Intestinal Microbiota and Sclerosis Lateral Amyotrophic

Detalhes bibliográficos
Autor(a) principal: Vilar, Mariana Dantas de Carvalho
Data de Publicação: 2022
Outros Autores: Vale, Sancha Helena de Lima, Rosado, Eliane Lopes, Dourado Júnior, Mário Emílio Teixeira, Brandão-Neto, José, Leite-Lais, Lúcia
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Revista Ciências em Saúde
Texto Completo: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1223
Resumo: The human gastrointestinal tract contains numerous microorganisms. This intestinal microbiota (IM) has a mutualistic relationship with the human organism, and it plays a fundamental role in regulating metabolic, endocrine, and immunological functions. Intestinal dysbiosis is associated with phenotypes of many chronic and inflammatory diseases. This association is explained by the functions of the IM and the existing bi-directional communication of the microbiota-intestine-brain axis. Studies have uncovered new evidence between the IM and neurodegenerative diseases recently, including amyotrophic lateral sclerosis (ALS). Given this, the present narrative review discusses didactically about IM, its functions, its relationship with the neuroimmune-endocrine system, and its association with neurodegenerative diseases, with emphasis on ALS.
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spelling Intestinal Microbiota and Sclerosis Lateral AmyotrophicMicrobiota Intestinal e Esclerose Lateral Amiotróficaamyotrophic lateral sclerosisdysbiosisgut microbiotaneurodegenerative diseasesdisbiosedoenças neurodegenerativasesclerose lateral amiotróficamicrobiota intestinalThe human gastrointestinal tract contains numerous microorganisms. This intestinal microbiota (IM) has a mutualistic relationship with the human organism, and it plays a fundamental role in regulating metabolic, endocrine, and immunological functions. Intestinal dysbiosis is associated with phenotypes of many chronic and inflammatory diseases. This association is explained by the functions of the IM and the existing bi-directional communication of the microbiota-intestine-brain axis. Studies have uncovered new evidence between the IM and neurodegenerative diseases recently, including amyotrophic lateral sclerosis (ALS). Given this, the present narrative review discusses didactically about IM, its functions, its relationship with the neuroimmune-endocrine system, and its association with neurodegenerative diseases, with emphasis on ALS.O trato gastrintestinal humano é povoado por uma grande quantidade de microrganismos. Essa microbiota intestinal (MI) tem uma relação de mutualismo com o organismo humano e desempenha papel fundamental na regulação de funções metabólicas, endócrinas e imunológicas. A disbiose intestinal está associada a fenótipos de várias doenças crônicas e inflamatórias. Essa associação é explicada pelas funções da MI e a existente comunicação bidirecional do eixo microbiota-intestino-cérebro.  Nos últimos anos, estudos têm mostrado novas evidências entre a MI e as doenças neurodegenerativas, incluindo a esclerose lateral amiotrófica (ELA). Diante disso, essa revisão narrativa discorre de forma didática sobre a MI, suas funções, sua relação com o sistema neuro-imuno-endócrino e sua associação com as doenças neurodegenerativas, com ênfase na ELA.AISI/HCI2022-03-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos parestextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/122310.21876/rcshci.v12i1.1223Revista Ciências em Saúde; v. 12 n. 1 (2022): Janeiro a Março de 2022; 3-13Health Sciences Journal; Vol 12 No 1 (2022): January to March 2022; 3-132236-378510.21876/rcshci.v12i1reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIengporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1223/789https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1223/790Copyright (c) 2022 Revista Ciências em Saúdehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessVilar, Mariana Dantas de CarvalhoVale, Sancha Helena de LimaRosado, Eliane LopesDourado Júnior, Mário Emílio TeixeiraBrandão-Neto, JoséLeite-Lais, Lúcia2022-05-16T00:33:17Zoai:ojs.portalrcs.hcitajuba.org.br:article/1223Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2022-05-16T00:33:17Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse
