Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3

Detalhes bibliográficos
Autor(a) principal: Silva-Costa, Catarina
Data de Publicação: 2021
Outros Autores: Silva, Joana, Prados, Lúcia, Ramirez, Mário, Melo Cristino, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49973
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3Antimicrobial resistanceConjugate vaccineEpidemiologyInvasive diseaseMolecular diagnosticsSerotype© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The introduction of pneumococcal conjugate vaccines PCV7 and PCV13 led to decreases in incidence of pediatric invasive pneumococcal disease (pIPD) and changes in serotype distribution. We evaluated the consequences of higher vaccine uptake after the introduction of PCV13 in the National Immunization Plan (NIP) in 2015. Besides culture and conventional serotyping, the use of molecular methods to detect and serotype pneumococci in both pleural and cerebrospinal fluid samples contributed to 30% of all pIPD (n = 232) in 2015-2018. The most frequently detected serotypes were: 3 (n = 59, 26%), 10A (n = 17, 8%), 8 (n = 16, 7%) and 19A (n = 10, 4%). PCV13 serotypes still accounted for 46% of pIPD cases. Serotypes not included in any currently available conjugate vaccine (NVT) are becoming important causes of pIPD, with the increases in serotypes 8 and 33F being of particular concern given the importance of serotype 8 in adult IPD and the antimicrobial resistance of serotype 33F isolates. This study highlights the importance of using molecular methods in pIPD surveillance since these allowed a better case ascertainment and the identification of serotype 3 as the leading cause of pIPD. Even in a situation of vaccine uptake >95% for 3 years, PCV13 serotypes remain important causes of pIPD.MDPIRepositório da Universidade de LisboaSilva-Costa, CatarinaSilva, JoanaPrados, LúciaRamirez, MárioMelo Cristino, José2021-10-21T13:18:43Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49973engMicroorganisms. 2021 Jul 1;9(7):142810.3390/microorganisms90714282076-2607info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:59Zoai:repositorio.ul.pt:10451/49973Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:30.145171Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3
title Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3
spellingShingle Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3
Silva-Costa, Catarina
Antimicrobial resistance
Conjugate vaccine
Epidemiology
Invasive disease
Molecular diagnostics
Serotype
title_short Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3
title_full Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3
title_fullStr Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3
title_full_unstemmed Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3
title_sort Pediatric invasive Pneumococcal disease three years after PCV13 introduction in the National Immunization Plan—the continued importance of Serotype 3
author Silva-Costa, Catarina
author_facet Silva-Costa, Catarina
Silva, Joana
Prados, Lúcia
Ramirez, Mário
Melo Cristino, José
author_role author
author2 Silva, Joana
Prados, Lúcia
Ramirez, Mário
Melo Cristino, José
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva-Costa, Catarina
Silva, Joana
Prados, Lúcia
Ramirez, Mário
Melo Cristino, José
dc.subject.por.fl_str_mv Antimicrobial resistance
Conjugate vaccine
Epidemiology
Invasive disease
Molecular diagnostics
Serotype
topic Antimicrobial resistance
Conjugate vaccine
Epidemiology
Invasive disease
Molecular diagnostics
Serotype
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-10-21T13:18:43Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49973
url http://hdl.handle.net/10451/49973
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microorganisms. 2021 Jul 1;9(7):1428
10.3390/microorganisms9071428
2076-2607
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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