2014-052014-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/6427engPLoS ONE 9(5): e96307. doi:10.1371/journal.pone.00963071932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T02:30:54Zoai:comum.rcaap.pt:10400.26/6427Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:04.714970Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
title Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
spellingShingle Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
Palladino, Claudia
Antiretroviral therapy
HIV-1
Highly-active antiretroviral therapy
Adolescents
Children
Madrid
title_short Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
title_full Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
title_fullStr Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
title_full_unstemmed Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
title_sort Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
author Palladino, Claudia
author_facet Palladino, Claudia
Briz, Verónica
Bellón, José María
Climent, Francisco J.
De Ory, Santiago J.
Mellado, María José
Navarro, María Luisa
Ramos, José T.
Taveira, Nuno
De José, María Isabel
Munõz-Fernandes, María Ángeles
CoRISpeS-Madrid Cohort Working Group
author_role author
author2 Briz, Verónica
Bellón, José María
Climent, Francisco J.
De Ory, Santiago J.
Mellado, María José
Navarro, María Luisa
Ramos, José T.
Taveira, Nuno
De José, María Isabel
Munõz-Fernandes, María Ángeles
CoRISpeS-Madrid Cohort Working Group
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Palladino, Claudia
Briz, Verónica
Bellón, José María
Climent, Francisco J.
De Ory, Santiago J.
Mellado, María José
Navarro, María Luisa
Ramos, José T.
Taveira, Nuno
De José, María Isabel
Munõz-Fernandes, María Ángeles
CoRISpeS-Madrid Cohort Working Group
dc.subject.por.fl_str_mv Antiretroviral therapy
HIV-1
Highly-active antiretroviral therapy
Adolescents
Children
Madrid
topic Antiretroviral therapy
HIV-1
Highly-active antiretroviral therapy
Adolescents
Children
Madrid
description This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published.
publishDate 2014
dc.date.none.fl_str_mv 2014-05-29T12:00:32Z
2014-05
2014-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/6427
url http://hdl.handle.net/10400.26/6427
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS ONE 9(5): e96307. doi:10.1371/journal.pone.0096307
1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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