ADDovenom

Menzies, Stefanie K.; Arinto-Garcia, Raquel; Amorim, Fernanda Gobbi; Cardoso, Iara Aimê; Abada, Camille; Crasset, Thomas; Durbesson, Fabien; Edge, Rebecca J.; El-Kazzi, Priscila; Hall, Sophie; Redureau, Damien; Stenner, Richard; Boldrini-França, Johara; Sun, Huan; Roldão, António; Alves, Paula M.; Harrison, Robert A.; Vincentelli, Renaud; Berger, Imre; Quinton, Loïc; Casewell, Nicholas R.; Schaffitzel, Christiane

ADDovenom

Detalhes bibliográficos
Autor(a) principal:	Menzies, Stefanie K.
Data de Publicação:	2023
Outros Autores:	Arinto-Garcia, Raquel, Amorim, Fernanda Gobbi, Cardoso, Iara Aimê, Abada, Camille, Crasset, Thomas, Durbesson, Fabien, Edge, Rebecca J., El-Kazzi, Priscila, Hall, Sophie, Redureau, Damien, Stenner, Richard, Boldrini-França, Johara, Sun, Huan, Roldão, António, Alves, Paula M., Harrison, Robert A., Vincentelli, Renaud, Berger, Imre, Quinton, Loïc, Casewell, Nicholas R., Schaffitzel, Christiane
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo:	http://hdl.handle.net/10362/165725
Resumo:	Funding Information: This work is supported by a Horizon 2020 FET OPEN grant ‘ADDovenom’ (899670). Publisher Copyright: © 2023 by the authors.

Metadados do item

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network_acronym_str	RCAP
network_name_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str	7160
spelling	ADDovenomThermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite EnvenomingADDomerantivenombiologicssnakebitevenomToxicologyHealth, Toxicology and MutagenesisFunding Information: This work is supported by a Horizon 2020 FET OPEN grant ‘ADDovenom’ (899670). Publisher Copyright: © 2023 by the authors.Snakebite envenoming can be a life-threatening medical emergency that requires prompt medical intervention to neutralise the effects of venom toxins. Each year up to 138,000 people die from snakebites and threefold more victims suffer life-altering disabilities. The current treatment of snakebite relies solely on antivenom—polyclonal antibodies isolated from the plasma of hyperimmunised animals—which is associated with numerous deficiencies. The ADDovenom project seeks to deliver a novel snakebite therapy, through the use of an innovative protein-based scaffold as a next-generation antivenom. The ADDomer is a megadalton-sized, thermostable synthetic nanoparticle derived from the adenovirus penton base protein; it has 60 high-avidity binding sites to neutralise venom toxins. Here, we outline our experimental strategies to achieve this goal using state-of-the-art protein engineering, expression technology and mass spectrometry, as well as in vitro and in vivo venom neutralisation assays. We anticipate that the approaches described here will produce antivenom with unparalleled efficacy, safety and affordability.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNMenzies, Stefanie K.Arinto-Garcia, RaquelAmorim, Fernanda GobbiCardoso, Iara AimêAbada, CamilleCrasset, ThomasDurbesson, FabienEdge, Rebecca J.El-Kazzi, PriscilaHall, SophieRedureau, DamienStenner, RichardBoldrini-França, JoharaSun, HuanRoldão, AntónioAlves, Paula M.Harrison, Robert A.Vincentelli, RenaudBerger, ImreQuinton, LoïcCasewell, Nicholas R.Schaffitzel, Christiane2024-04-02T23:46:55Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/165725eng2072-6651PURE: 83538042https://doi.org/10.3390/toxins15120673info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:20:07Zoai:run.unl.pt:10362/165725Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:20:07Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	ADDovenom Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming
title	ADDovenom
spellingShingle	ADDovenom Menzies, Stefanie K. ADDomer antivenom biologics snakebite venom Toxicology Health, Toxicology and Mutagenesis
title_short	ADDovenom
title_full	ADDovenom
title_fullStr	ADDovenom
title_full_unstemmed	ADDovenom
title_sort	ADDovenom
author	Menzies, Stefanie K.
author_facet	Menzies, Stefanie K. Arinto-Garcia, Raquel Amorim, Fernanda Gobbi Cardoso, Iara Aimê Abada, Camille Crasset, Thomas Durbesson, Fabien Edge, Rebecca J. El-Kazzi, Priscila Hall, Sophie Redureau, Damien Stenner, Richard Boldrini-França, Johara Sun, Huan Roldão, António Alves, Paula M. Harrison, Robert A. Vincentelli, Renaud Berger, Imre Quinton, Loïc Casewell, Nicholas R. Schaffitzel, Christiane
author_role	author
author2	Arinto-Garcia, Raquel Amorim, Fernanda Gobbi Cardoso, Iara Aimê Abada, Camille Crasset, Thomas Durbesson, Fabien Edge, Rebecca J. El-Kazzi, Priscila Hall, Sophie Redureau, Damien Stenner, Richard Boldrini-França, Johara Sun, Huan Roldão, António Alves, Paula M. Harrison, Robert A. Vincentelli, Renaud Berger, Imre Quinton, Loïc Casewell, Nicholas R. Schaffitzel, Christiane
author2_role	author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN
dc.contributor.author.fl_str_mv	Menzies, Stefanie K. Arinto-Garcia, Raquel Amorim, Fernanda Gobbi Cardoso, Iara Aimê Abada, Camille Crasset, Thomas Durbesson, Fabien Edge, Rebecca J. El-Kazzi, Priscila Hall, Sophie Redureau, Damien Stenner, Richard Boldrini-França, Johara Sun, Huan Roldão, António Alves, Paula M. Harrison, Robert A. Vincentelli, Renaud Berger, Imre Quinton, Loïc Casewell, Nicholas R. Schaffitzel, Christiane
dc.subject.por.fl_str_mv	ADDomer antivenom biologics snakebite venom Toxicology Health, Toxicology and Mutagenesis
topic	ADDomer antivenom biologics snakebite venom Toxicology Health, Toxicology and Mutagenesis
description	Funding Information: This work is supported by a Horizon 2020 FET OPEN grant ‘ADDovenom’ (899670). Publisher Copyright: © 2023 by the authors.
publishDate	2023
dc.date.none.fl_str_mv	2023-12 2023-12-01T00:00:00Z 2024-04-02T23:46:55Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10362/165725
url	http://hdl.handle.net/10362/165725
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	2072-6651 PURE: 83538042 https://doi.org/10.3390/toxins15120673
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str	RCAAP
institution	RCAAP
reponame_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv	mluisa.alvim@gmail.com
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ADDovenom

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