Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/12408 |
Resumo: | Chemical composition and biological properties of aqueous and ethanolic extracts of Inonotus obliquus (Pers.:Fr.) Pilat from different origins, i.e. of Finland, Russia, and Thailand, were studied. Concerning biological activity, antimicrobial, antiqourum, antioxidative, and antitumor and cytotoxic effects were tested. Oxalic acid was found as the main organic acid, with the highest amount in Russian aqueous extract. Gallic, protocatechuic and p-hydroxybenzoic acids were detected in all samples. I. obliquus extracts showed high antioxidant and antimicrobial activity. Extracts were tested at subMIC for anti-quorum sensing (AQS) activity in Pseudomonas aeruginosa and all of them showed definite AQS activity. The assays were done using twitching and swarming of bacterial cultures, as well as the amount of produced pyocyanin as QS parameters. All the extracts possessed good antitumor effect on four cells lines and did not show hepatotoxicity on porcine liver primary cells designed as PLP2. As the I. obliquus presence in Chaga conks is limited, further purification is necessary to draw quantitative conclusions. The presence of AQS activity in medicinal mushrooms suggests a broader anti-infectious disease protection than only immunomodulatory effects. |
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Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”Inonotus obliquusChemical characterizationAntioxidant propertiesAntimicrobial activityAntiquorum effectAntitumor activityChemical composition and biological properties of aqueous and ethanolic extracts of Inonotus obliquus (Pers.:Fr.) Pilat from different origins, i.e. of Finland, Russia, and Thailand, were studied. Concerning biological activity, antimicrobial, antiqourum, antioxidative, and antitumor and cytotoxic effects were tested. Oxalic acid was found as the main organic acid, with the highest amount in Russian aqueous extract. Gallic, protocatechuic and p-hydroxybenzoic acids were detected in all samples. I. obliquus extracts showed high antioxidant and antimicrobial activity. Extracts were tested at subMIC for anti-quorum sensing (AQS) activity in Pseudomonas aeruginosa and all of them showed definite AQS activity. The assays were done using twitching and swarming of bacterial cultures, as well as the amount of produced pyocyanin as QS parameters. All the extracts possessed good antitumor effect on four cells lines and did not show hepatotoxicity on porcine liver primary cells designed as PLP2. As the I. obliquus presence in Chaga conks is limited, further purification is necessary to draw quantitative conclusions. The presence of AQS activity in medicinal mushrooms suggests a broader anti-infectious disease protection than only immunomodulatory effects.The authors are grateful to Serbian Ministry of Education, Science and Technological Development for financial support (grant number 173032), to Foundation for Science and Technology (FCT, Portugal) and COMPETE/QREN/EU for financial support to CIMO strategic project PEst-OE/AGR/UI0690/2011, L. Barros contract, A. Fernandes (SFRH/BD/76019/2011) and R.C. Calhelha (SFRH/BPD/68344/2010) grants.ElsevierBiblioteca Digital do IPBGlamočlija, JasminaĆirić, AnaNikolić, MilošFernandes, ÂngelaBarros, LillianCalhelha, Ricardo C.Ferreira, Isabel C.F.R.Soković, MarinaVan Griensven, Leo J.L.D.2015-11-24T15:02:20Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10198/12408engGlamočlija, Jasmina; Ćirić, Ana; Nikolić, Miloš; Fernandes, Ângela; Barros, Lillian; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Soković, Marina; van Griensven, Leo J.L.D. (2015). Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”. Journal of Ethnopharmacology. ISSN 0378-8741. 162, p. 323-3320378-874110.1016/j.jep.2014.12.069info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:28:31Zoai:bibliotecadigital.ipb.pt:10198/12408Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:02:33.552484Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom” |
title |
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom” |
spellingShingle |
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom” Glamočlija, Jasmina Inonotus obliquus Chemical characterization Antioxidant properties Antimicrobial activity Antiquorum effect Antitumor activity |
title_short |
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom” |
title_full |
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom” |
title_fullStr |
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom” |
title_full_unstemmed |
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom” |
title_sort |
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom” |
author |
Glamočlija, Jasmina |
author_facet |
Glamočlija, Jasmina Ćirić, Ana Nikolić, Miloš Fernandes, Ângela Barros, Lillian Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Soković, Marina Van Griensven, Leo J.L.D. |
author_role |
author |
author2 |
Ćirić, Ana Nikolić, Miloš Fernandes, Ângela Barros, Lillian Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Soković, Marina Van Griensven, Leo J.L.D. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Glamočlija, Jasmina Ćirić, Ana Nikolić, Miloš Fernandes, Ângela Barros, Lillian Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Soković, Marina Van Griensven, Leo J.L.D. |
dc.subject.por.fl_str_mv |
Inonotus obliquus Chemical characterization Antioxidant properties Antimicrobial activity Antiquorum effect Antitumor activity |
topic |
Inonotus obliquus Chemical characterization Antioxidant properties Antimicrobial activity Antiquorum effect Antitumor activity |
description |
Chemical composition and biological properties of aqueous and ethanolic extracts of Inonotus obliquus (Pers.:Fr.) Pilat from different origins, i.e. of Finland, Russia, and Thailand, were studied. Concerning biological activity, antimicrobial, antiqourum, antioxidative, and antitumor and cytotoxic effects were tested. Oxalic acid was found as the main organic acid, with the highest amount in Russian aqueous extract. Gallic, protocatechuic and p-hydroxybenzoic acids were detected in all samples. I. obliquus extracts showed high antioxidant and antimicrobial activity. Extracts were tested at subMIC for anti-quorum sensing (AQS) activity in Pseudomonas aeruginosa and all of them showed definite AQS activity. The assays were done using twitching and swarming of bacterial cultures, as well as the amount of produced pyocyanin as QS parameters. All the extracts possessed good antitumor effect on four cells lines and did not show hepatotoxicity on porcine liver primary cells designed as PLP2. As the I. obliquus presence in Chaga conks is limited, further purification is necessary to draw quantitative conclusions. The presence of AQS activity in medicinal mushrooms suggests a broader anti-infectious disease protection than only immunomodulatory effects. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-11-24T15:02:20Z 2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/12408 |
url |
http://hdl.handle.net/10198/12408 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Glamočlija, Jasmina; Ćirić, Ana; Nikolić, Miloš; Fernandes, Ângela; Barros, Lillian; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Soković, Marina; van Griensven, Leo J.L.D. (2015). Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”. Journal of Ethnopharmacology. ISSN 0378-8741. 162, p. 323-332 0378-8741 10.1016/j.jep.2014.12.069 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135265049018368 |