Multivariate analysis applied to clinical analysis data

Detalhes bibliográficos
Autor(a) principal: Tavares, Nuno Filipe Ramalho da Cunha
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/12288
Resumo: Dissertação para obtenção do Grau de Mestre em Engenharia e Gestão Industrial
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spelling Multivariate analysis applied to clinical analysis dataCluster analysisSpearman correlationFolateVitamin B12BiomarkersKruskal-WallisDissertação para obtenção do Grau de Mestre em Engenharia e Gestão IndustrialFolate, vitamin B12, iron and hemoglobin are essential for metabolic functions in the body. The deficiency of these can be the cause of several known pathologies and, untreated, can be responsible for severe morbidity and even death. The objective of this study is to characterize a population, residing in the metropolitan area of Lisbon and Setubal, concerning serum levels of folate, vitamin B12, iron and hemoglobin, as well as finding evidence of correlations between these parameters and illnesses, mainly cardiovascular, gastrointestinal, neurological and anemia. Clinical analysis data was collected and submitted to multivariate analysis. First the data was screened with Spearman correlation and Kruskal-Wallis analysis of variance to study correlations and variability between groups. To characterize the population, we used cluster analysis with Ward’s linkage method. Finally a sensitivity analysis was performed to strengthen the results. A positive correlation between iron with, ferritin and transferrin, and with hemoglobin was observed with the Spearman correlation. Kruskal-Wallis analysis of variance test showed significant differences between these biomarkers in persons aged 0 to 29, 30 to 59 and over 60 years old. Cluster analysis proved to be a useful tool when characterizing a population based on its biomarkers, showing evidence of low folate levels for the population in general, and hemoglobin levels below the reference values. Iron and vitamin B12 were within the reference range for most of the population. Low levels of the parameters were registered mainly in patients with cardiovascular, gastrointestinal, and neurological diseases and anemia.Faculdade de Ciências e TecnologiaMatos, AnaLeal, RogérioRUNTavares, Nuno Filipe Ramalho da Cunha2014-06-27T16:04:29Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/12288enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T03:47:13Zoai:run.unl.pt:10362/12288Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:20:51.001407Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Multivariate analysis applied to clinical analysis data
title Multivariate analysis applied to clinical analysis data
spellingShingle Multivariate analysis applied to clinical analysis data
Tavares, Nuno Filipe Ramalho da Cunha
Cluster analysis
Spearman correlation
Folate
Vitamin B12
Biomarkers
Kruskal-Wallis
title_short Multivariate analysis applied to clinical analysis data
title_full Multivariate analysis applied to clinical analysis data
title_fullStr Multivariate analysis applied to clinical analysis data
title_full_unstemmed Multivariate analysis applied to clinical analysis data
title_sort Multivariate analysis applied to clinical analysis data
author Tavares, Nuno Filipe Ramalho da Cunha
author_facet Tavares, Nuno Filipe Ramalho da Cunha
author_role author
dc.contributor.none.fl_str_mv Matos, Ana
Leal, Rogério
RUN
dc.contributor.author.fl_str_mv Tavares, Nuno Filipe Ramalho da Cunha
dc.subject.por.fl_str_mv Cluster analysis
Spearman correlation
Folate
Vitamin B12
Biomarkers
Kruskal-Wallis
topic Cluster analysis
Spearman correlation
Folate
Vitamin B12
Biomarkers
Kruskal-Wallis
description Dissertação para obtenção do Grau de Mestre em Engenharia e Gestão Industrial
publishDate 2014
dc.date.none.fl_str_mv 2014-06-27T16:04:29Z
2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/12288
url http://hdl.handle.net/10362/12288
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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