Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/48046 |
Resumo: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancerCancerPeriprostatic fatPhysical activitySkeletal muscleTumor microenvironmentVisceral adiposity© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo- and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.MDPIRepositório da Universidade de LisboaRocha-Rodrigues, SílviaMatos, AndreiaAfonso, JoséMendes-Ferreira, MiguelAbade, EduardoTeixeira, EduardoSilva, BrunoMurawska-Ciałowicz, EugeniaOliveira, Maria JoséRibeiro, Ricardo2021-05-20T14:28:18Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48046engInt J Mol Sci. 2021 Apr 25;22(9):4469.1661-659610.3390/ijms220944691422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-14T15:35:21ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer |
title |
Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer |
spellingShingle |
Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer Rocha-Rodrigues, Sílvia Cancer Periprostatic fat Physical activity Skeletal muscle Tumor microenvironment Visceral adiposity |
title_short |
Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer |
title_full |
Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer |
title_fullStr |
Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer |
title_full_unstemmed |
Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer |
title_sort |
Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer |
author |
Rocha-Rodrigues, Sílvia |
author_facet |
Rocha-Rodrigues, Sílvia Matos, Andreia Afonso, José Mendes-Ferreira, Miguel Abade, Eduardo Teixeira, Eduardo Silva, Bruno Murawska-Ciałowicz, Eugenia Oliveira, Maria José Ribeiro, Ricardo |
author_role |
author |
author2 |
Matos, Andreia Afonso, José Mendes-Ferreira, Miguel Abade, Eduardo Teixeira, Eduardo Silva, Bruno Murawska-Ciałowicz, Eugenia Oliveira, Maria José Ribeiro, Ricardo |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Rocha-Rodrigues, Sílvia Matos, Andreia Afonso, José Mendes-Ferreira, Miguel Abade, Eduardo Teixeira, Eduardo Silva, Bruno Murawska-Ciałowicz, Eugenia Oliveira, Maria José Ribeiro, Ricardo |
dc.subject.por.fl_str_mv |
Cancer Periprostatic fat Physical activity Skeletal muscle Tumor microenvironment Visceral adiposity |
topic |
Cancer Periprostatic fat Physical activity Skeletal muscle Tumor microenvironment Visceral adiposity |
description |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-20T14:28:18Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/48046 |
url |
http://hdl.handle.net/10451/48046 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Int J Mol Sci. 2021 Apr 25;22(9):4469. 1661-6596 10.3390/ijms22094469 1422-0067 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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