Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004 |
Resumo: | Background: Introduction: Raynaud's phenomenon (RP) is a well-defined clinical syndrome. Systemic sclerosis (SSc) is the most frequent associated disease to RP (96%). The aim of this study was to assess the differences between primary RP (PRP) and secondary RP (SRP) regarding macrovascular disease parameters, endothelial dysfunction and angiogenesis biomarkers. Materials and methods: Flow-mediated dilatation (FMD), endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA) vascular endothelial growth factor (VEGF), endoglin and endostatin were analyzed in a cohort study of 32 PRP patients and 77 SRP all with SSc. 38 of the SRP SSc-associated patients had severe digital ulcer (DU). Results: Patients with PRP had significantly longer history of RP compared to SRP SSc-sssociated patients (p = 0.028). FMD was significantly lower in SRP patients 10.85 ± 11.0% (p < 0.001), more evidenced in SRP SSc-associated DU patients 5.34 ± 7.49 (p < 0.001). ET-1 plasma levels were significantly increased in both PRP 7.53 (0.16--11.73) and SRP patients 11.85 (7.42--17.23) (p < 0.001). Significant increased serum levels of ADMA 0.52 (0.45--0.63) µmol/L (p < 0.001) and endoglin 3.01 (1.46--7.02) mg/ml (p < 0.001) were found in the SRP SSc-associated group with DU. VEGF was significantly decreased in the DU group 245.06 (158.68--347.33) pg/ml compared to PRP 438.50 (269.26-854.00) pg/ml and SRP naïve-DU patients 290 (166.71--361.78) pg/ml patients (p < 0.001). No significant differences were found between groups regarding endostatin (p = 0.118). Comparing PRP and SRP SSc-associated patients without DU no statistically significant difference regarding FMD, ET-1, ADMA, VEGF, plasma levels were observed. Conclusion: Overproduction of ET-1 and VEGF is present in PRP patients. Macrovascular disease and an impaired response to shear stress are more characteristic of SRP with a grater expression in patients with peripheral ischemic lesions. |
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7160 |
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Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkersRaynaudEndothelial dysfunctionAngiogenesisBiomarkersDigital ulcersBackground: Introduction: Raynaud's phenomenon (RP) is a well-defined clinical syndrome. Systemic sclerosis (SSc) is the most frequent associated disease to RP (96%). The aim of this study was to assess the differences between primary RP (PRP) and secondary RP (SRP) regarding macrovascular disease parameters, endothelial dysfunction and angiogenesis biomarkers. Materials and methods: Flow-mediated dilatation (FMD), endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA) vascular endothelial growth factor (VEGF), endoglin and endostatin were analyzed in a cohort study of 32 PRP patients and 77 SRP all with SSc. 38 of the SRP SSc-associated patients had severe digital ulcer (DU). Results: Patients with PRP had significantly longer history of RP compared to SRP SSc-sssociated patients (p = 0.028). FMD was significantly lower in SRP patients 10.85 ± 11.0% (p < 0.001), more evidenced in SRP SSc-associated DU patients 5.34 ± 7.49 (p < 0.001). ET-1 plasma levels were significantly increased in both PRP 7.53 (0.16--11.73) and SRP patients 11.85 (7.42--17.23) (p < 0.001). Significant increased serum levels of ADMA 0.52 (0.45--0.63) µmol/L (p < 0.001) and endoglin 3.01 (1.46--7.02) mg/ml (p < 0.001) were found in the SRP SSc-associated group with DU. VEGF was significantly decreased in the DU group 245.06 (158.68--347.33) pg/ml compared to PRP 438.50 (269.26-854.00) pg/ml and SRP naïve-DU patients 290 (166.71--361.78) pg/ml patients (p < 0.001). No significant differences were found between groups regarding endostatin (p = 0.118). Comparing PRP and SRP SSc-associated patients without DU no statistically significant difference regarding FMD, ET-1, ADMA, VEGF, plasma levels were observed. Conclusion: Overproduction of ET-1 and VEGF is present in PRP patients. Macrovascular