Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort

Kissling, Esther; Pozo, Francisco; Buda, Silke; Vilcu, Ana-Maria; Gherasim, Alin; Brytting, Mia; Domegan, Lisa; Gómez, Verónica; Meijer, Adam; Lazar, Mihaela; Vučina, Vesna Višekruna; Dürrwald, Ralf; van der Werf, Sylvie; Larrauri, Amparo; Enkirch, Theresa; O’Donnell, Joan; Guiomar, Raquel; Hooiveld, Mariëtte; Petrović, Goranka; Stoian, Elena; Penttinen, Pasi; Valenciano, Marta; I-MOVE primary care study team

Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort

Detalhes bibliográficos
Autor(a) principal:	Kissling, Esther
Data de Publicação:	2019
Outros Autores:	Pozo, Francisco, Buda, Silke, Vilcu, Ana-Maria, Gherasim, Alin, Brytting, Mia, Domegan, Lisa, Gómez, Verónica, Meijer, Adam, Lazar, Mihaela, Vučina, Vesna Višekruna, Dürrwald, Ralf, van der Werf, Sylvie, Larrauri, Amparo, Enkirch, Theresa, O’Donnell, Joan, Guiomar, Raquel, Hooiveld, Mariëtte, Petrović, Goranka, Stoian, Elena, Penttinen, Pasi, Valenciano, Marta, I-MOVE primary care study team
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo:	http://hdl.handle.net/10400.18/6536
Resumo:	I-MOVE primary care study team (Portugal): Ana Paula Rodrigues, Ausenda Machado, Baltazar Nunes, Irina Kislaya, Inês Costa, Patrícia Conde, Paula Cristóvão, Pedro Pechirra, Vítor Borges

