The resting-brain of obsessive-compulsive disorder
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/62408 |
Resumo: | Obsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients’ daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks. |
id |
RCAP_fb5267bbb6913311dfca34b72a45d832 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/62408 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
The resting-brain of obsessive-compulsive disorderObsessive-compulsive disorderResting-state networksFMRIScience & TechnologyObsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients’ daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.Pedro Silva Moreira was supported by the FCT fellowship grant with the number PDE/BDE/113601/2015 from the PhD-iHES program; Paulo Marques was funded by the Fundação Calouste Gulbenkian (Contract grant number: P-139977; project “Better mental health during ageing based on temporal prediction of individual brain ageing trajectories (TEMPO)”); Ricardo Magalhães was supported by the FCT fellowship grant with the number PDE/BDE/113604/2015 from the PhD-iHES program; Madalena Esteves was supported by the FCT fellowship grant with the number SFRH/BD/52291/2013 from the PhDOC program. The present work was supported by SwitchBox-FP7-HEALTH2010-grant 259772-2 and co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER).ElsevierUniversidade do MinhoMoreira, Pedro SilvaMarques, PauloMagalhães, RicardoEsteves, MadalenaSousa, NunoSoares, José MiguelMorgado, Pedro2019-08-302019-08-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62408eng0925-492710.1016/j.pscychresns.2019.06.00831279239info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:04:52Zoai:repositorium.sdum.uminho.pt:1822/62408Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:55:12.508641Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The resting-brain of obsessive-compulsive disorder |
title |
The resting-brain of obsessive-compulsive disorder |
spellingShingle |
The resting-brain of obsessive-compulsive disorder Moreira, Pedro Silva Obsessive-compulsive disorder Resting-state networks FMRI Science & Technology |
title_short |
The resting-brain of obsessive-compulsive disorder |
title_full |
The resting-brain of obsessive-compulsive disorder |
title_fullStr |
The resting-brain of obsessive-compulsive disorder |
title_full_unstemmed |
The resting-brain of obsessive-compulsive disorder |
title_sort |
The resting-brain of obsessive-compulsive disorder |
author |
Moreira, Pedro Silva |
author_facet |
Moreira, Pedro Silva Marques, Paulo Magalhães, Ricardo Esteves, Madalena Sousa, Nuno Soares, José Miguel Morgado, Pedro |
author_role |
author |
author2 |
Marques, Paulo Magalhães, Ricardo Esteves, Madalena Sousa, Nuno Soares, José Miguel Morgado, Pedro |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Moreira, Pedro Silva Marques, Paulo Magalhães, Ricardo Esteves, Madalena Sousa, Nuno Soares, José Miguel Morgado, Pedro |
dc.subject.por.fl_str_mv |
Obsessive-compulsive disorder Resting-state networks FMRI Science & Technology |
topic |
Obsessive-compulsive disorder Resting-state networks FMRI Science & Technology |
description |
Obsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients’ daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-30 2019-08-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/62408 |
url |
http://hdl.handle.net/1822/62408 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0925-4927 10.1016/j.pscychresns.2019.06.008 31279239 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132336533536768 |