Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”

Detalhes bibliográficos
Autor(a) principal: Glamočlija, Jasmina
Data de Publicação: 2015
Outros Autores: Ćirić, Ana, Nikolić, Miloš, Fernandes, Ângela, Barros, Lillian, Calhelha, Ricardo C., Ferreira, Isabel C.F.R., Soković, Marina, Van Griensven, Leo J.L.D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/12408
Resumo: Chemical composition and biological properties of aqueous and ethanolic extracts of Inonotus obliquus (Pers.:Fr.) Pilat from different origins, i.e. of Finland, Russia, and Thailand, were studied. Concerning biological activity, antimicrobial, antiqourum, antioxidative, and antitumor and cytotoxic effects were tested. Oxalic acid was found as the main organic acid, with the highest amount in Russian aqueous extract. Gallic, protocatechuic and p-hydroxybenzoic acids were detected in all samples. I. obliquus extracts showed high antioxidant and antimicrobial activity. Extracts were tested at subMIC for anti-quorum sensing (AQS) activity in Pseudomonas aeruginosa and all of them showed definite AQS activity. The assays were done using twitching and swarming of bacterial cultures, as well as the amount of produced pyocyanin as QS parameters. All the extracts possessed good antitumor effect on four cells lines and did not show hepatotoxicity on porcine liver primary cells designed as PLP2. As the I. obliquus presence in Chaga conks is limited, further purification is necessary to draw quantitative conclusions. The presence of AQS activity in medicinal mushrooms suggests a broader anti-infectious disease protection than only immunomodulatory effects.
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spelling Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”Inonotus obliquusChemical characterizationAntioxidant propertiesAntimicrobial activityAntiquorum effectAntitumor activityChemical composition and biological properties of aqueous and ethanolic extracts of Inonotus obliquus (Pers.:Fr.) Pilat from different origins, i.e. of Finland, Russia, and Thailand, were studied. Concerning biological activity, antimicrobial, antiqourum, antioxidative, and antitumor and cytotoxic effects were tested. Oxalic acid was found as the main organic acid, with the highest amount in Russian aqueous extract. Gallic, protocatechuic and p-hydroxybenzoic acids were detected in all samples. I. obliquus extracts showed high antioxidant and antimicrobial activity. Extracts were tested at subMIC for anti-quorum sensing (AQS) activity in Pseudomonas aeruginosa and all of them showed definite AQS activity. The assays were done using twitching and swarming of bacterial cultures, as well as the amount of produced pyocyanin as QS parameters. All the extracts possessed good antitumor effect on four cells lines and did not show hepatotoxicity on porcine liver primary cells designed as PLP2. As the I. obliquus presence in Chaga conks is limited, further purification is necessary to draw quantitative conclusions. The presence of AQS activity in medicinal mushrooms suggests a broader anti-infectious disease protection than only immunomodulatory effects.The authors are grateful to Serbian Ministry of Education, Science and Technological Development for financial support (grant number 173032), to Foundation for Science and Technology (FCT, Portugal) and COMPETE/QREN/EU for financial support to CIMO strategic project PEst-OE/AGR/UI0690/2011, L. Barros contract, A. Fernandes (SFRH/BD/76019/2011) and R.C. Calhelha (SFRH/BPD/68344/2010) grants.ElsevierBiblioteca Digital do IPBGlamočlija, JasminaĆirić, AnaNikolić, MilošFernandes, ÂngelaBarros, LillianCalhelha, Ricardo C.Ferreira, Isabel C.F.R.Soković, MarinaVan Griensven, Leo J.L.D.2015-11-24T15:02:20Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10198/12408engGlamočlija, Jasmina; Ćirić, Ana; Nikolić, Miloš; Fernandes, Ângela; Barros, Lillian; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Soković, Marina; van Griensven, Leo J.L.D. (2015). Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”. Journal of Ethnopharmacology. ISSN 0378-8741. 162, p. 323-3320378-874110.1016/j.jep.2014.12.069info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:28:31Zoai:bibliotecadigital.ipb.pt:10198/12408Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:02:33.552484Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
title Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
spellingShingle Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
Glamočlija, Jasmina
Inonotus obliquus
Chemical characterization
Antioxidant properties
Antimicrobial activity
Antiquorum effect
Antitumor activity
title_short Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
title_full Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
title_fullStr Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
title_full_unstemmed Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
title_sort Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
author Glamočlija, Jasmina
author_facet Glamočlija, Jasmina
Ćirić, Ana
Nikolić, Miloš
Fernandes, Ângela
Barros, Lillian
Calhelha, Ricardo C.
Ferreira, Isabel C.F.R.
Soković, Marina
Van Griensven, Leo J.L.D.
author_role author
author2 Ćirić, Ana
Nikolić, Miloš
Fernandes, Ângela
Barros, Lillian
Calhelha, Ricardo C.
Ferreira, Isabel C.F.R.
Soković, Marina
Van Griensven, Leo J.L.D.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Glamočlija, Jasmina
Ćirić, Ana
Nikolić, Miloš
Fernandes, Ângela
Barros, Lillian
Calhelha, Ricardo C.
Ferreira, Isabel C.F.R.
Soković, Marina
Van Griensven, Leo J.L.D.
dc.subject.por.fl_str_mv Inonotus obliquus
Chemical characterization
Antioxidant properties
Antimicrobial activity
Antiquorum effect
Antitumor activity
topic Inonotus obliquus
Chemical characterization
Antioxidant properties
Antimicrobial activity
Antiquorum effect
Antitumor activity
description Chemical composition and biological properties of aqueous and ethanolic extracts of Inonotus obliquus (Pers.:Fr.) Pilat from different origins, i.e. of Finland, Russia, and Thailand, were studied. Concerning biological activity, antimicrobial, antiqourum, antioxidative, and antitumor and cytotoxic effects were tested. Oxalic acid was found as the main organic acid, with the highest amount in Russian aqueous extract. Gallic, protocatechuic and p-hydroxybenzoic acids were detected in all samples. I. obliquus extracts showed high antioxidant and antimicrobial activity. Extracts were tested at subMIC for anti-quorum sensing (AQS) activity in Pseudomonas aeruginosa and all of them showed definite AQS activity. The assays were done using twitching and swarming of bacterial cultures, as well as the amount of produced pyocyanin as QS parameters. All the extracts possessed good antitumor effect on four cells lines and did not show hepatotoxicity on porcine liver primary cells designed as PLP2. As the I. obliquus presence in Chaga conks is limited, further purification is necessary to draw quantitative conclusions. The presence of AQS activity in medicinal mushrooms suggests a broader anti-infectious disease protection than only immunomodulatory effects.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-24T15:02:20Z
2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/12408
url http://hdl.handle.net/10198/12408
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Glamočlija, Jasmina; Ćirić, Ana; Nikolić, Miloš; Fernandes, Ângela; Barros, Lillian; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Soković, Marina; van Griensven, Leo J.L.D. (2015). Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”. Journal of Ethnopharmacology. ISSN 0378-8741. 162, p. 323-332
0378-8741
10.1016/j.jep.2014.12.069
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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