Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease

Detalhes bibliográficos
Autor(a) principal: Sousa, Rute Dinis
Data de Publicação: 2022
Outros Autores: Gouveia, Miguel, Nunes da Silva, Catarina, Maria Rodrigues, Ana, Cardoso, Graça, Antunes, Ana Filipa, Canhão, Helena, de Almeida, José Miguel Caldas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/143631
Resumo: Funding The present work received support from Janssen-Cilag Farmacêutica, Lda, as an Unrestricted Grant. Janssen-Cilag had no role in the execution of the study, including analyses and interpretation of results.
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spelling Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of diseaseburden of diseasecost of illnessdisability-adjusted life years (DALYs) lostmajor depression with suicide risktreatment-resistant depressionSDG 3 - Good Health and Well-beingFunding The present work received support from Janssen-Cilag Farmacêutica, Lda, as an Unrestricted Grant. Janssen-Cilag had no role in the execution of the study, including analyses and interpretation of results.Introduction: Treatment-Resistant Depression (TRD) and Major Depression with Suicide Risk (MDSR) are types of depression with relevant effects on the health of the population and a potentially significant economic impact. This study estimates the burden of disease and the costs of illness attributed to Treatment-Resistant Depression and Major Depression with Suicide Risk in Portugal. Methods: The disease burden for adults was quantified in 2017 using the Disability-Adjusted Life Years (DALYs) lost. Direct costs related to the health care system and indirect costs were estimated for 2017, with indirect costs resulting from the reduction in productivity. Estimates were based on multiple sources of information, including the National Epidemiological Study on Mental Health, the Hospital Morbidity Database, data from the Portuguese National Statistics Institute on population and causes of death, official data on wages, statistics on the pharmaceutical market, and qualified opinions of experts. Results: The estimated prevalence of TRD, MDSR, and both types of depression combined was 79.4 thousand, 52.5 thousand, and 11.3 thousand patients, respectively. The disease burden (DALY) due to the disability generated by TRD alone, MDSR alone, and the joint prevalence was 25.2 thousand, 21 thousand, and 4.5 thousand, respectively, totaling 50.7 thousand DALYs. The disease burden due to premature death by suicide was 15.6 thousand DALYs. The estimated total disease burden was 66.3 thousand DALYs. In 2017, the annual direct costs with TRD and MDSR were estimated at € 30.8 million, with the most important components being medical appointments and medication. The estimated indirect costs were much higher than the direct costs. Adding work productivity losses due to reduced employment, absenteeism, presenteeism, and premature death, a total cost of € 1.1 billion was obtained. Conclusions: Although TRD and MDSR represent relatively small direct costs for the health system, they have a relevant disease burden and extremely substantial productivity costs for the Portuguese economy and society, making TRD and MDSR priority areas for achieving health gains.Comprehensive Health Research Centre (CHRC) - pólo NMSNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Escola Nacional de Saúde Pública (ENSP)RUNSousa, Rute DinisGouveia, MiguelNunes da Silva, CatarinaMaria Rodrigues, AnaCardoso, GraçaAntunes, Ana FilipaCanhão, Helenade Almeida, José Miguel Caldas2022-09-09T22:41:59Z2022-08-112022-08-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143631eng2296-2565PURE: 46241911https://doi.org/10.3389/fpubh.2022.898491info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:22:14Zoai:run.unl.pt:10362/143631Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:03.511737Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease
title Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease
spellingShingle Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease
Sousa, Rute Dinis
burden of disease
cost of illness
disability-adjusted life years (DALYs) lost
major depression with suicide risk
treatment-resistant depression
SDG 3 - Good Health and Well-being
title_short Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease
title_full Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease
title_fullStr Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease
title_full_unstemmed Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease
title_sort Treatment-resistant depression and major depression with suicide risk-The cost of illness and burden of disease
author Sousa, Rute Dinis
author_facet Sousa, Rute Dinis
Gouveia, Miguel
Nunes da Silva, Catarina
Maria Rodrigues, Ana
Cardoso, Graça
Antunes, Ana Filipa
Canhão, Helena
de Almeida, José Miguel Caldas
author_role author
author2 Gouveia, Miguel
Nunes da Silva, Catarina
Maria Rodrigues, Ana
Cardoso, Graça
Antunes, Ana Filipa
Canhão, Helena
de Almeida, José Miguel Caldas
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comprehensive Health Research Centre (CHRC) - pólo NMS
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Sousa, Rute Dinis
Gouveia, Miguel
Nunes da Silva, Catarina
Maria Rodrigues, Ana
Cardoso, Graça
Antunes, Ana Filipa
Canhão, Helena
de Almeida, José Miguel Caldas
dc.subject.por.fl_str_mv burden of disease
cost of illness
disability-adjusted life years (DALYs) lost
major depression with suicide risk
treatment-resistant depression
SDG 3 - Good Health and Well-being
topic burden of disease
cost of illness
disability-adjusted life years (DALYs) lost
major depression with suicide risk
treatment-resistant depression
SDG 3 - Good Health and Well-being
description Funding The present work received support from Janssen-Cilag Farmacêutica, Lda, as an Unrestricted Grant. Janssen-Cilag had no role in the execution of the study, including analyses and interpretation of results.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-09T22:41:59Z
2022-08-11
2022-08-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143631
url http://hdl.handle.net/10362/143631
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-2565
PURE: 46241911
https://doi.org/10.3389/fpubh.2022.898491
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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