Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata

Detalhes bibliográficos
Autor(a) principal: Silva, Joana
Data de Publicação: 2022
Outros Autores: Alves, Celso, Susano, Patrícia, Martins, Alice, Pinteus, Susete, Gaspar, Helena, Alfonso, Amparo, Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/7584
Resumo: Funding :This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and under the project LA/P/0069/2020 granted to the Associate Laboratory ARNET, also through UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-fnanced by COMPETE (POCI01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-fnanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).
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spelling Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcataAntioxidantsMitochondrial dysfunctionNeuroinflammationParkinson's diseaseSH-SY5Y cellsRAW 264.7 cellsPhaeophyceaeFunding :This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and under the project LA/P/0069/2020 granted to the Associate Laboratory ARNET, also through UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-fnanced by COMPETE (POCI01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-fnanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).Oxidative stress is strongly involved in the pathogenesis of neurodegenerative diseases, like Parkinson´s disease (PD). Particularly, an excess of reactive oxygen species (ROS) released by the cells promotes an oxidative stress condition, which is a main cause of tissue injury leading to nervous system dysfunction. In this work, the antioxidant, neuroprotective and antiinflammatory activities of different fractions from the brown seaweed Bifurcaria bifurcata are presented and related with their chemical profile. The antioxidant capacity was evaluated by the Folin-Ciocalteu method, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) assays. Neuroprotective capacity was evaluated to prevent neurological cell death mediated by the neurotoxin 6-hydroxydopamine (6-OHDA) on SH-SY5Y cells, and their anti-inflammatory effects on RAW 264.7 macrophages. The ethyl acetate fractions (100 μg mL−1) exhibited significant antioxidant and neuroprotective activities in the in vitro models assayed. Furthermore, two of the most polar fractions obtained with methanol and water also evidenced a significant neuroprotective potential. Bifurcaria bifurcata fractions treatment decreased ROS production, mitochondrial dysfunction, and Caspase-3 activity. Regarding the anti-inflammatory potential, five fractions (100 μg mL−1) inhibited nitric oxide (NO) production and reduced the interleukin – 6 (IL-6) and tumor necrosis factor (TNF-α) levels. Mannitol, identified as the major component of the most bioactive fraction, protected SH-SY5Y cells against the 6-OHDA neurotoxicity mediating ROS generation mitigation, mitochondrial dysfunction, and DNA damage, together with the Caspase-3 activity inhibition. Results suggest that B. bifurcata is a relevant source of neuroprotective agents, with particular interest for preventive therapeutics.SpringerIC-OnlineSilva, JoanaAlves, CelsoSusano, PatríciaMartins, AlicePinteus, SuseteGaspar, HelenaAlfonso, AmparoPedrosa, Rui2022-08-23T13:34:22Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/7584engSilva, J., Alves, C., Susano, P. et al. Exploring marine resources against neurological disorders– the neuroprotective and anti-inflammatory potential of the brown seaweed Bifurcaria bifurcata. J Appl Phycol (2022). https://doi.org/10.1007/s10811-022-02794-z1573-517610.1007/s10811-022-02794-zmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:55:31Zoai:iconline.ipleiria.pt:10400.8/7584Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:50:30.983852Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
title Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
spellingShingle Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
Silva, Joana
Antioxidants
Mitochondrial dysfunction
Neuroinflammation
Parkinson's disease
SH-SY5Y cells
RAW 264.7 cells
Phaeophyceae
title_short Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
title_full Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
title_fullStr Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
title_full_unstemmed Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
title_sort Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata
author Silva, Joana
author_facet Silva, Joana
Alves, Celso
Susano, Patrícia
Martins, Alice
Pinteus, Susete
Gaspar, Helena
Alfonso, Amparo
Pedrosa, Rui
author_role author
author2 Alves, Celso
Susano, Patrícia
Martins, Alice
Pinteus, Susete
Gaspar, Helena
Alfonso, Amparo
Pedrosa, Rui
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Silva, Joana
Alves, Celso
Susano, Patrícia
Martins, Alice
Pinteus, Susete
Gaspar, Helena
Alfonso, Amparo
Pedrosa, Rui
dc.subject.por.fl_str_mv Antioxidants
Mitochondrial dysfunction
Neuroinflammation
Parkinson's disease
SH-SY5Y cells
RAW 264.7 cells
Phaeophyceae
topic Antioxidants
Mitochondrial dysfunction
Neuroinflammation
Parkinson's disease
SH-SY5Y cells
RAW 264.7 cells
Phaeophyceae
description Funding :This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and under the project LA/P/0069/2020 granted to the Associate Laboratory ARNET, also through UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-fnanced by COMPETE (POCI01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-fnanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).
publishDate 2022
dc.date.none.fl_str_mv 2022-08-23T13:34:22Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/7584
url http://hdl.handle.net/10400.8/7584
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, J., Alves, C., Susano, P. et al. Exploring marine resources against neurological disorders– the neuroprotective and anti-inflammatory potential of the brown seaweed Bifurcaria bifurcata. J Appl Phycol (2022). https://doi.org/10.1007/s10811-022-02794-z
1573-5176
10.1007/s10811-022-02794-z
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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