dc.title.none.fl_str_mv Intestinal Microbiota and Sclerosis Lateral Amyotrophic
Microbiota Intestinal e Esclerose Lateral Amiotrófica
title Intestinal Microbiota and Sclerosis Lateral Amyotrophic
spellingShingle Intestinal Microbiota and Sclerosis Lateral Amyotrophic
Vilar, Mariana Dantas de Carvalho
amyotrophic lateral sclerosis
dysbiosis
gut microbiota
neurodegenerative diseases
disbiose
doenças neurodegenerativas
esclerose lateral amiotrófica
microbiota intestinal
title_short Intestinal Microbiota and Sclerosis Lateral Amyotrophic
title_full Intestinal Microbiota and Sclerosis Lateral Amyotrophic
title_fullStr Intestinal Microbiota and Sclerosis Lateral Amyotrophic
title_full_unstemmed Intestinal Microbiota and Sclerosis Lateral Amyotrophic
title_sort Intestinal Microbiota and Sclerosis Lateral Amyotrophic
author Vilar, Mariana Dantas de Carvalho
author_facet Vilar, Mariana Dantas de Carvalho
Vale, Sancha Helena de Lima
Rosado, Eliane Lopes
Dourado Júnior, Mário Emílio Teixeira
Brandão-Neto, José
Leite-Lais, Lúcia
author_role author
author2 Vale, Sancha Helena de Lima
Rosado, Eliane Lopes
Dourado Júnior, Mário Emílio Teixeira
Brandão-Neto, José
Leite-Lais, Lúcia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vilar, Mariana Dantas de Carvalho
Vale, Sancha Helena de Lima
Rosado, Eliane Lopes
Dourado Júnior, Mário Emílio Teixeira
Brandão-Neto, José
Leite-Lais, Lúcia
dc.subject.por.fl_str_mv amyotrophic lateral sclerosis
dysbiosis
gut microbiota
neurodegenerative diseases
disbiose
doenças neurodegenerativas
esclerose lateral amiotrófica
microbiota intestinal
topic amyotrophic lateral sclerosis
dysbiosis
gut microbiota
neurodegenerative diseases
disbiose
doenças neurodegenerativas
esclerose lateral amiotrófica
microbiota intestinal
description The human gastrointestinal tract contains numerous microorganisms. This intestinal microbiota (IM) has a mutualistic relationship with the human organism, and it plays a fundamental role in regulating metabolic, endocrine, and immunological functions. Intestinal dysbiosis is associated with phenotypes of many chronic and inflammatory diseases. This association is explained by the functions of the IM and the existing bi-directional communication of the microbiota-intestine-brain axis. Studies have uncovered new evidence between the IM and neurodegenerative diseases recently, including amyotrophic lateral sclerosis (ALS). Given this, the present narrative review discusses didactically about IM, its functions, its relationship with the neuroimmune-endocrine system, and its association with neurodegenerative diseases, with emphasis on ALS.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer reviewed
Avaliado pelos pares
texto
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1223
10.21876/rcshci.v12i1.1223
url https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1223
identifier_str_mv 10.21876/rcshci.v12i1.1223
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1223/789
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1223/790
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Ciências em Saúde
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Ciências em Saúde
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AISI/HCI
publisher.none.fl_str_mv AISI/HCI
dc.source.none.fl_str_mv Revista Ciências em Saúde; v. 12 n. 1 (2022): Janeiro a Março de 2022; 3-13
Health Sciences Journal; Vol 12 No 1 (2022): January to March 2022; 3-13
2236-3785
10.21876/rcshci.v12i1
reponame:Revista Ciências em Saúde
instname:Hospital de Clínicas de Itajubá
instacron:HCI
instname_str Hospital de Clínicas de Itajubá
instacron_str HCI
institution HCI
reponame_str Revista Ciências em Saúde
collection Revista Ciências em Saúde
repository.name.fl_str_mv Revista Ciências em Saúde - Hospital de Clínicas de Itajubá
repository.mail.fl_str_mv rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br
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