Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/29979 |
Resumo: | To mitigate the adverse consequences of chronic hyperglycemia, patients with type 1 diabetes mellitus must provide their bodies with insulin to control their blood glucose. In most cases, insulin therapy consists of a combination of basal insulin and bolus insulin, the so-called basal-bolus insulin therapy. To determine the bolus insulin, patients must know not only the carbohydrate content of each meal but also the values of the insulin-to-carbohydrate ratio and the insulin sensitivity factor. Although important, the blood glucose complex dynamics make determining these parameters a difficult and error-prone task, usually performed by experienced diabetologists using high-quality data. Moreover, the insulin-to-carbohydrate ratio and the insulin sensitivity factor vary over the day due to several factors. Thus, daily, patients use approximate values to determine their prandial bolus. In this paper, we propose an analytic method to find the safe maximum interval for the error in the estimates of the insulin-to-carbohydrate ratio and, therefore, avoid dysglycemia. Our study suggests that slimmer patients with smaller insulin-to-carbohydrate ratios need to be more careful when estimating it. Another significant finding of our work is that in such cases, having small meals reduces the adverse effect of inaccurate insulin-to-carbohydrate ratio estimates in the postprandial blood glucose. |
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Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle managementTo mitigate the adverse consequences of chronic hyperglycemia, patients with type 1 diabetes mellitus must provide their bodies with insulin to control their blood glucose. In most cases, insulin therapy consists of a combination of basal insulin and bolus insulin, the so-called basal-bolus insulin therapy. To determine the bolus insulin, patients must know not only the carbohydrate content of each meal but also the values of the insulin-to-carbohydrate ratio and the insulin sensitivity factor. Although important, the blood glucose complex dynamics make determining these parameters a difficult and error-prone task, usually performed by experienced diabetologists using high-quality data. Moreover, the insulin-to-carbohydrate ratio and the insulin sensitivity factor vary over the day due to several factors. Thus, daily, patients use approximate values to determine their prandial bolus. In this paper, we propose an analytic method to find the safe maximum interval for the error in the estimates of the insulin-to-carbohydrate ratio and, therefore, avoid dysglycemia. Our study suggests that slimmer patients with smaller insulin-to-carbohydrate ratios need to be more careful when estimating it. Another significant finding of our work is that in such cases, having small meals reduces the adverse effect of inaccurate insulin-to-carbohydrate ratio estimates in the postprandial blood glucose.AIP Publishing2021-11-24T00:00:00Z2020-11-24T00:00:00Z2020-11-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/29979eng0094-243X10.1063/5.0026577Miranda, FranciscoAbreu, CarlosFelgueiras, Paulainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:57:54Zoai:ria.ua.pt:10773/29979Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:02:10.716018Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management |
title |
Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management |
spellingShingle |
Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management Miranda, Francisco |
title_short |
Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management |
title_full |
Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management |
title_fullStr |
Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management |
title_full_unstemmed |
Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management |
title_sort |
Assessing the impact of inaccurate insulin-to-carbohydrate ratio on the patient's glycemic targets and lifestyle management |
author |
Miranda, Francisco |
author_facet |
Miranda, Francisco Abreu, Carlos Felgueiras, Paula |
author_role |
author |
author2 |
Abreu, Carlos Felgueiras, Paula |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Miranda, Francisco Abreu, Carlos Felgueiras, Paula |
description |
To mitigate the adverse consequences of chronic hyperglycemia, patients with type 1 diabetes mellitus must provide their bodies with insulin to control their blood glucose. In most cases, insulin therapy consists of a combination of basal insulin and bolus insulin, the so-called basal-bolus insulin therapy. To determine the bolus insulin, patients must know not only the carbohydrate content of each meal but also the values of the insulin-to-carbohydrate ratio and the insulin sensitivity factor. Although important, the blood glucose complex dynamics make determining these parameters a difficult and error-prone task, usually performed by experienced diabetologists using high-quality data. Moreover, the insulin-to-carbohydrate ratio and the insulin sensitivity factor vary over the day due to several factors. Thus, daily, patients use approximate values to determine their prandial bolus. In this paper, we propose an analytic method to find the safe maximum interval for the error in the estimates of the insulin-to-carbohydrate ratio and, therefore, avoid dysglycemia. Our study suggests that slimmer patients with smaller insulin-to-carbohydrate ratios need to be more careful when estimating it. Another significant finding of our work is that in such cases, having small meals reduces the adverse effect of inaccurate insulin-to-carbohydrate ratio estimates in the postprandial blood glucose. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-24T00:00:00Z 2020-11-24 2021-11-24T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/29979 |
url |
http://hdl.handle.net/10773/29979 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0094-243X 10.1063/5.0026577 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
AIP Publishing |
publisher.none.fl_str_mv |
AIP Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137677006602240 |