Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/119035 |
Resumo: | Signet-ring cells are relatively common in breast cancers but are frequently overlooked. Although previously defined as a subtype of mucin producing carcinomas, breast carcinomas with signet-ring cell (SRC) differentiation nowadays are not considered a distinct entity.The objective of the present study was to characterize the morphological features and mucin expression profile of breast carcinomas with SRC differentiation. All breast carcinomas diagnosed at Centro Hospitalar S. Joao between 1996 and 2006 in which the pathology report mentioned the presence of SRCs (n= 11) and four mucinous carcinomas were included in the study. The frequency of SRCs and immunohistochemistry expression of MUC1/MUC2/MUC5AC/MUC6 were evaluated.We confirmed that SRC differentiation can occur in different histological types, including ductal, lobular, mucinous and metaplastic carcinomas. The proportion of SRCs was highly variable (range: 8-70%). Tumors encompassed SRCs of intracytoplasmic lumina and goblet-cell type. A higher percentage of SRCs was associated with lymphovascular invasion (p= 0.047). All tumors expressed cytoplasmic and membranous MUC1. Secretory mucins were more frequent in mucinous carcinomas and in carcinomas with extensive SRC differentiation.We conclude that besides the usefulness of mucin immunodetection for the differential diagnosis of carcinomas with SRC differentiation of breast origin, it is important to report SRC differentiation regardless of histological type because of its intrinsic prognostic value. |
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Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiationAdultAgedAged, 80 and overBiomarkers, Tumor/metabolismBreast Neoplasms/metabolismBreast Neoplasms/pathologyCarcinoma, Signet Ring Cell/metabolismCell Differentiation/physiologyCell ShapeFemaleHumansImmunohistochemistry/methodsMembrane Glycoproteins/metabolismMiddle AgedMucins/metabolismStomach Neoplasms/metabolismStomach Neoplasms/pathologySignet-ring cells are relatively common in breast cancers but are frequently overlooked. Although previously defined as a subtype of mucin producing carcinomas, breast carcinomas with signet-ring cell (SRC) differentiation nowadays are not considered a distinct entity.The objective of the present study was to characterize the morphological features and mucin expression profile of breast carcinomas with SRC differentiation. All breast carcinomas diagnosed at Centro Hospitalar S. Joao between 1996 and 2006 in which the pathology report mentioned the presence of SRCs (n= 11) and four mucinous carcinomas were included in the study. The frequency of SRCs and immunohistochemistry expression of MUC1/MUC2/MUC5AC/MUC6 were evaluated.We confirmed that SRC differentiation can occur in different histological types, including ductal, lobular, mucinous and metaplastic carcinomas. The proportion of SRCs was highly variable (range: 8-70%). Tumors encompassed SRCs of intracytoplasmic lumina and goblet-cell type. A higher percentage of SRCs was associated with lymphovascular invasion (p= 0.047). All tumors expressed cytoplasmic and membranous MUC1. Secretory mucins were more frequent in mucinous carcinomas and in carcinomas with extensive SRC differentiation.We conclude that besides the usefulness of mucin immunodetection for the differential diagnosis of carcinomas with SRC differentiation of breast origin, it is important to report SRC differentiation regardless of histological type because of its intrinsic prognostic value.Elsevier20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/119035eng0344-033810.1016/j.prp.2015.05.003Bartosch, CMendes, NRios, ERodrigues, MEloy, CReis, CAAmendoeira, Iinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:52:26Zoai:repositorio-aberto.up.pt:10216/119035Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:34:17.364410Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation |
title |
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation |
spellingShingle |
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation Bartosch, C Adult Aged Aged, 80 and over Biomarkers, Tumor/metabolism Breast Neoplasms/metabolism Breast Neoplasms/pathology Carcinoma, Signet Ring Cell/metabolism Cell Differentiation/physiology Cell Shape Female Humans Immunohistochemistry/methods Membrane Glycoproteins/metabolism Middle Aged Mucins/metabolism Stomach Neoplasms/metabolism Stomach Neoplasms/pathology |
title_short |
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation |
title_full |
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation |
title_fullStr |
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation |
title_full_unstemmed |
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation |
title_sort |
Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation |
author |
Bartosch, C |
author_facet |
Bartosch, C Mendes, N Rios, E Rodrigues, M Eloy, C Reis, CA Amendoeira, I |
author_role |
author |
author2 |
Mendes, N Rios, E Rodrigues, M Eloy, C Reis, CA Amendoeira, I |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Bartosch, C Mendes, N Rios, E Rodrigues, M Eloy, C Reis, CA Amendoeira, I |
dc.subject.por.fl_str_mv |
Adult Aged Aged, 80 and over Biomarkers, Tumor/metabolism Breast Neoplasms/metabolism Breast Neoplasms/pathology Carcinoma, Signet Ring Cell/metabolism Cell Differentiation/physiology Cell Shape Female Humans Immunohistochemistry/methods Membrane Glycoproteins/metabolism Middle Aged Mucins/metabolism Stomach Neoplasms/metabolism Stomach Neoplasms/pathology |
topic |
Adult Aged Aged, 80 and over Biomarkers, Tumor/metabolism Breast Neoplasms/metabolism Breast Neoplasms/pathology Carcinoma, Signet Ring Cell/metabolism Cell Differentiation/physiology Cell Shape Female Humans Immunohistochemistry/methods Membrane Glycoproteins/metabolism Middle Aged Mucins/metabolism Stomach Neoplasms/metabolism Stomach Neoplasms/pathology |
description |
Signet-ring cells are relatively common in breast cancers but are frequently overlooked. Although previously defined as a subtype of mucin producing carcinomas, breast carcinomas with signet-ring cell (SRC) differentiation nowadays are not considered a distinct entity.The objective of the present study was to characterize the morphological features and mucin expression profile of breast carcinomas with SRC differentiation. All breast carcinomas diagnosed at Centro Hospitalar S. Joao between 1996 and 2006 in which the pathology report mentioned the presence of SRCs (n= 11) and four mucinous carcinomas were included in the study. The frequency of SRCs and immunohistochemistry expression of MUC1/MUC2/MUC5AC/MUC6 were evaluated.We confirmed that SRC differentiation can occur in different histological types, including ductal, lobular, mucinous and metaplastic carcinomas. The proportion of SRCs was highly variable (range: 8-70%). Tumors encompassed SRCs of intracytoplasmic lumina and goblet-cell type. A higher percentage of SRCs was associated with lymphovascular invasion (p= 0.047). All tumors expressed cytoplasmic and membranous MUC1. Secretory mucins were more frequent in mucinous carcinomas and in carcinomas with extensive SRC differentiation.We conclude that besides the usefulness of mucin immunodetection for the differential diagnosis of carcinomas with SRC differentiation of breast origin, it is important to report SRC differentiation regardless of histological type because of its intrinsic prognostic value. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/119035 |
url |
https://hdl.handle.net/10216/119035 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0344-0338 10.1016/j.prp.2015.05.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136251598602240 |