No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain)
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/17730 |
Resumo: | The neurotoxin β-N-methylamino-L-alanine (BMAA), a non-proteinogenic amino acid produced by several species of both prokaryotic (cyanobacteria) and eukaryotic (diatoms) microorganisms, has been proposed to be associated with the development of neurodegenerative diseases. At first, BMAA appeared to be ubiquitously present worldwide in various organisms, from aquatic and terrestrial food webs. However, recent studies, using detection methods based on mass spectrometry, instead of fluorescence detection, suggest that the trophic transfer of BMAA is debatable. This study evaluated BMAA in 22 cetaceans of three different species (<i>Phocoena phocoena</i>, <i>n</i> = 8, <i>Delphinus delphis</i>, <i>n</i> = 8, and <i>Tursiops truncatus</i>, <i>n</i> = 6), found stranded in North-West Spain. BMAA analysis of the liver, kidney, or muscle tissues via sensitive liquid chromatography with tandem mass spectrometry did not reveal the presence of this compound or its isomers. The absence recorded in this study highlights the need to better understand the trophic transfer of BMAA and its anatomical distribution in marine mammals. |
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No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain)Marine mammalsPhycotoxinsHarmful algae bloomsBioaccumulationMarine food websAlzheimer diseaseThe neurotoxin β-N-methylamino-L-alanine (BMAA), a non-proteinogenic amino acid produced by several species of both prokaryotic (cyanobacteria) and eukaryotic (diatoms) microorganisms, has been proposed to be associated with the development of neurodegenerative diseases. At first, BMAA appeared to be ubiquitously present worldwide in various organisms, from aquatic and terrestrial food webs. However, recent studies, using detection methods based on mass spectrometry, instead of fluorescence detection, suggest that the trophic transfer of BMAA is debatable. This study evaluated BMAA in 22 cetaceans of three different species (<i>Phocoena phocoena</i>, <i>n</i> = 8, <i>Delphinus delphis</i>, <i>n</i> = 8, and <i>Tursiops truncatus</i>, <i>n</i> = 6), found stranded in North-West Spain. BMAA analysis of the liver, kidney, or muscle tissues via sensitive liquid chromatography with tandem mass spectrometry did not reveal the presence of this compound or its isomers. The absence recorded in this study highlights the need to better understand the trophic transfer of BMAA and its anatomical distribution in marine mammals.MDPISapientiaSoliño, LuciaKim, Sea-YongLópez, AlfredoCovelo, PabloRydberg, SaraReis Costa, PedroLage, Sandra2022-03-28T14:30:15Z2022-02-232022-03-24T14:47:07Z2022-02-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/17730engJournal of Marine Science and Engineering 10 (3): 314 (2022)2077-131210.3390/jmse10030314info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-13T02:07:11Zoai:sapientia.ualg.pt:10400.1/17730Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:07:36.710857Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain) |
title |
No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain) |
spellingShingle |
No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain) Soliño, Lucia Marine mammals Phycotoxins Harmful algae blooms Bioaccumulation Marine food webs Alzheimer disease |
title_short |
No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain) |
title_full |
No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain) |
title_fullStr |
No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain) |
title_full_unstemmed |
No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain) |
title_sort |
No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain) |
author |
Soliño, Lucia |
author_facet |
Soliño, Lucia Kim, Sea-Yong López, Alfredo Covelo, Pablo Rydberg, Sara Reis Costa, Pedro Lage, Sandra |
author_role |
author |
author2 |
Kim, Sea-Yong López, Alfredo Covelo, Pablo Rydberg, Sara Reis Costa, Pedro Lage, Sandra |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Soliño, Lucia Kim, Sea-Yong López, Alfredo Covelo, Pablo Rydberg, Sara Reis Costa, Pedro Lage, Sandra |
dc.subject.por.fl_str_mv |
Marine mammals Phycotoxins Harmful algae blooms Bioaccumulation Marine food webs Alzheimer disease |
topic |
Marine mammals Phycotoxins Harmful algae blooms Bioaccumulation Marine food webs Alzheimer disease |
description |
The neurotoxin β-N-methylamino-L-alanine (BMAA), a non-proteinogenic amino acid produced by several species of both prokaryotic (cyanobacteria) and eukaryotic (diatoms) microorganisms, has been proposed to be associated with the development of neurodegenerative diseases. At first, BMAA appeared to be ubiquitously present worldwide in various organisms, from aquatic and terrestrial food webs. However, recent studies, using detection methods based on mass spectrometry, instead of fluorescence detection, suggest that the trophic transfer of BMAA is debatable. This study evaluated BMAA in 22 cetaceans of three different species (<i>Phocoena phocoena</i>, <i>n</i> = 8, <i>Delphinus delphis</i>, <i>n</i> = 8, and <i>Tursiops truncatus</i>, <i>n</i> = 6), found stranded in North-West Spain. BMAA analysis of the liver, kidney, or muscle tissues via sensitive liquid chromatography with tandem mass spectrometry did not reveal the presence of this compound or its isomers. The absence recorded in this study highlights the need to better understand the trophic transfer of BMAA and its anatomical distribution in marine mammals. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-28T14:30:15Z 2022-02-23 2022-03-24T14:47:07Z 2022-02-23T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/17730 |
url |
http://hdl.handle.net/10400.1/17730 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Marine Science and Engineering 10 (3): 314 (2022) 2077-1312 10.3390/jmse10030314 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133320920956928 |