Lack of detectable allergenicity of transgenic maize and soya samples
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/114 |
Resumo: | Background: The safety issues regarding foods derived from genetically modified (GM) plants are central to their acceptance into the food supply. The potential allergenicity of proteins newly introduced in GM foods is a major safety concern. Objective: We sought to monitor, in potentially sensitive human populations, the allergenicity effects of 5 GM materials obtained from sources with no allergenic potential and already under commercialization in the European Union. Methods: We have performed skin prick tests with protein extracts prepared from transgenic maize (MON810, Bt11, T25, Bt176) and soya (Roundup Ready) samples and from nontransgenic control samples in 2 sensitive groups: children with food and inhalant allergy and individuals with asthmarhinitis. We have also tested IgE immunoblot reactivity of sera from patients with food allergy to soya (Roundup Ready) and maize (MON810, Bt11, Bt176) samples, as well as to the pure transgenic proteins (CryIA[b] and CP4 5-enolpyruvylshikimate- 3-phosphate synthase). Results: None of the individuals undergoing tests reacted differentially to the transgenic and nontransgenic samples under study. None of the volunteers tested presented detectable IgE antibodies against pure transgenic proteins. Conclusion: The transgenic products under testing seem to be safe in terms of allergenic potential. We propose postmarket testing as an important screening strategy for putative allergic sensitization to proteins introduced in transgenic plants. |
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Lack of detectable allergenicity of transgenic maize and soya samplesTransgenic foodAllergenicityImmune responsePublic healthFood safetyRecombinant DNA technologySegurança AlimentarBackground: The safety issues regarding foods derived from genetically modified (GM) plants are central to their acceptance into the food supply. The potential allergenicity of proteins newly introduced in GM foods is a major safety concern. Objective: We sought to monitor, in potentially sensitive human populations, the allergenicity effects of 5 GM materials obtained from sources with no allergenic potential and already under commercialization in the European Union. Methods: We have performed skin prick tests with protein extracts prepared from transgenic maize (MON810, Bt11, T25, Bt176) and soya (Roundup Ready) samples and from nontransgenic control samples in 2 sensitive groups: children with food and inhalant allergy and individuals with asthmarhinitis. We have also tested IgE immunoblot reactivity of sera from patients with food allergy to soya (Roundup Ready) and maize (MON810, Bt11, Bt176) samples, as well as to the pure transgenic proteins (CryIA[b] and CP4 5-enolpyruvylshikimate- 3-phosphate synthase). Results: None of the individuals undergoing tests reacted differentially to the transgenic and nontransgenic samples under study. None of the volunteers tested presented detectable IgE antibodies against pure transgenic proteins. Conclusion: The transgenic products under testing seem to be safe in terms of allergenic potential. We propose postmarket testing as an important screening strategy for putative allergic sensitization to proteins introduced in transgenic plants.Supported by Fundação Calouste Gulbenkian, research project SDH.SP.I.01.11 and by Comissão de Fomento da Investigação em Cuidados de Saúde, research project no. 186/01ElsevierRepositório Científico do Instituto Nacional de SaúdeBatista, RitaNunes, BaltazarCarmo, ManuelaCardoso, CarlosHelena, São JoséAlmeida, António Bugalho deManique, AldaBento, LeonorRicardo, Cândido PintoOliveira, Maria Margarida2011-09-01T16:46:49Z2005-082005-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/114engJ Allergy Clin Immunol. 2005 Aug;116(2):403-100091-6749doi:10.1016/j.jaci.2005.04.014info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:38:01Zoai:repositorio.insa.pt:10400.18/114Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:35:19.502975Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lack of detectable allergenicity of transgenic maize and soya samples |
title |
Lack of detectable allergenicity of transgenic maize and soya samples |
spellingShingle |
Lack of detectable allergenicity of transgenic maize and soya samples Batista, Rita Transgenic food Allergenicity Immune response Public health Food safety Recombinant DNA technology Segurança Alimentar |
title_short |
Lack of detectable allergenicity of transgenic maize and soya samples |
title_full |
Lack of detectable allergenicity of transgenic maize and soya samples |
title_fullStr |
Lack of detectable allergenicity of transgenic maize and soya samples |
title_full_unstemmed |
Lack of detectable allergenicity of transgenic maize and soya samples |
title_sort |
Lack of detectable allergenicity of transgenic maize and soya samples |
author |
Batista, Rita |
author_facet |
Batista, Rita Nunes, Baltazar Carmo, Manuela Cardoso, Carlos Helena, São José Almeida, António Bugalho de Manique, Alda Bento, Leonor Ricardo, Cândido Pinto Oliveira, Maria Margarida |
author_role |
author |
author2 |
Nunes, Baltazar Carmo, Manuela Cardoso, Carlos Helena, São José Almeida, António Bugalho de Manique, Alda Bento, Leonor Ricardo, Cândido Pinto Oliveira, Maria Margarida |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Batista, Rita Nunes, Baltazar Carmo, Manuela Cardoso, Carlos Helena, São José Almeida, António Bugalho de Manique, Alda Bento, Leonor Ricardo, Cândido Pinto Oliveira, Maria Margarida |
dc.subject.por.fl_str_mv |
Transgenic food Allergenicity Immune response Public health Food safety Recombinant DNA technology Segurança Alimentar |
topic |
Transgenic food Allergenicity Immune response Public health Food safety Recombinant DNA technology Segurança Alimentar |
description |
Background: The safety issues regarding foods derived from genetically modified (GM) plants are central to their acceptance into the food supply. The potential allergenicity of proteins newly introduced in GM foods is a major safety concern. Objective: We sought to monitor, in potentially sensitive human populations, the allergenicity effects of 5 GM materials obtained from sources with no allergenic potential and already under commercialization in the European Union. Methods: We have performed skin prick tests with protein extracts prepared from transgenic maize (MON810, Bt11, T25, Bt176) and soya (Roundup Ready) samples and from nontransgenic control samples in 2 sensitive groups: children with food and inhalant allergy and individuals with asthmarhinitis. We have also tested IgE immunoblot reactivity of sera from patients with food allergy to soya (Roundup Ready) and maize (MON810, Bt11, Bt176) samples, as well as to the pure transgenic proteins (CryIA[b] and CP4 5-enolpyruvylshikimate- 3-phosphate synthase). Results: None of the individuals undergoing tests reacted differentially to the transgenic and nontransgenic samples under study. None of the volunteers tested presented detectable IgE antibodies against pure transgenic proteins. Conclusion: The transgenic products under testing seem to be safe in terms of allergenic potential. We propose postmarket testing as an important screening strategy for putative allergic sensitization to proteins introduced in transgenic plants. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-08 2005-08-01T00:00:00Z 2011-09-01T16:46:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/114 |
url |
http://hdl.handle.net/10400.18/114 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Allergy Clin Immunol. 2005 Aug;116(2):403-10 0091-6749 doi:10.1016/j.jaci.2005.04.014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132078868004864 |