Macrophage and epithelial cell H-ferritin expression regulates renal inflammation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/770 |
Resumo: | The deposited article is a post-print version (author's manuscript from PMC). |
| id |
RCAP_fbe23e7e0ec63742942fb75e71f7a411 |
|---|---|
| oai_identifier_str |
oai:arca.igc.gulbenkian.pt:10400.7/770 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammationAnimalsApoferritinsCells, CulturedChemokine CCL2Disease Models, AnimalEpithelial CellsFibrosisGene ExpressionHeme Oxygenase-1Interleukin-10Interleukin-6KidneyKidney Tubules, ProximalMacrophage ActivationMacrophage Colony-Stimulating FactorMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicMyeloid CellsNephritisRNA, MessengerUreteral ObstructionThe deposited article is a post-print version (author's manuscript from PMC).This publication hasn't any creative commons license associated.The deposited article version contains attached the supplementary materials within the pdf.Inflammation culminating in fibrosis contributes to progressive kidney disease. Cross-talk between the tubular epithelium and interstitial cells regulates inflammation by a coordinated release of cytokines and chemokines. Here we studied the role of heme oxygenase-1 (HO-1) and the heavy subunit of ferritin (FtH) in macrophage polarization and renal inflammation. Deficiency in HO-1 was associated with increased FtH expression, accumulation of macrophages with a dysregulated polarization profile, and increased fibrosis following unilateral ureteral obstruction in mice: a model of renal inflammation and fibrosis. Macrophage polarization in vitro was predominantly dependent on FtH expression in isolated bone marrow-derived mouse monocytes. Using transgenic mice with conditional deletion of FtH in the proximal tubules (FtH(PT-/-)) or myeloid cells (FtH(LysM-/-)), we found that myeloid FtH deficiency did not affect polarization or accumulation of macrophages in the injured kidney compared with wild-type (FtH(+/+)) controls. However, tubular FtH deletion led to a marked increase in proinflammatory macrophages. Furthermore, injured kidneys from FtH(PT-/-) mice expressed significantly higher levels of inflammatory chemokines and fibrosis compared with kidneys from FtH(+/+) and FtH(LysM-/-) mice. Thus, there are differential effects of FtH in macrophages and epithelial cells, which underscore the critical role of FtH in tubular-macrophage cross-talk during kidney injury.NIH grants: (R01 DK5960, R01 DK5960, P30 DK079337, R01 DK083390); Fundação para a Ciência e Tecnologia grants: (PTDC/SAU-TOX/116627/2010, HMSP-ICT/0022/2010); European Union grant: (ERC-2011-AdG. 294709 DAMAGECONTROL); AHA grant: (11POST7600074).ElsevierARCABolisetty, SubhashiniZarjou, AbolfazlHull, Travis D.Traylor, Amie M.Perianayagam, AnjanaJoseph, RenyKamal, Ahmed I.Arosio, PaoloSoares, Miguel P.Jeney, ViktoriaBalla, JozsefGeorge, James F.Agarwal, Anupam2017-06-22T17:39:58Z2015-04-152015-04-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/770engSubhashini Bolisetty, Abolfazl Zarjou, Travis D. Hull, Amie M. Traylor, Anjana Perianayagam, Reny Joseph, Ahmed I. Kamal, Paolo Arosio, Miguel P. Soares, Viktoria Jeney, Jozsef Balla, James F. George, Anupam Agarwal, Macrophage and epithelial cell H-ferritin expression regulates renal inflammation, Kidney International, Volume 88, Issue 1, 2015, Pages 95-108, ISSN 0085-2538, http://dx.doi.org/10.1038/ki.2015.102. (http://www.sciencedirect.com/science/article/pii/S2157171615321183) Keywords: acute kidney injury; ferritin; fibrosis; inflammation; macrophage polarization10.1038/ki.2015.102info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:10Zoai:arca.igc.gulbenkian.pt:10400.7/770Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:59.802951Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation |
| title |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation |
| spellingShingle |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation Bolisetty, Subhashini Animals Apoferritins Cells, Cultured Chemokine CCL2 Disease Models, Animal Epithelial Cells Fibrosis Gene Expression Heme Oxygenase-1 Interleukin-10 Interleukin-6 Kidney Kidney Tubules, Proximal Macrophage Activation Macrophage Colony-Stimulating Factor Macrophages Male Mice Mice, Inbred C57BL Mice, Transgenic Myeloid Cells Nephritis RNA, Messenger Ureteral Obstruction |
| title_short |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation |
| title_full |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation |
| title_fullStr |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation |
| title_full_unstemmed |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation |
| title_sort |
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation |
| author |
Bolisetty, Subhashini |
| author_facet |
Bolisetty, Subhashini Zarjou, Abolfazl Hull, Travis D. Traylor, Amie M. Perianayagam, Anjana Joseph, Reny Kamal, Ahmed I. Arosio, Paolo Soares, Miguel P. Jeney, Viktoria Balla, Jozsef George, James F. Agarwal, Anupam |
| author_role |
author |
| author2 |
Zarjou, Abolfazl Hull, Travis D. Traylor, Amie M. Perianayagam, Anjana Joseph, Reny Kamal, Ahmed I. Arosio, Paolo Soares, Miguel P. Jeney, Viktoria Balla, Jozsef George, James F. Agarwal, Anupam |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Bolisetty, Subhashini Zarjou, Abolfazl Hull, Travis D. Traylor, Amie M. Perianayagam, Anjana Joseph, Reny Kamal, Ahmed I. Arosio, Paolo Soares, Miguel P. Jeney, Viktoria Balla, Jozsef George, James F. Agarwal, Anupam |
| dc.subject.por.fl_str_mv |
Animals Apoferritins Cells, Cultured Chemokine CCL2 Disease Models, Animal Epithelial Cells Fibrosis Gene Expression Heme Oxygenase-1 Interleukin-10 Interleukin-6 Kidney Kidney Tubules, Proximal Macrophage Activation Macrophage Colony-Stimulating Factor Macrophages Male Mice Mice, Inbred C57BL Mice, Transgenic Myeloid Cells Nephritis RNA, Messenger Ureteral Obstruction |
| topic |
Animals Apoferritins Cells, Cultured Chemokine CCL2 Disease Models, Animal Epithelial Cells Fibrosis Gene Expression Heme Oxygenase-1 Interleukin-10 Interleukin-6 Kidney Kidney Tubules, Proximal Macrophage Activation Macrophage Colony-Stimulating Factor Macrophages Male Mice Mice, Inbred C57BL Mice, Transgenic Myeloid Cells Nephritis RNA, Messenger Ureteral Obstruction |
| description |
The deposited article is a post-print version (author's manuscript from PMC). |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-04-15 2015-04-15T00:00:00Z 2017-06-22T17:39:58Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/770 |
| url |
http://hdl.handle.net/10400.7/770 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Subhashini Bolisetty, Abolfazl Zarjou, Travis D. Hull, Amie M. Traylor, Anjana Perianayagam, Reny Joseph, Ahmed I. Kamal, Paolo Arosio, Miguel P. Soares, Viktoria Jeney, Jozsef Balla, James F. George, Anupam Agarwal, Macrophage and epithelial cell H-ferritin expression regulates renal inflammation, Kidney International, Volume 88, Issue 1, 2015, Pages 95-108, ISSN 0085-2538, http://dx.doi.org/10.1038/ki.2015.102. (http://www.sciencedirect.com/science/article/pii/S2157171615321183) Keywords: acute kidney injury; ferritin; fibrosis; inflammation; macrophage polarization 10.1038/ki.2015.102 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799130574814707712 |