Transdermal iontophoresis—A quantitative and qualitative study

• Autor(a) principal: Ferreira, José Augusto
• Data de Publicação: 2017
• Outros Autores: Oliveira, Paula de, Pena, Gonçalo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/45494; https://doi.org/10.1016/j.camwa.2017.07.001

The use of enhancers to increase the drug molecules penetration into target tissues is a usual technique in drug delivery. In transdermal drug delivery, electric fields are often used to increase the drug transport through the skin. In this paper we study a drug delivery mechanism from a reservoir which is in contact with the skin. We assume that the drug transport in the coupled system is enhanced by a small electric field that induces a convective field. We establish energy estimates for the coupled system and we propose a semi-analytical discrete coupled model that mimics the continuous model. The qualitative behaviour of the system is illustrated.