Let’s review the gut microbiota in systemic lupus erythematosus

Detalhes bibliográficos
Autor(a) principal: Almada-Correia, Inês
Data de Publicação: 2022
Outros Autores: Costa Reis, Patricia, Guerreiro, Catarina Sousa, Fonseca, João Eurico
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/56317
Resumo: © The Author(s) 2022. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
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spelling Let’s review the gut microbiota in systemic lupus erythematosusSystemic lupus erythematosusGut microbiotaDysbiosis© The Author(s) 2022. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, andSystemic lupus erythematosus (SLE) is a chronic, immune-mediated disease associated with significant morbidity and mortality. New evidence suggests that diet, gut microbiota, intestinal permeability, and endotoxemia may modulate chronic inflammation and disease activity in SLE. This review focus on what is known about the gut microbiota in lupus mouse models and SLE patients and the possible mechanisms that connect the gut microbiota with SLE. It included 29 studies (12 animal studies, 15 human studies, and 2 included data on both), with variable results regarding alpha and beta-diversity and gut microbiota composition between lupus-mouse models and SLE patients. Ruminococcus ( R.) gnavus was significantly increased in lupus nephritis (LN) in one study, but this was not corroborated by others. Despite the different results, mechanistic lupus mouse model studies have shown that gut microbiota can modulate disease activity. Interestingly, pathobiont translocation in monocolonized and autoimmune-prone mice induced autoantibodies and caused mortality, which could be prevented by a vaccine targeting the pathobiont. Moreover, studies on fecal transplants and diet on different lupus mouse models showed an effect on disease activity. In SLE patients, a higher adherence to the Mediterranean diet was associated with lower disease activity, which may be explained by the connection between diet and gut microbiota. Although gut dysbiosis has been observed in SLE patients and lupus mouse models, it remains to clarify if it is a cause or a consequence of the disease or its treatments. Further studies with larger and well-characterized populations will undoubtedly contribute to deciphering the role of gut microbiota in SLE development, progression, and outcome.Open Exploration Publishing Inc.Repositório da Universidade de LisboaAlmada-Correia, InêsCosta Reis, PatriciaGuerreiro, Catarina SousaFonseca, João Eurico2023-02-14T16:56:41Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56317engExplor Med. 2022;3:540–56010.37349/emed.2022.001122692-3106info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:03:49Zoai:repositorio.ul.pt:10451/56317Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:52.449200Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Let’s review the gut microbiota in systemic lupus erythematosus
title Let’s review the gut microbiota in systemic lupus erythematosus
spellingShingle Let’s review the gut microbiota in systemic lupus erythematosus
Almada-Correia, Inês
Systemic lupus erythematosus
Gut microbiota
Dysbiosis
title_short Let’s review the gut microbiota in systemic lupus erythematosus
title_full Let’s review the gut microbiota in systemic lupus erythematosus
title_fullStr Let’s review the gut microbiota in systemic lupus erythematosus
title_full_unstemmed Let’s review the gut microbiota in systemic lupus erythematosus
title_sort Let’s review the gut microbiota in systemic lupus erythematosus
author Almada-Correia, Inês
author_facet Almada-Correia, Inês
Costa Reis, Patricia
Guerreiro, Catarina Sousa
Fonseca, João Eurico
author_role author
author2 Costa Reis, Patricia
Guerreiro, Catarina Sousa
Fonseca, João Eurico
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Almada-Correia, Inês
Costa Reis, Patricia
Guerreiro, Catarina Sousa
Fonseca, João Eurico
dc.subject.por.fl_str_mv Systemic lupus erythematosus
Gut microbiota
Dysbiosis
topic Systemic lupus erythematosus
Gut microbiota
Dysbiosis
description © The Author(s) 2022. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-02-14T16:56:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56317
url http://hdl.handle.net/10451/56317
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Explor Med. 2022;3:540–560
10.37349/emed.2022.00112
2692-3106
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Open Exploration Publishing Inc.
publisher.none.fl_str_mv Open Exploration Publishing Inc.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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