Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/69498 |
Resumo: | This work reports on magnetoelectric biomaterials suitable for effective proliferation and differentiation of myoblast in a biomimetic microenvironment providing the electromechanical stimuli associated with this tissue in the human body. Magnetoelectric films are obtained by solvent casting through the combination of a piezoelectric polymer, poly(vinylidene fluoride-trifluoro-ethylene), and magnetostrictive particles (CoFe2O4). The nonpoled and poled (with negative and positive surface charge) magnetoelectric composites are used to investigate their influence on C2C12 myoblast adhesion, proliferation, and differentiation. It is demonstrated that the proliferation and differentiation of the cells are enhanced by the application of mechanical and/or electrical stimulation, with higher values of maturation index under mechanoelectrical stimuli. These results show that magnetoelectric cell stimulation is a full potential approach for skeletal muscle tissue engineering applications |
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Magnetically activated electroactive microenvironments for skeletal muscle tissue regenerationMagnetoelectric biomaterialsMuscle tissue engineeringMechanoelectrical stimuliMyotubes bioreactorsbioreactorsmyotubesCiências Médicas::Biotecnologia MédicaEngenharia e Tecnologia::Engenharia MédicaScience & TechnologyThis work reports on magnetoelectric biomaterials suitable for effective proliferation and differentiation of myoblast in a biomimetic microenvironment providing the electromechanical stimuli associated with this tissue in the human body. Magnetoelectric films are obtained by solvent casting through the combination of a piezoelectric polymer, poly(vinylidene fluoride-trifluoro-ethylene), and magnetostrictive particles (CoFe2O4). The nonpoled and poled (with negative and positive surface charge) magnetoelectric composites are used to investigate their influence on C2C12 myoblast adhesion, proliferation, and differentiation. It is demonstrated that the proliferation and differentiation of the cells are enhanced by the application of mechanical and/or electrical stimulation, with higher values of maturation index under mechanoelectrical stimuli. These results show that magnetoelectric cell stimulation is a full potential approach for skeletal muscle tissue engineering applicationsPortuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2020, UID/BIA/04050/2020, UID/BIO/04469/2020 and projects PTDC/BTM-MAT/28237/2017 and PTDC/EMDEMD/28159/2017. The authors also thank the FCT for the SFRH/BD/111478/2015 (S.R.) grant. The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry and Education Department under the ELKARTEK, HAZITEK and PIBA (PIBA-2018-06)ACS PublicationsUniversidade do MinhoRibeiro, Sylvie OliveiraRibeiro, C.Carvalho, E. O.Tubio, C. R.Castro, N.Rodrigues, Nelson Ricardo PereiraCorreia, V.Gomes, A. C.Lanceros-Méndez, S.20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/69498engRibeiro, S., Ribeiro, C., Carvalho, E. O., Tubio, C. R., et. al.(2020). Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration. ACS Applied Bio Materials2576-64222576-642210.1021/acsabm.0c0031535025425https://pubs.acs.org/doi/abs/10.1021/acsabm.0c00315info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:24:33Zoai:repositorium.sdum.uminho.pt:1822/69498Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:18:35.353071Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration |
title |
Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration |
spellingShingle |
Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration Ribeiro, Sylvie Oliveira Magnetoelectric biomaterials Muscle tissue engineering Mechanoelectrical stimuli Myotubes bioreactors bioreactors myotubes Ciências Médicas::Biotecnologia Médica Engenharia e Tecnologia::Engenharia Médica Science & Technology |
title_short |
Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration |
title_full |
Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration |
title_fullStr |
Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration |
title_full_unstemmed |
Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration |
title_sort |
Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration |
author |
Ribeiro, Sylvie Oliveira |
author_facet |
Ribeiro, Sylvie Oliveira Ribeiro, C. Carvalho, E. O. Tubio, C. R. Castro, N. Rodrigues, Nelson Ricardo Pereira Correia, V. Gomes, A. C. Lanceros-Méndez, S. |
author_role |
author |
author2 |
Ribeiro, C. Carvalho, E. O. Tubio, C. R. Castro, N. Rodrigues, Nelson Ricardo Pereira Correia, V. Gomes, A. C. Lanceros-Méndez, S. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ribeiro, Sylvie Oliveira Ribeiro, C. Carvalho, E. O. Tubio, C. R. Castro, N. Rodrigues, Nelson Ricardo Pereira Correia, V. Gomes, A. C. Lanceros-Méndez, S. |
dc.subject.por.fl_str_mv |
Magnetoelectric biomaterials Muscle tissue engineering Mechanoelectrical stimuli Myotubes bioreactors bioreactors myotubes Ciências Médicas::Biotecnologia Médica Engenharia e Tecnologia::Engenharia Médica Science & Technology |
topic |
Magnetoelectric biomaterials Muscle tissue engineering Mechanoelectrical stimuli Myotubes bioreactors bioreactors myotubes Ciências Médicas::Biotecnologia Médica Engenharia e Tecnologia::Engenharia Médica Science & Technology |
description |
This work reports on magnetoelectric biomaterials suitable for effective proliferation and differentiation of myoblast in a biomimetic microenvironment providing the electromechanical stimuli associated with this tissue in the human body. Magnetoelectric films are obtained by solvent casting through the combination of a piezoelectric polymer, poly(vinylidene fluoride-trifluoro-ethylene), and magnetostrictive particles (CoFe2O4). The nonpoled and poled (with negative and positive surface charge) magnetoelectric composites are used to investigate their influence on C2C12 myoblast adhesion, proliferation, and differentiation. It is demonstrated that the proliferation and differentiation of the cells are enhanced by the application of mechanical and/or electrical stimulation, with higher values of maturation index under mechanoelectrical stimuli. These results show that magnetoelectric cell stimulation is a full potential approach for skeletal muscle tissue engineering applications |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/69498 |
url |
https://hdl.handle.net/1822/69498 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ribeiro, S., Ribeiro, C., Carvalho, E. O., Tubio, C. R., et. al.(2020). Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration. ACS Applied Bio Materials 2576-6422 2576-6422 10.1021/acsabm.0c00315 35025425 https://pubs.acs.org/doi/abs/10.1021/acsabm.0c00315 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
ACS Publications |
publisher.none.fl_str_mv |
ACS Publications |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132641435320320 |