Analytical methods for honeybee venom characterization
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/26816 |
Resumo: | The discovery of new drugs has benefited significantly from the development of research in venomics, increasing our understanding of the envenomation processes. It has been previously reported that honeybee venom (HBV) exhibits several pharmacological activities such as anti‑inflammatory, antibacterial, antimutagenic, radioprotective, and anticancer activity and may inclusively act as a complementary treatment for SARS‑CoV‑2. It composition consists mainly on melittin, phospholipase A2, and apamin but other constituents such as hyaluronidase, mast cell degranulating peptide and secapin are also relevant for its bioactivity. However, and because HBV is not officially recognized as a drug, until now, the international community did not establish quality standards for it. To uncover its exact composition, and boost the discovery of HBV‑derived drugs, a significant number of techniques were developed. In this review, a relevant overview of the so far published analytical methods for HBV characterization is organized with the aim to accelerate its future standardization. The literature search was performed within PubMed, Google Scholar, and Science Direct by selecting specific documents and exploring HBV evaluation. |
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Analytical methods for honeybee venom characterizationAnalytical methodsApaminEnzymesMast cell degranulating peptidePeptidesVenomicsThe discovery of new drugs has benefited significantly from the development of research in venomics, increasing our understanding of the envenomation processes. It has been previously reported that honeybee venom (HBV) exhibits several pharmacological activities such as anti‑inflammatory, antibacterial, antimutagenic, radioprotective, and anticancer activity and may inclusively act as a complementary treatment for SARS‑CoV‑2. It composition consists mainly on melittin, phospholipase A2, and apamin but other constituents such as hyaluronidase, mast cell degranulating peptide and secapin are also relevant for its bioactivity. However, and because HBV is not officially recognized as a drug, until now, the international community did not establish quality standards for it. To uncover its exact composition, and boost the discovery of HBV‑derived drugs, a significant number of techniques were developed. In this review, a relevant overview of the so far published analytical methods for HBV characterization is organized with the aim to accelerate its future standardization. The literature search was performed within PubMed, Google Scholar, and Science Direct by selecting specific documents and exploring HBV evaluation.Thanks to the Foundation Science and Technology (FCT, Portugal) for support by national funds to CIMO (UIDB/00690/2020). The project PDR2020‑1.0.1‑FEADER‑031734: “DivInA‑Diversification and Innovation on Beekeeping Production” and to the European Regional Development Fund through the Regional Operational Program North 2020, within the scope of Project GreenHealth, Norte‑01‑0145‑FEDER‑000042. This research was also funded by (UI0204): UIDB/00313/2020, Center of Chemistry from Faculty of Sciences and Technology of University of Coimbra, Portugal.Wolters KluwerBiblioteca Digital do IPBMehdi, Iouraouine ElFalcão, SoraiaBoujraf, SaïdMustapha, HarandouCampos, Maria G.Vilas-Boas, Miguel2023-02-08T14:04:15Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/26816engMehdi, Iouraouine El; Falcão, Soraia; Boujraf, Saïd; Mustapha, Harandou; Campos, Maria G.; Vilas-Boas, Miguel (2022). Analytical methods for honeybee venom characterization. Journal of Advanced Pharmaceutical Technology & Research. ISSN 2231-4040. 13:3, p. 154-1602231-404010.4103/japtr.japtr_166_21info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:59:42Zoai:bibliotecadigital.ipb.pt:10198/26816Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:17:15.278551Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Analytical methods for honeybee venom characterization |
title |
Analytical methods for honeybee venom characterization |
spellingShingle |
Analytical methods for honeybee venom characterization Mehdi, Iouraouine El Analytical methods Apamin Enzymes Mast cell degranulating peptide Peptides Venomics |
title_short |
Analytical methods for honeybee venom characterization |
title_full |
Analytical methods for honeybee venom characterization |
title_fullStr |
Analytical methods for honeybee venom characterization |
title_full_unstemmed |
Analytical methods for honeybee venom characterization |
title_sort |
Analytical methods for honeybee venom characterization |
author |
Mehdi, Iouraouine El |
author_facet |
Mehdi, Iouraouine El Falcão, Soraia Boujraf, Saïd Mustapha, Harandou Campos, Maria G. Vilas-Boas, Miguel |
author_role |
author |
author2 |
Falcão, Soraia Boujraf, Saïd Mustapha, Harandou Campos, Maria G. Vilas-Boas, Miguel |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Mehdi, Iouraouine El Falcão, Soraia Boujraf, Saïd Mustapha, Harandou Campos, Maria G. Vilas-Boas, Miguel |
dc.subject.por.fl_str_mv |
Analytical methods Apamin Enzymes Mast cell degranulating peptide Peptides Venomics |
topic |
Analytical methods Apamin Enzymes Mast cell degranulating peptide Peptides Venomics |
description |
The discovery of new drugs has benefited significantly from the development of research in venomics, increasing our understanding of the envenomation processes. It has been previously reported that honeybee venom (HBV) exhibits several pharmacological activities such as anti‑inflammatory, antibacterial, antimutagenic, radioprotective, and anticancer activity and may inclusively act as a complementary treatment for SARS‑CoV‑2. It composition consists mainly on melittin, phospholipase A2, and apamin but other constituents such as hyaluronidase, mast cell degranulating peptide and secapin are also relevant for its bioactivity. However, and because HBV is not officially recognized as a drug, until now, the international community did not establish quality standards for it. To uncover its exact composition, and boost the discovery of HBV‑derived drugs, a significant number of techniques were developed. In this review, a relevant overview of the so far published analytical methods for HBV characterization is organized with the aim to accelerate its future standardization. The literature search was performed within PubMed, Google Scholar, and Science Direct by selecting specific documents and exploring HBV evaluation. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2023-02-08T14:04:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/26816 |
url |
http://hdl.handle.net/10198/26816 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mehdi, Iouraouine El; Falcão, Soraia; Boujraf, Saïd; Mustapha, Harandou; Campos, Maria G.; Vilas-Boas, Miguel (2022). Analytical methods for honeybee venom characterization. Journal of Advanced Pharmaceutical Technology & Research. ISSN 2231-4040. 13:3, p. 154-160 2231-4040 10.4103/japtr.japtr_166_21 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wolters Kluwer |
publisher.none.fl_str_mv |
Wolters Kluwer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799135460838080512 |