Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.77.2.1074 |
Resumo: | Introduction: Topical immunotherapy with diphenylcyclopropenone is a treatment option for patients with refractory or extensive alopecia areata. The aim of this study was to evaluate the clinical efficacy and tolerability of diphenylcyclopropenone therapy, in patients with alopecia areata, and identify possible prognostic factors that predict response to treatment. Methods: We conducted a retrospective study that included all patients diagnosed with alopecia areata and treated with diphenylcyclopropenone at our Department. Results: Twenty one patients were included for analysis (15 females and 6 males). Overall, nine patients (42.9%) had some hair regrowth with diphenylcyclopropenone therapy. Of these, five (55.6%) achieved pigmented terminal hair regrowth but with persistent patches of alopecia. Only one patient achieved > 90% of hair regrowth. Older age at onset, broader extent of alopecia at baseline and presence of nail dystrophy were all negative prognostic factors (p < 0.05). Atopy and thyroid dysfunction were not statistically significant as predictors of poor treatment outcome. Adverse effects were documented in 15 patients, most of them were mild and did not lead to treatment interruption. Conclusion: Diphenylcyclopropenone therapy is a viable treatment option in patients with extensive alopecia areata, although the response is partial in the majority of the cases. Limitations of this study include its retrospective nature and the limited number of patients. |
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Topical Immunomodulation with Diphenlycyclopropenone for Alopecia AreataImunomodelação Tópica com Difenilciclopropenona para a Alopécia AreataAlopecia Areata/therapyCyclopropanesDermatologic AgentsImmunotherapyAlopécia Areata/tratamentoCiclopropanosFármacos DermatológicosImunoterapiaIntroduction: Topical immunotherapy with diphenylcyclopropenone is a treatment option for patients with refractory or extensive alopecia areata. The aim of this study was to evaluate the clinical efficacy and tolerability of diphenylcyclopropenone therapy, in patients with alopecia areata, and identify possible prognostic factors that predict response to treatment. Methods: We conducted a retrospective study that included all patients diagnosed with alopecia areata and treated with diphenylcyclopropenone at our Department. Results: Twenty one patients were included for analysis (15 females and 6 males). Overall, nine patients (42.9%) had some hair regrowth with diphenylcyclopropenone therapy. Of these, five (55.6%) achieved pigmented terminal hair regrowth but with persistent patches of alopecia. Only one patient achieved > 90% of hair regrowth. Older age at onset, broader extent of alopecia at baseline and presence of nail dystrophy were all negative prognostic factors (p < 0.05). Atopy and thyroid dysfunction were not statistically significant as predictors of poor treatment outcome. Adverse effects were documented in 15 patients, most of them were mild and did not lead to treatment interruption. Conclusion: Diphenylcyclopropenone therapy is a viable treatment option in patients with extensive alopecia areata, although the response is partial in the majority of the cases. Limitations of this study include its retrospective nature and the limited number of patients.Introdução: A imunoterapia tópica com difenilciclopropenona é uma opção terapêutica em casos de alopécia areata extensa ou refratária. Este estudo teve como objetivos avaliar a eficácia clínica e tolerabilidade da terapia com difenilciclopropenona, em doentes com alopécia areata, e identificar possíveis fatores prognósticos da resposta ao tratamento. Métodos: Realizámos um estudo retrospetivo que incluiu todos os doentes diagnosticados com alopécia areata e tratados com difenilciclopropenona no Serviço de Dermatologia do Hospital Santo António dos Capuchos, Centro Hospitalar e Universitário de Lisboa Central. Resultados: Foram incluídos vinte e um doentes (15 mulheres e 6 homens). No geral, nove pacientes (42,9%) tiveram algum crescimento de cabelo com a terapia DPCP. Destes, cinco (55,6%) tiveram crescimento do pêlo terminal pigmentado, mas com áreas de alopécia persistentes. Apenas um doente atingiu mais de 90% de reponte capilar. A idade mais avançada e a maior extensão da doença à apresentação, assim como a presença de distrofia ungueal foram fatores estatisticamente significativos de mau prognóstico (p < 0,05). Atopia e disfunção tiroideia não foram estatisticamente significativos como preditores de pior resultado terapêutico com difenilciclopropenona. Efeitos adversos foram documentados em 15 doentes, sendo na maioria de ligeira gravidade não implicando a interrupção do