Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers

Detalhes bibliográficos
Autor(a) principal: Silva,Ivone
Data de Publicação: 2016
Outros Autores: Teixeira,Andreia, Oliveira,José, Almeida,Rui, Vasconcelos,Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004
Resumo: Background: Introduction: Raynaud's phenomenon (RP) is a well-defined clinical syndrome. Systemic sclerosis (SSc) is the most frequent associated disease to RP (96%). The aim of this study was to assess the differences between primary RP (PRP) and secondary RP (SRP) regarding macrovascular disease parameters, endothelial dysfunction and angiogenesis biomarkers. Materials and methods: Flow-mediated dilatation (FMD), endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA) vascular endothelial growth factor (VEGF), endoglin and endostatin were analyzed in a cohort study of 32 PRP patients and 77 SRP all with SSc. 38 of the SRP SSc-associated patients had severe digital ulcer (DU). Results: Patients with PRP had significantly longer history of RP compared to SRP SSc-sssociated patients (p = 0.028). FMD was significantly lower in SRP patients 10.85 ± 11.0% (p < 0.001), more evidenced in SRP SSc-associated DU patients 5.34 ± 7.49 (p < 0.001). ET-1 plasma levels were significantly increased in both PRP 7.53 (0.16--11.73) and SRP patients 11.85 (7.42--17.23) (p < 0.001). Significant increased serum levels of ADMA 0.52 (0.45--0.63) µmol/L (p < 0.001) and endoglin 3.01 (1.46--7.02) mg/ml (p < 0.001) were found in the SRP SSc-associated group with DU. VEGF was significantly decreased in the DU group 245.06 (158.68--347.33) pg/ml compared to PRP 438.50 (269.26-854.00) pg/ml and SRP naïve-DU patients 290 (166.71--361.78) pg/ml patients (p < 0.001). No significant differences were found between groups regarding endostatin (p = 0.118). Comparing PRP and SRP SSc-associated patients without DU no statistically significant difference regarding FMD, ET-1, ADMA, VEGF, plasma levels were observed. Conclusion: Overproduction of ET-1 and VEGF is present in PRP patients. Macrovascular disease and an impaired response to shear stress are more characteristic of SRP with a grater expression in patients with peripheral ischemic lesions.
id RCAP_ff5f71f55eba52b35d17193a8e6fbf3a
oai_identifier_str oai:scielo:S1646-706X2016000200004
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkersRaynaudEndothelial dysfunctionAngiogenesisBiomarkersDigital ulcersBackground: Introduction: Raynaud's phenomenon (RP) is a well-defined clinical syndrome. Systemic sclerosis (SSc) is the most frequent associated disease to RP (96%). The aim of this study was to assess the differences between primary RP (PRP) and secondary RP (SRP) regarding macrovascular disease parameters, endothelial dysfunction and angiogenesis biomarkers. Materials and methods: Flow-mediated dilatation (FMD), endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA) vascular endothelial growth factor (VEGF), endoglin and endostatin were analyzed in a cohort study of 32 PRP patients and 77 SRP all with SSc. 38 of the SRP SSc-associated patients had severe digital ulcer (DU). Results: Patients with PRP had significantly longer history of RP compared to SRP SSc-sssociated patients (p = 0.028). FMD was significantly lower in SRP patients 10.85 ± 11.0% (p < 0.001), more evidenced in SRP SSc-associated DU patients 5.34 ± 7.49 (p < 0.001). ET-1 plasma levels were significantly increased in both PRP 7.53 (0.16--11.73) and SRP patients 11.85 (7.42--17.23) (p < 0.001). Significant increased serum levels of ADMA 0.52 (0.45--0.63) µmol/L (p < 0.001) and endoglin 3.01 (1.46--7.02) mg/ml (p < 0.001) were found in the SRP SSc-associated group with DU. VEGF was significantly decreased in the DU group 245.06 (158.68--347.33) pg/ml compared to PRP 438.50 (269.26-854.00) pg/ml and SRP naïve-DU patients 290 (166.71--361.78) pg/ml patients (p < 0.001). No significant differences were found between groups regarding endostatin (p = 0.118). Comparing PRP and SRP SSc-associated patients without DU no statistically