Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/13730 |
Resumo: | Portugal is among the European Union countries most devastated by forest fires each year. In the last three decades, more than 3.8 million hectares of forest were burned. Wildland firefighters are exposed to a variety of hazards, including many toxic combustion products that may lead to deleterious health effects. Epidemiological studies showed a positive association between firefighting and several chronic diseases, including cancer. Results from biomonitoring studies in firefighters, particularly concerning genotoxicity evaluation, constitute a valuable tool for investigating important occupational hazards. Thus, the aim of this study was to assess genotoxicity in a group of wildland firefighters using the comet assay for DNA damage and oxidative stress. Both parameters were increased in firefighters compared to controls, but significance was only found for basal DNA damage. No significant influence was found regarding major confounding variables on the genotoxic endpoints studied, with the exception of age. Data obtained provide preliminary information on human health effects of wildland firefighting exposure at genetic and molecular levels. These findings may also provide new important data to serve as public awareness to the potential adverse health risks involving wildland firefighting. Implementation of security and hygiene measures in this sector as well as good practices campaigns may be crucial to decrease risk. |
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Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluationAdultCase-Control StudiesComet AssayDNA DamageFemaleFiresForestsHumansMaleOccupational ExposureOxidative StressPortugalSmokeFirefightersPortugal is among the European Union countries most devastated by forest fires each year. In the last three decades, more than 3.8 million hectares of forest were burned. Wildland firefighters are exposed to a variety of hazards, including many toxic combustion products that may lead to deleterious health effects. Epidemiological studies showed a positive association between firefighting and several chronic diseases, including cancer. Results from biomonitoring studies in firefighters, particularly concerning genotoxicity evaluation, constitute a valuable tool for investigating important occupational hazards. Thus, the aim of this study was to assess genotoxicity in a group of wildland firefighters using the comet assay for DNA damage and oxidative stress. Both parameters were increased in firefighters compared to controls, but significance was only found for basal DNA damage. No significant influence was found regarding major confounding variables on the genotoxic endpoints studied, with the exception of age. Data obtained provide preliminary information on human health effects of wildland firefighting exposure at genetic and molecular levels. These findings may also provide new important data to serve as public awareness to the potential adverse health risks involving wildland firefighting. Implementation of security and hygiene measures in this sector as well as good practices campaigns may be crucial to decrease risk.Taylor & FrancisRepositório Científico do Instituto Politécnico do PortoAbreu, AnaCosta, CarlaPinho e Silva, SusanaMorais, SimonePereira, Maria do CarmoFernandes, AdíliaMoraes de Andrade, VanessaTeixeira, João PauloCosta, Solange2019-05-16T14:41:19Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/13730eng1528-739410.1080/15287394.2017.1286896info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:55:25Zoai:recipp.ipp.pt:10400.22/13730Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:33:30.205838Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation |
title |
Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation |
spellingShingle |
Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation Abreu, Ana Adult Case-Control Studies Comet Assay DNA Damage Female Fires Forests Humans Male Occupational Exposure Oxidative Stress Portugal Smoke Firefighters |
title_short |
Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation |
title_full |
Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation |
title_fullStr |
Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation |
title_full_unstemmed |
Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation |
title_sort |
Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation |
author |
Abreu, Ana |
author_facet |
Abreu, Ana Costa, Carla Pinho e Silva, Susana Morais, Simone Pereira, Maria do Carmo Fernandes, Adília Moraes de Andrade, Vanessa Teixeira, João Paulo Costa, Solange |
author_role |
author |
author2 |
Costa, Carla Pinho e Silva, Susana Morais, Simone Pereira, Maria do Carmo Fernandes, Adília Moraes de Andrade, Vanessa Teixeira, João Paulo Costa, Solange |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Abreu, Ana Costa, Carla Pinho e Silva, Susana Morais, Simone Pereira, Maria do Carmo Fernandes, Adília Moraes de Andrade, Vanessa Teixeira, João Paulo Costa, Solange |
dc.subject.por.fl_str_mv |
Adult Case-Control Studies Comet Assay DNA Damage Female Fires Forests Humans Male Occupational Exposure Oxidative Stress Portugal Smoke Firefighters |
topic |
Adult Case-Control Studies Comet Assay DNA Damage Female Fires Forests Humans Male Occupational Exposure Oxidative Stress Portugal Smoke Firefighters |
description |
Portugal is among the European Union countries most devastated by forest fires each year. In the last three decades, more than 3.8 million hectares of forest were burned. Wildland firefighters are exposed to a variety of hazards, including many toxic combustion products that may lead to deleterious health effects. Epidemiological studies showed a positive association between firefighting and several chronic diseases, including cancer. Results from biomonitoring studies in firefighters, particularly concerning genotoxicity evaluation, constitute a valuable tool for investigating important occupational hazards. Thus, the aim of this study was to assess genotoxicity in a group of wildland firefighters using the comet assay for DNA damage and oxidative stress. Both parameters were increased in firefighters compared to controls, but significance was only found for basal DNA damage. No significant influence was found regarding major confounding variables on the genotoxic endpoints studied, with the exception of age. Data obtained provide preliminary information on human health effects of wildland firefighting exposure at genetic and molecular levels. These findings may also provide new important data to serve as public awareness to the potential adverse health risks involving wildland firefighting. Implementation of security and hygiene measures in this sector as well as good practices campaigns may be crucial to decrease risk. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2019-05-16T14:41:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/13730 |
url |
http://hdl.handle.net/10400.22/13730 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1528-7394 10.1080/15287394.2017.1286896 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131427692871680 |