tratamento. Conclusão: O tratamento com difenilciclopropenona é uma opção de tratamento viável em pacientes com alopécia areata extensa, embora a resposta seja parcial na maioria dos casos. As limitações deste estudo incluem a sua natureza retrospetiva e a amostra reduzida de doentes.Sociedade Portuguesa de Dermatologia e Venereologia2019-07-12T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.77.2.1074oai:ojs.revista.spdv.com.pt:article/1074Journal of the Portuguese Society of Dermatology and Venereology; Vol 77 No 2 (2019): April / June; 139-142Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 77 n. 2 (2019): Abril / Junho; 139-1422182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spdv.com.pt/index.php/spdv/article/view/1074https://doi.org/10.29021/spdv.77.2.1074https://revista.spdv.com.pt/index.php/spdv/article/view/1074/776Borges, Ana SofiaBrasileiro, AnaRamos Pinheiro, RitaLencastre, Andréinfo:eu-repo/semantics/openAccess2022-10-06T12:35:11Zoai:ojs.revista.spdv.com.pt:article/1074Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:09.981024Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata Imunomodelação Tópica com Difenilciclopropenona para a Alopécia Areata |
title |
Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata |
spellingShingle |
Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata Borges, Ana Sofia Alopecia Areata/therapy Cyclopropanes Dermatologic Agents Immunotherapy Alopécia Areata/tratamento Ciclopropanos Fármacos Dermatológicos Imunoterapia |
title_short |
Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata |
title_full |
Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata |
title_fullStr |
Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata |
title_full_unstemmed |
Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata |
title_sort |
Topical Immunomodulation with Diphenlycyclopropenone for Alopecia Areata |
author |
Borges, Ana Sofia |
author_facet |
Borges, Ana Sofia Brasileiro, Ana Ramos Pinheiro, Rita Lencastre, André |
author_role |
author |
author2 |
Brasileiro, Ana Ramos Pinheiro, Rita Lencastre, André |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Borges, Ana Sofia Brasileiro, Ana Ramos Pinheiro, Rita Lencastre, André |
dc.subject.por.fl_str_mv |
Alopecia Areata/therapy Cyclopropanes Dermatologic Agents Immunotherapy Alopécia Areata/tratamento Ciclopropanos Fármacos Dermatológicos Imunoterapia |
topic |
Alopecia Areata/therapy Cyclopropanes Dermatologic Agents Immunotherapy Alopécia Areata/tratamento Ciclopropanos Fármacos Dermatológicos Imunoterapia |
description |
Introduction: Topical immunotherapy with diphenylcyclopropenone is a treatment option for patients with refractory or extensive alopecia areata. The aim of this study was to evaluate the clinical efficacy and tolerability of diphenylcyclopropenone therapy, in patients with alopecia areata, and identify possible prognostic factors that predict response to treatment. Methods: We conducted a retrospective study that included all patients diagnosed with alopecia areata and treated with diphenylcyclopropenone at our Department. Results: Twenty one patients were included for analysis (15 females and 6 males). Overall, nine patients (42.9%) had some hair regrowth with diphenylcyclopropenone therapy. Of these, five (55.6%) achieved pigmented terminal hair regrowth but with persistent patches of alopecia. Only one patient achieved > 90% of hair regrowth. Older age at onset, broader extent of alopecia at baseline and presence of nail dystrophy were all negative prognostic factors (p < 0.05). Atopy and thyroid dysfunction were not statistically significant as predictors of poor treatment outcome. Adverse effects were documented in 15 patients, most of them were mild and did not lead to treatment interruption. Conclusion: Diphenylcyclopropenone therapy is a viable treatment option in patients with extensive alopecia areata, although the response is partial in the majority of the cases. Limitations of this study include its retrospective nature and the limited number of patients. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07-12T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.77.2.1074 oai:ojs.revista.spdv.com.pt:article/1074 |
url |
https://doi.org/10.29021/spdv.77.2.1074 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/1074 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/1074 https://doi.org/10.29021/spdv.77.2.1074 https://revista.spdv.com.pt/index.php/spdv/article/view/1074/776 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 77 No 2 (2019): April / June; 139-142 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 77 n. 2 (2019): Abril / Junho; 139-142 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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