significant difference regarding FMD, ET-1, ADMA, VEGF, plasma levels were observed. Conclusion: Overproduction of ET-1 and VEGF is present in PRP patients. Macrovascular disease and an impaired response to shear stress are more characteristic of SRP with a grater expression in patients with peripheral ischemic lesions.Sociedade Portuguesa de Angiologia e Cirurgia Vascular2016-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004Angiologia e Cirurgia Vascular v.12 n.2 2016reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004Silva,IvoneTeixeira,AndreiaOliveira,JoséAlmeida,RuiVasconcelos,Carlosinfo:eu-repo/semantics/openAccess2024-02-06T17:22:43Zoai:scielo:S1646-706X2016000200004Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:29:18.137250Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
title Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
spellingShingle Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
Silva,Ivone
Raynaud
Endothelial dysfunction
Angiogenesis
Biomarkers
Digital ulcers
title_short Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
title_full Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
title_fullStr Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
title_full_unstemmed Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
title_sort Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers
author Silva,Ivone
author_facet Silva,Ivone
Teixeira,Andreia
Oliveira,José
Almeida,Rui
Vasconcelos,Carlos
author_role author
author2 Teixeira,Andreia
Oliveira,José
Almeida,Rui
Vasconcelos,Carlos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva,Ivone
Teixeira,Andreia
Oliveira,José
Almeida,Rui
Vasconcelos,Carlos
dc.subject.por.fl_str_mv Raynaud
Endothelial dysfunction
Angiogenesis
Biomarkers
Digital ulcers
topic Raynaud
Endothelial dysfunction
Angiogenesis
Biomarkers
Digital ulcers
description Background: Introduction: Raynaud's phenomenon (RP) is a well-defined clinical syndrome. Systemic sclerosis (SSc) is the most frequent associated disease to RP (96%). The aim of this study was to assess the differences between primary RP (PRP) and secondary RP (SRP) regarding macrovascular disease parameters, endothelial dysfunction and angiogenesis biomarkers. Materials and methods: Flow-mediated dilatation (FMD), endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA) vascular endothelial growth factor (VEGF), endoglin and endostatin were analyzed in a cohort study of 32 PRP patients and 77 SRP all with SSc. 38 of the SRP SSc-associated patients had severe digital ulcer (DU). Results: Patients with PRP had significantly longer history of RP compared to SRP SSc-sssociated patients (p = 0.028). FMD was significantly lower in SRP patients 10.85 ± 11.0% (p < 0.001), more evidenced in SRP SSc-associated DU patients 5.34 ± 7.49 (p < 0.001). ET-1 plasma levels were significantly increased in both PRP 7.53 (0.16--11.73) and SRP patients 11.85 (7.42--17.23) (p < 0.001). Significant increased serum levels of ADMA 0.52 (0.45--0.63) µmol/L (p < 0.001) and endoglin 3.01 (1.46--7.02) mg/ml (p < 0.001) were found in the SRP SSc-associated group with DU. VEGF was significantly decreased in the DU group 245.06 (158.68--347.33) pg/ml compared to PRP 438.50 (269.26-854.00) pg/ml and SRP naïve-DU patients 290 (166.71--361.78) pg/ml patients (p < 0.001). No significant differences were found between groups regarding endostatin (p = 0.118). Comparing PRP and SRP SSc-associated patients without DU no statistically significant difference regarding FMD, ET-1, ADMA, VEGF, plasma levels were observed. Conclusion: Overproduction of ET-1 and VEGF is present in PRP patients. Macrovascular disease and an impaired response to shear stress are more characteristic of SRP with a grater expression in patients with peripheral ischemic lesions.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-706X2016000200004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
dc.source.none.fl_str_mv Angiologia e Cirurgia Vascular v.12 n.2 2016
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137360437313536