Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/7584 |
Resumo: | Funding :This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and under the project LA/P/0069/2020 granted to the Associate Laboratory ARNET, also through UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-fnanced by COMPETE (POCI01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-fnanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). |
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Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcataAntioxidantsMitochondrial dysfunctionNeuroinflammationParkinson's diseaseSH-SY5Y cellsRAW 264.7 cellsPhaeophyceaeFunding :This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and under the project LA/P/0069/2020 granted to the Associate Laboratory ARNET, also through UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-fnanced by COMPETE (POCI01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-fnanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).Oxidative stress is strongly involved in the pathogenesis of neurodegenerative diseases, like Parkinson´s disease (PD). Particularly, an excess of reactive oxygen species (ROS) released by the cells promotes an oxidative stress condition, which is a main cause of tissue injury leading to nervous system dysfunction. In this work, the antioxidant, neuroprotective and antiinflammatory activities of different fractions from the brown seaweed Bifurcaria bifurcata are presented and related with their chemical profile. The antioxidant capacity was evaluated by the Folin-Ciocalteu method, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) assays. Neuroprotective capacity was evaluated to prevent neurological cell death mediated by the neurotoxin 6-hydroxydopamine (6-OHDA) on SH-SY5Y cells, and their anti-inflammatory effects on RAW 264.7 macrophages. The ethyl acetate fractions (100 μg mL−1) exhibited significant antioxidant and neuroprotective activities in the in vitro models assayed. Furthermore, two of the most polar fractions obtained with methanol and water also evidenced a significant neuroprotective potential. Bifurcaria bifurcata fractions treatment decreased ROS production, mitochondrial dysfunction, and Caspase-3 activity. Regarding the anti-inflammatory potential, five fractions (100 μg mL−1) inhibited nitric oxide (NO) production and reduced the interleukin – 6 (IL-6) and tumor necrosis factor (TNF-α) levels. Mannitol, identified as the major component of the most bioactive fraction, protected SH-SY5Y cells against the 6-OHDA neurotoxicity mediating ROS generation mitigation, mitochondrial dysfunction, and DNA damage, together with the Caspase-3 activity inhibition. Results suggest that B. bifurcata is a relevant source of neuroprotective agents, with particular interest for preventive therapeutics.SpringerIC-OnlineSilva, JoanaAlves, CelsoSusano, PatríciaMartins, AlicePinteus, SuseteGaspar, HelenaAlfonso, AmparoPedrosa, Rui2022-08-23T13:34:22Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/7584engSilva, J., Alves, C., Susano, P. et al. Exploring marine resources against neurological disorders– the neuroprotective and anti-inflammatory potential of the brown seaweed Bifurcaria bifurcata. J Appl Phycol (2022). https://doi.org/10.1007/s10811-022-02794-z1573-517610.1007/s10811-022-02794-zmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:55:31Zoai:iconline.ipleiria.pt:10400.8/7584Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:50:30.983852Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata |
title |
Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata |
spellingShingle |
Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata Silva, Joana Antioxidants Mitochondrial dysfunction Neuroinflammation Parkinson's disease SH-SY5Y cells RAW 264.7 cells Phaeophyceae |
title_short |
Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata |
title_full |
Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata |
title_fullStr |
Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata |
title_full_unstemmed |
Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata |
title_sort |
Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata |
author |
Silva, Joana |
author_facet |
Silva, Joana Alves, Celso Susano, Patrícia Martins, Alice Pinteus, Susete Gaspar, Helena Alfonso, Amparo Pedrosa, Rui |
author_role |
author |
author2 |
Alves, Celso Susano, Patrícia Martins, Alice Pinteus, Susete Gaspar, Helena Alfonso, Amparo Pedrosa, Rui |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Silva, Joana Alves, Celso Susano, Patrícia Martins, Alice Pinteus, Susete Gaspar, Helena Alfonso, Amparo Pedrosa, Rui |
dc.subject.por.fl_str_mv |
Antioxidants Mitochondrial dysfunction Neuroinflammation Parkinson's disease SH-SY5Y cells RAW 264.7 cells Phaeophyceae |
topic |
Antioxidants Mitochondrial dysfunction Neuroinflammation Parkinson's disease SH-SY5Y cells RAW 264.7 cells Phaeophyceae |
description |
Funding :This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and under the project LA/P/0069/2020 granted to the Associate Laboratory ARNET, also through UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-fnanced by COMPETE (POCI01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-fnanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-23T13:34:22Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/7584 |
url |
http://hdl.handle.net/10400.8/7584 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva, J., Alves, C., Susano, P. et al. Exploring marine resources against neurological disorders– the neuroprotective and anti-inflammatory potential of the brown seaweed Bifurcaria bifurcata. J Appl Phycol (2022). https://doi.org/10.1007/s10811-022-02794-z 1573-5176 10.1007/s10811-022-02794-z |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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