Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor?
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118 |
Resumo: | Introduction: Bisphosphonates are effective in preventing osteoporotic fracture, however atypical femoral fractures with a well-defined radiological pattern have been described in association with prolonged treatment with bisphosphonates. Our objectives in this study were to characterize patients ≥ 65 years old with femoral fractures (subtrochanteric/diaphyseal) considered typical and atypical and the relationship between the occurrence of atypical fractures and bisphosphonate use.Material and Methods: We conducted a case-control study with patients admitted in our hospital with subtrochanteric or diaphyseal femur fracture in a period of five and a half years. After applying the exclusion criteria, the 92 fractures (91 patients) were classified as typical or atypical. The determination of prior bisphosphonate treatment was obtained through consultation of the individual medical history.Results: We found 11 atypical fractures (10 patients) and 81 typical fractures (81 patients). The median age of both groups was statistically different (72 years - atypical vs. 80 years - typical, p < 0.01). The reason for the use of bisphosphonates was 0.60 in atypical fractures and 0.01 in typical, and an odds ratio of 101.1 was obtained (p < 0.01).Discussion: Our results are supported and are in agreement with published studies relating to the occurrence of atypical femoral fractures associated with treatment with bisphosphonates.Conclusion: Despite the small number of cases it was possible to demonstrate a statistically significant relation between atypical femoral fractures and treatment with bisphosphonates. One should note that these atypical fractures occurred in patients significantly younger than patients with typical fractures.Keywords: Diphosphonates; Femoral Fractures; Risk Factors. |
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Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor?Fracturas Femorais Atípicas e o Tratamento com Bifosfonatos: É um Factor de Risco?Introduction: Bisphosphonates are effective in preventing osteoporotic fracture, however atypical femoral fractures with a well-defined radiological pattern have been described in association with prolonged treatment with bisphosphonates. Our objectives in this study were to characterize patients ≥ 65 years old with femoral fractures (subtrochanteric/diaphyseal) considered typical and atypical and the relationship between the occurrence of atypical fractures and bisphosphonate use.Material and Methods: We conducted a case-control study with patients admitted in our hospital with subtrochanteric or diaphyseal femur fracture in a period of five and a half years. After applying the exclusion criteria, the 92 fractures (91 patients) were classified as typical or atypical. The determination of prior bisphosphonate treatment was obtained through consultation of the individual medical history.Results: We found 11 atypical fractures (10 patients) and 81 typical fractures (81 patients). The median age of both groups was statistically different (72 years - atypical vs. 80 years - typical, p < 0.01). The reason for the use of bisphosphonates was 0.60 in atypical fractures and 0.01 in typical, and an odds ratio of 101.1 was obtained (p < 0.01).Discussion: Our results are supported and are in agreement with published studies relating to the occurrence of atypical femoral fractures associated with treatment with bisphosphonates.Conclusion: Despite the small number of cases it was possible to demonstrate a statistically significant relation between atypical femoral fractures and treatment with bisphosphonates. One should note that these atypical fractures occurred in patients significantly younger than patients with typical fractures.Keywords: Diphosphonates; Femoral Fractures; Risk Factors.Introdução: Os bifosfonatos têm eficácia comprovada na prevenção das fracturas osteoporóticas. Contudo, têm sido descritas fracturas femorais atípicas associadas à toma prolongada de bifosfonatos com um padrão radiológico bem definido. Os objectivos no nosso estudo foram caracterizar os doentes de idade ≥ 65 anos com fracturas femorais (subtrocantéricas/diafisárias) consideradas típicas e atípicas e avaliar a relação entre a ocorrência das fracturas atípicas e o uso de bifosfonatos.Material e Métodos: Realizámos um estudo caso-controlo com os doentes admitidos no nosso Hospital por fractura subtrocantérica ou diafisária do fémur, num período de cinco anos e meio. Após aplicação dos critérios de exclusão, as 92 fracturas (91 doentes) foram classificadas como atípicas ou típicas. A determinação do tratamento prévio com bifosfonatos foi obtida através do historial clínico dos doentes.Resultados: Foram encontradas 11 fracturas atípicas (10 doentes) e 81 fracturas típicas (81 doentes). A idade mediana entre os dois grupos foi estatisticamente diferente (72 anos - atípicas vs 80 anos - típicas, p < 0,01). A razão do uso de bifosfonatos foi de 0,60 nas fracturas atípicas e de 0,01 nas típicas, traduzindo um odds ratio de 101,1 (p < 0,01).Discussão: Na generalidade, os nossos resultados são apoiados e estão de acordo com os estudos publicados referentes à ocorrência de fracturas femorais atípicas associadas à toma de bifosfonatos.Conclusão: Apesar do pequeno número de casos foi possível demonstrar a relação, estatisticamente, significativa entre as fracturas femorais atípicas e a toma de bifosfonatos. De notar que estas fracturas atípicas ocorreram em doentes, significativamente, mais jovens do que os doentes com fracturas típicas.Palavras-chave: Difosfonatos; Fracturas do Fémur; Factores de Risco.Ordem dos Médicos2014-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentimage/jpegimage/jpegimage/jpegimage/jpeghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118oai:ojs.www.actamedicaportuguesa.com:article/5118Acta Médica Portuguesa; Vol. 27 No. 6 (2014): November-December; 704-709Acta Médica Portuguesa; Vol. 27 N.