disease and an impaired response to shear stress are more characteristic of SRP with a grater expression in patients with peripheral ischemic lesions.Sociedade Portuguesa de Angiologia e Cirurgia Vascular2016-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004Angiologia e Cirurgia Vascular v.12 n.2 2016reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004Silva,IvoneTeixeira,AndreiaOliveira,JoséAlmeida,RuiVasconcelos,Carlosinfo:eu-repo/semantics/openAccess2024-02-06T17:22:43Zoai:scielo:S1646-706X2016000200004Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:29:18.137250Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers |
title |
Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers |
spellingShingle |
Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers Silva,Ivone Raynaud Endothelial dysfunction Angiogenesis Biomarkers Digital ulcers |
title_short |
Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers |
title_full |
Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers |
title_fullStr |
Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers |
title_full_unstemmed |
Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers |
title_sort |
Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers |
author |
Silva,Ivone |
author_facet |
Silva,Ivone Teixeira,Andreia Oliveira,José Almeida,Rui Vasconcelos,Carlos |
author_role |
author |
author2 |
Teixeira,Andreia Oliveira,José Almeida,Rui Vasconcelos,Carlos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva,Ivone Teixeira,Andreia Oliveira,José Almeida,Rui Vasconcelos,Carlos |
dc.subject.por.fl_str_mv |
Raynaud Endothelial dysfunction Angiogenesis Biomarkers Digital ulcers |
topic |
Raynaud Endothelial dysfunction Angiogenesis Biomarkers Digital ulcers |
description |
Background: Introduction: Raynaud's phenomenon (RP) is a well-defined clinical syndrome. Systemic sclerosis (SSc) is the most frequent associated disease to RP (96%). The aim of this study was to assess the differences between primary RP (PRP) and secondary RP (SRP) regarding macrovascular disease parameters, endothelial dysfunction and angiogenesis biomarkers. Materials and methods: Flow-mediated dilatation (FMD), endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA) vascular endothelial growth factor (VEGF), endoglin and endostatin were analyzed in a cohort study of 32 PRP patients and 77 SRP all with SSc. 38 of the SRP SSc-associated patients had severe digital ulcer (DU). Results: Patients with PRP had significantly longer history of RP compared to SRP SSc-sssociated patients (p = 0.028). FMD was significantly lower in SRP patients 10.85 ± 11.0% (p < 0.001), more evidenced in SRP SSc-associated DU patients 5.34 ± 7.49 (p < 0.001). ET-1 plasma levels were significantly increased in both PRP 7.53 (0.16--11.73) and SRP patients 11.85 (7.42--17.23) (p < 0.001). Significant increased serum levels of ADMA 0.52 (0.45--0.63) µmol/L (p < 0.001) and endoglin 3.01 (1.46--7.02) mg/ml (p < 0.001) were found in the SRP SSc-associated group with DU. VEGF was significantly decreased in the DU group 245.06 (158.68--347.33) pg/ml compared to PRP 438.50 (269.26-854.00) pg/ml and SRP naïve-DU patients 290 (166.71--361.78) pg/ml patients (p < 0.001). No significant differences were found between groups regarding endostatin (p = 0.118). Comparing PRP and SRP SSc-associated patients without DU no statistically significant difference regarding FMD, ET-1, ADMA, VEGF, plasma levels were observed. Conclusion: Overproduction of ET-1 and VEGF is present in PRP patients. Macrovascular disease and an impaired response to shear stress are more characteristic of SRP with a grater expression in patients with peripheral ischemic lesions. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Angiologia e Cirurgia Vascular |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Angiologia e Cirurgia Vascular |
dc.source.none.fl_str_mv |
Angiologia e Cirurgia Vascular v.12 n.2 2016 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137360437313536 |