Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109731 https://doi.org/10.1155/2013/724706 |
Resumo: | To evaluate the effect of gender and menopause in cardiovascular risk (CVR) in a healthy population based on both classical and nontraditional markers. Methods. 56 men and 68 women (48 pre- and 20 postmenopause) were enrolled in the study. The following markers were analyzed: blood pressure (BP), body mass index (BMI), waist circumference (WC), glucose, total cholesterol (total-c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-c), oxidized-LDL (Ox-LDL), HDL-c and subpopulations, paraoxonase-1 activity, hsCRP, uric acid, tumor necrosis factor alpha (TNF-), adiponectin, vascular endothelial growth factor (VEGF), and intercellular adhesion molecular 1 (ICAM1). Results. Relative to the women, men present significantly increased BMI,WC, BP, glucose, total-c, TGs, LDL-c, Ox-LDL, uric acid, and TNF- and reduced adiponectin and total and large HDL-c. The protective profile of women is lost after menopause with a significantly increased BMI, WC, BP, glucose, LDL-c, Ox- LDL, hsCRP, and VEGF and decreased total and large HDL-c. Significant correlations were found in women population and in postmenopausal women between Ox-LDL and total, large, and small HDL-c and between TNF- and total, large, and small HDLc, LDL-c, and Ox-LDL. Conclusions. Men present higher CVR than women who lost protection after menopause, evidenced by nontraditional markers, including Ox-LDL and HDL subpopulations. |
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Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulationsAdultAgedAryldialkylphosphataseBiomarkersCardiovascular DiseasesFemaleHumansLipoproteins, HDLLipoproteins, LDLMaleMiddle AgedPostmenopauseRisk FactorsYoung AdultTo evaluate the effect of gender and menopause in cardiovascular risk (CVR) in a healthy population based on both classical and nontraditional markers. Methods. 56 men and 68 women (48 pre- and 20 postmenopause) were enrolled in the study. The following markers were analyzed: blood pressure (BP), body mass index (BMI), waist circumference (WC), glucose, total cholesterol (total-c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-c), oxidized-LDL (Ox-LDL), HDL-c and subpopulations, paraoxonase-1 activity, hsCRP, uric acid, tumor necrosis factor alpha (TNF-), adiponectin, vascular endothelial growth factor (VEGF), and intercellular adhesion molecular 1 (ICAM1). Results. Relative to the women, men present significantly increased BMI,WC, BP, glucose, total-c, TGs, LDL-c, Ox-LDL, uric acid, and TNF- and reduced adiponectin and total and large HDL-c. The protective profile of women is lost after menopause with a significantly increased BMI, WC, BP, glucose, LDL-c, Ox- LDL, hsCRP, and VEGF and decreased total and large HDL-c. Significant correlations were found in women population and in postmenopausal women between Ox-LDL and total, large, and small HDL-c and between TNF- and total, large, and small HDLc, LDL-c, and Ox-LDL. Conclusions. Men present higher CVR than women who lost protection after menopause, evidenced by nontraditional markers, including Ox-LDL and HDL subpopulations.Hindawi2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109731http://hdl.handle.net/10316/109731https://doi.org/10.1155/2013/724706eng0278-02401875-8630Mascarenhas-Melo, FilipaSereno, JoséLemos, Edite Teixeira deRibeiro, SandraRocha-Pereira, PetronilaCotterill, EthanTeixeira, FredericoReis, Flávioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-24T11:54:14Zoai:estudogeral.uc.pt:10316/109731Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:53.086563Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations |
title |
Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations |
spellingShingle |
Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations Mascarenhas-Melo, Filipa Adult Aged Aryldialkylphosphatase Biomarkers Cardiovascular Diseases Female Humans Lipoproteins, HDL Lipoproteins, LDL Male Middle Aged Postmenopause Risk Factors Young Adult |
title_short |
Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations |
title_full |
Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations |
title_fullStr |
Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations |
title_full_unstemmed |
Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations |
title_sort |
Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations |
author |
Mascarenhas-Melo, Filipa |
author_facet |
Mascarenhas-Melo, Filipa Sereno, José Lemos, Edite Teixeira de Ribeiro, Sandra Rocha-Pereira, Petronila Cotterill, Ethan Teixeira, Frederico Reis, Flávio |
author_role |
author |
author2 |
Sereno, José Lemos, Edite Teixeira de Ribeiro, Sandra Rocha-Pereira, Petronila Cotterill, Ethan Teixeira, Frederico Reis, Flávio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Mascarenhas-Melo, Filipa Sereno, José Lemos, Edite Teixeira de Ribeiro, Sandra Rocha-Pereira, Petronila Cotterill, Ethan Teixeira, Frederico Reis, Flávio |
dc.subject.por.fl_str_mv |
Adult Aged Aryldialkylphosphatase Biomarkers Cardiovascular Diseases Female Humans Lipoproteins, HDL Lipoproteins, LDL Male Middle Aged Postmenopause Risk Factors Young Adult |
topic |
Adult Aged Aryldialkylphosphatase Biomarkers Cardiovascular Diseases Female Humans Lipoproteins, HDL Lipoproteins, LDL Male Middle Aged Postmenopause Risk Factors Young Adult |
description |
To evaluate the effect of gender and menopause in cardiovascular risk (CVR) in a healthy population based on both classical and nontraditional markers. Methods. 56 men and 68 women (48 pre- and 20 postmenopause) were enrolled in the study. The following markers were analyzed: blood pressure (BP), body mass index (BMI), waist circumference (WC), glucose, total cholesterol (total-c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-c), oxidized-LDL (Ox-LDL), HDL-c and subpopulations, paraoxonase-1 activity, hsCRP, uric acid, tumor necrosis factor alpha (TNF-), adiponectin, vascular endothelial growth factor (VEGF), and intercellular adhesion molecular 1 (ICAM1). Results. Relative to the women, men present significantly increased BMI,WC, BP, glucose, total-c, TGs, LDL-c, Ox-LDL, uric acid, and TNF- and reduced adiponectin and total and large HDL-c. The protective profile of women is lost after menopause with a significantly increased BMI, WC, BP, glucose, LDL-c, Ox- LDL, hsCRP, and VEGF and decreased total and large HDL-c. Significant correlations were found in women population and in postmenopausal women between Ox-LDL and total, large, and small HDL-c and between TNF- and total, large, and small HDLc, LDL-c, and Ox-LDL. Conclusions. Men present higher CVR than women who lost protection after menopause, evidenced by nontraditional markers, including Ox-LDL and HDL subpopulations. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109731 http://hdl.handle.net/10316/109731 https://doi.org/10.1155/2013/724706 |
url |
http://hdl.handle.net/10316/109731 https://doi.org/10.1155/2013/724706 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0278-0240 1875-8630 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Hindawi |
publisher.none.fl_str_mv |
Hindawi |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134140295020544 |