Metadados do item

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oai_identifier_str	oai:repositorio.insa.pt:10400.18/6536
network_acronym_str	RCAP
network_name_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str	7160
spelling	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohortInfluenzaA(H3N2)ImprintingDeterminantes de Saúde e DoençaEstado de Saúde e DoençaGripeVacina AntigripalEuroEVAEfetividadeÉpoca 2018-2019I-MOVE primary care study team (Portugal): Ana Paula Rodrigues, Ausenda Machado, Baltazar Nunes, Irina Kislaya, Inês Costa, Patrícia Conde, Paula Cristóvão, Pedro Pechirra, Vítor BorgesIntroduction: Influenza A(H3N2) clades 3C.2a and 3C.3a co-circulated in Europe in 2018/19. Immunological imprinting by first childhood influenza infection may induce future birth cohort differences in vaccine effectiveness (VE). Aim: The I-MOVE multicentre primary care test-negative study assessed 2018/19 influenza A(H3N2) VE by age and genetic subgroups to explore VE by birth cohort. Methods: We measured VE against influenza A(H3N2) and (sub)clades. We stratified VE by usual age groups (0–14, 15–64, ≥ 65-years). To assess the imprint-regulated effect of vaccine (I-REV) hypothesis, we further stratified the middle-aged group, notably including 32–54-year-olds (1964–86) sharing potential childhood imprinting to serine at haemagglutinin position 159. Results: Influenza A(H3N2) VE among all ages was −1% (95% confidence interval (CI): −24 to 18) and 46% (95% CI: 8–68), −26% (95% CI: −66 to 4) and 20% (95% CI: −20 to 46) among 0–14, 15–64 and ≥ 65-year-olds, respectively. Among 15–64-year-olds, VE against clades 3C.2a1b and 3C.3a was 15% (95% CI: −34 to 50) and −74% (95% CI: −259 to 16), respectively. VE was −18% (95% CI: −140 to 41), −53% (95% CI: −131 to −2) and −12% (95% CI: −74 to 28) among 15–31-year-olds (1987–2003), 32–54-yearolds (1964–86) and 55–64-year-olds (1954–63), respectively. Discussion: The lowest 2018/19 influenza A(H3N2) VE was against clade 3C.3a and among those born 1964–86, corresponding to the I-REV hypothesis. The low influenza A(H3N2) VE in 15–64-year-olds and the public health impact of the I-REV hypothesis warrant further study.ECDCEuropean Centre for Disease Prevention and ControlRepositório Científico do Instituto Nacional de SaúdeKissling, EstherPozo, FranciscoBuda, SilkeVilcu, Ana-MariaGherasim, AlinBrytting, MiaDomegan, LisaGómez, VerónicaMeijer, AdamLazar, MihaelaVučina, Vesna VišekrunaDürrwald, Ralfvan der Werf, SylvieLarrauri, AmparoEnkirch, TheresaO’Donnell, JoanGuiomar, RaquelHooiveld, MariëttePetrović, GorankaStoian, ElenaPenttinen, PasiValenciano, MartaI-MOVE primary care study team2020-04-27T19:02:18Z2019-11-282019-11-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6536engEuro Surveill. 2019 Nov;24(48):1900604. doi: 10.2807/1560-7917.ES.2019.24.48.19006041560-791710.2807/1560-7917.ES.2019.24.48.1900604info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:32Zoai:repositorio.insa.pt:10400.18/6536Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:17.174501Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort
title	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort
spellingShingle	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort Kissling, Esther Influenza A(H3N2) Imprinting Determinantes de Saúde e Doença Estado de Saúde e Doença Gripe Vacina Antigripal EuroEVA Efetividade Época 2018-2019
title_short	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort
title_full	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort
title_fullStr	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort
title_full_unstemmed	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort
title_sort	Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort
author	Kissling, Esther
author_facet	Kissling, Esther Pozo, Francisco Buda, Silke Vilcu, Ana-Maria Gherasim, Alin Brytting, Mia Domegan, Lisa Gómez, Verónica Meijer, Adam Lazar, Mihaela Vučina, Vesna Višekruna Dürrwald, Ralf van der Werf, Sylvie Larrauri, Amparo Enkirch, Theresa O’Donnell, Joan Guiomar, Raquel Hooiveld, Mariëtte Petrović, Goranka Stoian, Elena Penttinen, Pasi Valenciano, Marta I-MOVE primary care study team
author_role	author
author2	Pozo, Francisco Buda, Silke Vilcu, Ana-Maria Gherasim, Alin Brytting, Mia Domegan, Lisa Gómez, Verónica Meijer, Adam Lazar, Mihaela Vučina, Vesna Višekruna Dürrwald, Ralf van der Werf, Sylvie Larrauri, Amparo Enkirch, Theresa O’Donnell, Joan Guiomar, Raquel Hooiveld, Mariëtte Petrović, Goranka Stoian, Elena Penttinen, Pasi Valenciano, Marta I-MOVE primary care study team
author2_role	author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv	Kissling, Esther Pozo, Francisco Buda, Silke Vilcu, Ana-Maria Gherasim, Alin Brytting, Mia Domegan, Lisa Gómez, Verónica Meijer, Adam Lazar, Mihaela Vučina, Vesna Višekruna Dürrwald, Ralf van der Werf, Sylvie Larrauri, Amparo Enkirch, Theresa O’Donnell, Joan Guiomar, Raquel Hooiveld, Mariëtte Petrović, Goranka Stoian, Elena Penttinen, Pasi Valenciano, Marta I-MOVE primary care study team
dc.subject.por.fl_str_mv	Influenza A(H3N2) Imprinting Determinantes de Saúde e Doença Estado de Saúde e Doença Gripe Vacina Antigripal EuroEVA Efetividade Época 2018-2019
topic	Influenza A(H3N2) Imprinting Determinantes de Saúde e Doença Estado de Saúde e Doença Gripe Vacina Antigripal EuroEVA Efetividade Época 2018-2019
description	I-MOVE primary care study team (Portugal): Ana Paula Rodrigues, Ausenda Machado, Baltazar Nunes, Irina Kislaya, Inês Costa, Patrícia Conde, Paula Cristóvão, Pedro Pechirra, Vítor Borges
publishDate	2019
dc.date.none.fl_str_mv	2019-11-28 2019-11-28T00:00:00Z 2020-04-27T19:02:18Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10400.18/6536
url	http://hdl.handle.net/10400.18/6536
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Euro Surveill. 2019 Nov;24(48):1900604. doi: 10.2807/1560-7917.ES.2019.24.48.1900604 1560-7917 10.2807/1560-7917.ES.2019.24.48.1900604
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	European Centre for Disease Prevention and Control
publisher.none.fl_str_mv	European Centre for Disease Prevention and Control
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str	RCAAP
institution	RCAAP
reponame_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort

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