Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control

Detalhes bibliográficos
Autor(a) principal: Jorge, Helena
Data de Publicação: 2022
Outros Autores: Duarte, Isabel C., Paiva, Sandra, Relvas, Ana Paula, Castelo-Branco, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/99578
https://doi.org/10.4093/dmj.2021.0307
Resumo: Published online: March 22, 2022
id RCAP_fa0cdf8feb71e7fb6169106992173390
oai_identifier_str oai:estudogeral.uc.pt:10316/99578
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic ControlDecision makingDiabetes mellitus type 1Glycated hemoglobin AImpulsive behaviorRisk factorsTreatment adherence and compliancePublished online: March 22, 2022Background: Risky health decisions and impulse control profiles may impact on metabolic control in type 1 diabetes mellitus (T1DM). We hypothesize that the neural correlates of cognitive impulsivity and decision-making in T1DM relate to metabolic control trajectories. Methods: We combined functional magnetic resonance imaging (fMRI), measures of metabolic trajectories (glycosylated hemoglobin [HbA1c] over multiple time points) and behavioral assessment using a cognitive impulsivity paradigm, the Balloon Analogue Risk Task (BART), in 50 participants (25 T1DM and 25 controls). Results: Behavioral results showed that T1DM participants followed a rigid conservative risk strategy along the iterative game. Imaging group comparisons showed that patients showed larger activation of reward related, limbic regions (nucleus accumbens, amygdala) and insula (interoceptive saliency network) in initial game stages. Upon game completion differences emerged in relation to error monitoring (anterior cingulate cortex [ACC]) and inhibitory control (inferior frontal gyrus). Importantly, activity in the saliency network (ACC and insula), which monitors interoceptive states, was related with metabolic trajectories, which was also found for limbic/reward networks. Parietal and posterior cingulate regions activated both in controls and patients with adaptive decision-making, and positively associated with metabolic trajectories. Conclusion: We found triple converging evidence when comparing metabolic trajectories, patients versus controls or risk averse (non-learners) versus patients who learned by trial and error. Dopaminergic reward and saliency (interoceptive and error monitoring) circuits show a tight link with impaired metabolic trajectories and cognitive impulsivity in T1DM. Activity in parietal and posterior cingulate are associated with adaptive trajectories. This link between reward-saliency-inhibition circuits suggests novel strategies for patient management.Korean Diabetes Association2022-03-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/99578http://hdl.handle.net/10316/99578https://doi.org/10.4093/dmj.2021.0307eng2233-60872233-6079https://doi.org/10.4093/dmj.2021.0307Jorge, HelenaDuarte, Isabel C.Paiva, SandraRelvas, Ana PaulaCastelo-Branco, Miguelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T09:42:05Zoai:estudogeral.uc.pt:10316/99578Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:17:09.527264Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control
title Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control
spellingShingle Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control
Jorge, Helena
Decision making
Diabetes mellitus type 1
Glycated hemoglobin A
Impulsive behavior
Risk factors
Treatment adherence and compliance
title_short Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control
title_full Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control
title_fullStr Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control
title_full_unstemmed Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control
title_sort Abnormal Responses in Cognitive Impulsivity Circuits Are Associated with Glycosylated Hemoglobin Trajectories in Type 1 Diabetes Mellitus and Impaired Metabolic Control
author Jorge, Helena
author_facet Jorge, Helena
Duarte, Isabel C.
Paiva, Sandra
Relvas, Ana Paula
Castelo-Branco, Miguel
author_role author
author2 Duarte, Isabel C.
Paiva, Sandra
Relvas, Ana Paula
Castelo-Branco, Miguel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Jorge, Helena
Duarte, Isabel C.
Paiva, Sandra
Relvas, Ana Paula
Castelo-Branco, Miguel
dc.subject.por.fl_str_mv Decision making
Diabetes mellitus type 1
Glycated hemoglobin A
Impulsive behavior
Risk factors
Treatment adherence and compliance
topic Decision making
Diabetes mellitus type 1
Glycated hemoglobin A
Impulsive behavior
Risk factors
Treatment adherence and compliance
description Published online: March 22, 2022
publishDate 2022
dc.date.none.fl_str_mv 2022-03-22
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/99578
http://hdl.handle.net/10316/99578
https://doi.org/10.4093/dmj.2021.0307
url http://hdl.handle.net/10316/99578
https://doi.org/10.4093/dmj.2021.0307
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2233-6087
2233-6079
https://doi.org/10.4093/dmj.2021.0307
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Korean Diabetes Association
publisher.none.fl_str_mv Korean Diabetes Association
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134066848563200

Registros relacionados