Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer

• Autor(a) principal: Tereso, Andreia
• Data de Publicação: 2019
• Outros Autores: Carreto, Luís, Baptista, Manuela, Almeida, Maria Amélia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9456
• topic: Carcinoma; Non-Small-Cell Lung/drug therapy; Crizotinib; Lung Diseases; Interstitial/chemically induced; Interstitial/diagnosis; Tomography; X-Ray Computed; Carcinoma Pulmonar de Células não Pequenas/tratamento; Crizotinib; Doenças Pulmonares Intersticiais/diagnóstico; Doenças Pulmonares Intersticiais/induzidas quimicamente; Tomografia Computorizada

The treatment of advanced non-small-cell lung cancer shifted with the development of molecular-targeted therapies, like the tyrosine kinase inhibitors. One example of tyrosine kinase inhibitors is crizotinib, an anaplastic lymphoma tyrosine kinase inhibitor, which targets an echinoderm microtubule-associated protein-like-4-anaplastic lymphoma kinase gene fusion. This mutation is found in only 2% to 7% of non-small-cell lung cancer cases. Although these new therapies have shown promising results, the occurrence of interstitial lung disease as a side effect could be problematic. As the diagnosis of drug-related-interstitial lung disease is difficult to make, computed tomography is an important diagnostic tool. The recognition of computed tomography manifestations of tyrosine kinase inhibitors -induced interstitial lung disease is the key for an early recognition and management of this pulmonary toxicity. We aim to raise awareness of tyrosine kinase inhibitors-induced interstitial lung disease, by reporting the first case of a Portuguese patient treated with crizotinib for non-small-cell lung cancer who developed drug-induced interstitial lung disease.