º 6 (2014): Novembro-Dezembro; 704-7091646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/4169https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/4245https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7154https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7155https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7156https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7157https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7158https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7195Geada, NunoMafra, InêsBarroso, RogérioFranco, Joséinfo:eu-repo/semantics/openAccess2022-12-20T11:04:13Zoai:ojs.www.actamedicaportuguesa.com:article/5118Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:02.022826Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor? Fracturas Femorais Atípicas e o Tratamento com Bifosfonatos: É um Factor de Risco? |
title |
Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor? |
spellingShingle |
Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor? Geada, Nuno |
title_short |
Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor? |
title_full |
Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor? |
title_fullStr |
Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor? |
title_full_unstemmed |
Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor? |
title_sort |
Atypical Femoral Fractures and Bisphosphonates Treatment: Is it a Risk Factor? |
author |
Geada, Nuno |
author_facet |
Geada, Nuno Mafra, Inês Barroso, Rogério Franco, José |
author_role |
author |
author2 |
Mafra, Inês Barroso, Rogério Franco, José |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Geada, Nuno Mafra, Inês Barroso, Rogério Franco, José |
description |
Introduction: Bisphosphonates are effective in preventing osteoporotic fracture, however atypical femoral fractures with a well-defined radiological pattern have been described in association with prolonged treatment with bisphosphonates. Our objectives in this study were to characterize patients ≥ 65 years old with femoral fractures (subtrochanteric/diaphyseal) considered typical and atypical and the relationship between the occurrence of atypical fractures and bisphosphonate use.Material and Methods: We conducted a case-control study with patients admitted in our hospital with subtrochanteric or diaphyseal femur fracture in a period of five and a half years. After applying the exclusion criteria, the 92 fractures (91 patients) were classified as typical or atypical. The determination of prior bisphosphonate treatment was obtained through consultation of the individual medical history.Results: We found 11 atypical fractures (10 patients) and 81 typical fractures (81 patients). The median age of both groups was statistically different (72 years - atypical vs. 80 years - typical, p < 0.01). The reason for the use of bisphosphonates was 0.60 in atypical fractures and 0.01 in typical, and an odds ratio of 101.1 was obtained (p < 0.01).Discussion: Our results are supported and are in agreement with published studies relating to the occurrence of atypical femoral fractures associated with treatment with bisphosphonates.Conclusion: Despite the small number of cases it was possible to demonstrate a statistically significant relation between atypical femoral fractures and treatment with bisphosphonates. One should note that these atypical fractures occurred in patients significantly younger than patients with typical fractures.Keywords: Diphosphonates; Femoral Fractures; Risk Factors. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-30 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118 oai:ojs.www.actamedicaportuguesa.com:article/5118 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118 |
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oai:ojs.www.actamedicaportuguesa.com:article/5118 |
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por eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/4169 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/4245 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7154 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7155 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7156 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7157 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7158 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5118/7195 |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 27 No. 6 (2014): November-December; 704-709 Acta Médica Portuguesa; Vol. 27 N.º 6 (2014): Novembro-Dezembro; 704-709 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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