Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/104030 https://doi.org/10.1111/eci.13515 |
Resumo: | 'Special issue - In Utero and Early Life Programming of Aging and Disease'. Skeletal muscle (SM) adaptations to physical exercise (PE) have been extensively studied due, not only to the relevance of its in situ plasticity, but also to the SM endocrine-like effects in noncontractile tissues, such as brain, liver or adipocytes. Regular PE has been considered a pleiotropic nonpharmacological strategy to prevent and counteract the deleterious consequences of several metabolic, cardiovascular, oncological and neurodegenerative disorders. Additionally, PE performed by parents seems to have a direct impact in the offspring through the transgenerational programming of different tissues, such as SM. In fact, SM offspring programming mechanisms seems to be orchestrated, at least in part, by epigenetic machinery conditioning transcriptional or post-transcriptional processes. Ultimately, PE performed in the early in life is also a critical window of opportunity to positively modulate the juvenile and adult phenotype. Parental PE has a positive impact in several health-related offspring outcomes, such as SM metabolism, differentiation, morphology and ultimately in offspring exercise volition and endurance. Also, early-life PE counteracts conceptional-related adverse effects and induces long-lasting healthy benefits throughout adulthood. Additionally, epigenetics mechanisms seem to play a key role in the PE-induced SM adaptations. Despite the undoubtedly positive role of parental and early-life PE on SM phenotype, a strong research effort is still needed to better understand the mechanisms that positively regulate PE-induced SM programming. |
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Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exerciseearly-life exercise; epigenetics; maternal exercise; offspring; paternal exerciseEpigenesis, GeneticExerciseFemaleGrowthHumansMuscle, SkeletalPregnancy'Special issue - In Utero and Early Life Programming of Aging and Disease'. Skeletal muscle (SM) adaptations to physical exercise (PE) have been extensively studied due, not only to the relevance of its in situ plasticity, but also to the SM endocrine-like effects in noncontractile tissues, such as brain, liver or adipocytes. Regular PE has been considered a pleiotropic nonpharmacological strategy to prevent and counteract the deleterious consequences of several metabolic, cardiovascular, oncological and neurodegenerative disorders. Additionally, PE performed by parents seems to have a direct impact in the offspring through the transgenerational programming of different tissues, such as SM. In fact, SM offspring programming mechanisms seems to be orchestrated, at least in part, by epigenetic machinery conditioning transcriptional or post-transcriptional processes. Ultimately, PE performed in the early in life is also a critical window of opportunity to positively modulate the juvenile and adult phenotype. Parental PE has a positive impact in several health-related offspring outcomes, such as SM metabolism, differentiation, morphology and ultimately in offspring exercise volition and endurance. Also, early-life PE counteracts conceptional-related adverse effects and induces long-lasting healthy benefits throughout adulthood. Additionally, epigenetics mechanisms seem to play a key role in the PE-induced SM adaptations. Despite the undoubtedly positive role of parental and early-life PE on SM phenotype, a strong research effort is still needed to better understand the mechanisms that positively regulate PE-induced SM programming.2021-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/104030http://hdl.handle.net/10316/104030https://doi.org/10.1111/eci.13515por0014-29721365-2362https://onlinelibrary.wiley.com/doi/10.1111/eci.13515Beleza, JorgeStevanović-Silva, JelenaCoxito, PedroCosta, Rui CarlosAscensão, AntónioTorrella, Joan RamonMagalhães, Joséinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-16T21:38:52Zoai:estudogeral.uc.pt:10316/104030Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:45.505896Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise |
title |
Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise |
spellingShingle |
Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise Beleza, Jorge early-life exercise; epigenetics; maternal exercise; offspring; paternal exercise Epigenesis, Genetic Exercise Female Growth Humans Muscle, Skeletal Pregnancy |
title_short |
Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise |
title_full |
Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise |
title_fullStr |
Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise |
title_full_unstemmed |
Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise |
title_sort |
Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise |
author |
Beleza, Jorge |
author_facet |
Beleza, Jorge Stevanović-Silva, Jelena Coxito, Pedro Costa, Rui Carlos Ascensão, António Torrella, Joan Ramon Magalhães, José |
author_role |
author |
author2 |
Stevanović-Silva, Jelena Coxito, Pedro Costa, Rui Carlos Ascensão, António Torrella, Joan Ramon Magalhães, José |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Beleza, Jorge Stevanović-Silva, Jelena Coxito, Pedro Costa, Rui Carlos Ascensão, António Torrella, Joan Ramon Magalhães, José |
dc.subject.por.fl_str_mv |
early-life exercise; epigenetics; maternal exercise; offspring; paternal exercise Epigenesis, Genetic Exercise Female Growth Humans Muscle, Skeletal Pregnancy |
topic |
early-life exercise; epigenetics; maternal exercise; offspring; paternal exercise Epigenesis, Genetic Exercise Female Growth Humans Muscle, Skeletal Pregnancy |
description |
'Special issue - In Utero and Early Life Programming of Aging and Disease'. Skeletal muscle (SM) adaptations to physical exercise (PE) have been extensively studied due, not only to the relevance of its in situ plasticity, but also to the SM endocrine-like effects in noncontractile tissues, such as brain, liver or adipocytes. Regular PE has been considered a pleiotropic nonpharmacological strategy to prevent and counteract the deleterious consequences of several metabolic, cardiovascular, oncological and neurodegenerative disorders. Additionally, PE performed by parents seems to have a direct impact in the offspring through the transgenerational programming of different tissues, such as SM. In fact, SM offspring programming mechanisms seems to be orchestrated, at least in part, by epigenetic machinery conditioning transcriptional or post-transcriptional processes. Ultimately, PE performed in the early in life is also a critical window of opportunity to positively modulate the juvenile and adult phenotype. Parental PE has a positive impact in several health-related offspring outcomes, such as SM metabolism, differentiation, morphology and ultimately in offspring exercise volition and endurance. Also, early-life PE counteracts conceptional-related adverse effects and induces long-lasting healthy benefits throughout adulthood. Additionally, epigenetics mechanisms seem to play a key role in the PE-induced SM adaptations. Despite the undoubtedly positive role of parental and early-life PE on SM phenotype, a strong research effort is still needed to better understand the mechanisms that positively regulate PE-induced SM programming. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/104030 http://hdl.handle.net/10316/104030 https://doi.org/10.1111/eci.13515 |
url |
http://hdl.handle.net/10316/104030 https://doi.org/10.1111/eci.13515 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
0014-2972 1365-2362 https://onlinelibrary.wiley.com/doi/10.1111/eci.13515 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134099739246592 |