Severe Thrombocitopenia Induced by Fenofibrate

• Autor(a) principal: Clara, Ana
• Data de Publicação: 2020
• Outros Autores: Martins, Tiago, Martins, Alexandra, Baptista, Ana, Lázaro, Mário
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11354
• topic: Fenofibrate/adverse effects; Purpura; Thrombocytopenic; Idiopathic/chemically induced; Fenofibrato/efeitos adversos; Púrpura Trombocitopénica Idiopática/induzida quimicamente

Drug-induced thrombocytopenia is a common entity in clinical practice. However, having in consideration the severity of the case, it becomes imperative to distinguish non-immune thrombocytopenia from the po-tentially life-threatening immune-mediated forms. The authors report a rare clinical case of a 79-year-old man presenting with purpuric rash and gingival hemorrhage while on fenofibrate treatment (sixth day). The evolu-tion was favorable after drug removal and corticosteroid administration. Drug-associated thrombocytopenia is reported by manufacturers as an extremely rare event. This is the second case report of immune throm-bocytopenia to fenofibrate. The first event was reported for publication in 2015.