Dithiothreitol revisited in red cells : a new head for an old hat

Detalhes bibliográficos
Autor(a) principal: Almeida, J. P. Lopes de
Data de Publicação: 2010
Outros Autores: Saldanha, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/6351
Resumo: © 2010 – IOS Press and the authors. All rights reserved
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spelling Dithiothreitol revisited in red cells : a new head for an old hatDithiothreitolErythrocyteRedox statusThiols© 2010 – IOS Press and the authors. All rights reservedIn the present article the authors make an approach over the applications of dithiothreitol (DTT) in its different clinicallaboratory, potential and up-to-date sources. Dithiothreitol is a chemical reagent with a wide actuation spectrum not only from a laboratorial view but also from a therapeutic standpoint, more clinical and practical. DTT (i) is frequently used in a variety of experiences that involve proteins or peptides, protecting sulfhydryl groups from oxidation and reducing disulfide bonds between cysteines; (ii) is also used in the study of disulfide exchange reactions of protein disulfides; (iii) is able to keep glutathione in the reduced state; (iv) acts as an “antidote” enabling the activity of detoxification systems; (v) participates in cellular mechanisms such as vesiculation, cell morphology, signal transduction pathways (hormone-‘like’ role), etc.; (vi) can be used in the treatment approach of diseases like cystinosis or medical conditions resulting from ion or metal toxicity. In erythrocytes, there’s literature pointing that DTT may trigger changes on the normal discoid shape following metabolic depletion, and additionally modulate the exovesiculation kinetics as demonstrated by us. The present article dissects in detail recent findings in our Unit concerning the DTT influence on human erythrocytes.IOS PressRepositório da Universidade de LisboaAlmeida, J. P. Lopes deSaldanha, C.2012-05-21T15:45:14Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/6351engClinical Hemorheology and Microcirculation 46 (2010) 51–561386-0291info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:48:50Zoai:repositorio.ul.pt:10451/6351Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:31:30.811766Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dithiothreitol revisited in red cells : a new head for an old hat
title Dithiothreitol revisited in red cells : a new head for an old hat
spellingShingle Dithiothreitol revisited in red cells : a new head for an old hat
Almeida, J. P. Lopes de
Dithiothreitol
Erythrocyte
Redox status
Thiols
title_short Dithiothreitol revisited in red cells : a new head for an old hat
title_full Dithiothreitol revisited in red cells : a new head for an old hat
title_fullStr Dithiothreitol revisited in red cells : a new head for an old hat
title_full_unstemmed Dithiothreitol revisited in red cells : a new head for an old hat
title_sort Dithiothreitol revisited in red cells : a new head for an old hat
author Almeida, J. P. Lopes de
author_facet Almeida, J. P. Lopes de
Saldanha, C.
author_role author
author2 Saldanha, C.
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Almeida, J. P. Lopes de
Saldanha, C.
dc.subject.por.fl_str_mv Dithiothreitol
Erythrocyte
Redox status
Thiols
topic Dithiothreitol
Erythrocyte
Redox status
Thiols
description © 2010 – IOS Press and the authors. All rights reserved
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
2012-05-21T15:45:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/6351
url http://hdl.handle.net/10451/6351
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Hemorheology and Microcirculation 46 (2010) 51–56
1386-0291
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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