Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/69608 |
Resumo: | Fibromyalgia (FM) has been associated to an increased processing of somatosensory stimuli, but its generalization to other sensory modalities is under discussion. To clarify this, we studied auditory event-related potentials (AEPs) to stimuli of different intensity in patients with FM and healthy controls (HCs), considering the effects of attention mechanisms and medication. We performed two experiments: In study 1 (n = 50 FM, 60 HCs), the stimuli were presented randomly within the sequence; in study 2 (n = 28 FM, 30 HCs), they were presented in blocks of the same intensity. We analyzed intensity and group effects on N1-P2 amplitude and, only for the FM group, the effect of medication and the correlation between AEPs and clinical variables. Contrary to the expectation, the patients showed a trend of reduced AEPs to the loudest tones (study 1) or no significant differences with the HCs (study 2). Medication with central effects significantly reduced AEPs, while no significant relationships between the N1-P2 amplitude/intensity function and patients' symptoms were observed. The findings do not provide evidence of augmented auditory processing in FM. Nevertheless, given the observed effect of medication, the role of sensory amplification as an underlying pathophysiological mechanism in fibromyalgia cannot be discarded. |
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Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgiaCiências Sociais::PsicologiaScience & TechnologyFibromyalgia (FM) has been associated to an increased processing of somatosensory stimuli, but its generalization to other sensory modalities is under discussion. To clarify this, we studied auditory event-related potentials (AEPs) to stimuli of different intensity in patients with FM and healthy controls (HCs), considering the effects of attention mechanisms and medication. We performed two experiments: In study 1 (n = 50 FM, 60 HCs), the stimuli were presented randomly within the sequence; in study 2 (n = 28 FM, 30 HCs), they were presented in blocks of the same intensity. We analyzed intensity and group effects on N1-P2 amplitude and, only for the FM group, the effect of medication and the correlation between AEPs and clinical variables. Contrary to the expectation, the patients showed a trend of reduced AEPs to the loudest tones (study 1) or no significant differences with the HCs (study 2). Medication with central effects significantly reduced AEPs, while no significant relationships between the N1-P2 amplitude/intensity function and patients' symptoms were observed. The findings do not provide evidence of augmented auditory processing in FM. Nevertheless, given the observed effect of medication, the role of sensory amplification as an underlying pathophysiological mechanism in fibromyalgia cannot be discarded.Spanish Government (Ministerio de ciencia e Innovación; ref PSI2009-14555 and, Ministerio de Economía y Competitividad; ref PSI2013-45818-R) and from the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e Estruturación de unidades de investigación competitivas do Sistema universitario de Galicia; grant number GPC 2014/047). A.G.V. was supported by a grant from the Portuguese Foundation for Science and Technology within the scope of the Individual Call to Scientific Employment Stimulus 2017. N.S.V. was supported by a grant from Spanish Government (Ministerio de Economía y Competitividad; grant number BES-2017-082684)Nature ResearchUniversidade do MinhoSamartin-Veiga, N.González-Villar, Alberto J.Triñanes, Y.Gómez-Perretta, C.Carrillo-de-la-Peña, M. T.2020-122020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/69608engSamartin-Veiga, N., González-Villar, A. J., Triñanes, Y., et. al. (2020). Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia. Scientific reports, 10(1), 1-122045-23222045-232210.1038/s41598-020-78377-033318554https://www.nature.com/articles/s41598-020-78377-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:23Zoai:repositorium.sdum.uminho.pt:1822/69608Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:17:05.592767Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia |
title |
Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia |
spellingShingle |
Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia Samartin-Veiga, N. Ciências Sociais::Psicologia Science & Technology |
title_short |
Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia |
title_full |
Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia |
title_fullStr |
Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia |
title_full_unstemmed |
Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia |
title_sort |
Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia |
author |
Samartin-Veiga, N. |
author_facet |
Samartin-Veiga, N. González-Villar, Alberto J. Triñanes, Y. Gómez-Perretta, C. Carrillo-de-la-Peña, M. T. |
author_role |
author |
author2 |
González-Villar, Alberto J. Triñanes, Y. Gómez-Perretta, C. Carrillo-de-la-Peña, M. T. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Samartin-Veiga, N. González-Villar, Alberto J. Triñanes, Y. Gómez-Perretta, C. Carrillo-de-la-Peña, M. T. |
dc.subject.por.fl_str_mv |
Ciências Sociais::Psicologia Science & Technology |
topic |
Ciências Sociais::Psicologia Science & Technology |
description |
Fibromyalgia (FM) has been associated to an increased processing of somatosensory stimuli, but its generalization to other sensory modalities is under discussion. To clarify this, we studied auditory event-related potentials (AEPs) to stimuli of different intensity in patients with FM and healthy controls (HCs), considering the effects of attention mechanisms and medication. We performed two experiments: In study 1 (n = 50 FM, 60 HCs), the stimuli were presented randomly within the sequence; in study 2 (n = 28 FM, 30 HCs), they were presented in blocks of the same intensity. We analyzed intensity and group effects on N1-P2 amplitude and, only for the FM group, the effect of medication and the correlation between AEPs and clinical variables. Contrary to the expectation, the patients showed a trend of reduced AEPs to the loudest tones (study 1) or no significant differences with the HCs (study 2). Medication with central effects significantly reduced AEPs, while no significant relationships between the N1-P2 amplitude/intensity function and patients' symptoms were observed. The findings do not provide evidence of augmented auditory processing in FM. Nevertheless, given the observed effect of medication, the role of sensory amplification as an underlying pathophysiological mechanism in fibromyalgia cannot be discarded. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12 2020-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/69608 |
url |
http://hdl.handle.net/1822/69608 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Samartin-Veiga, N., González-Villar, A. J., Triñanes, Y., et. al. (2020). Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia. Scientific reports, 10(1), 1-12 2045-2322 2045-2322 10.1038/s41598-020-78377-0 33318554 https://www.nature.com/articles/s41598-020-78377-0 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Research |
publisher.none.fl_str_mv |
Nature Research |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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