Genetic factors and cancer: diagnosis, prognosis and future perspectives
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Revista Ciências em Saúde |
Texto Completo: | https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1218 |
Resumo: | Genetics is specifically responsible for several pathologies or, at the least, it is associated with a wide range of them, either as a primary causal agent (congenital genetic diseases) or secondary, being a factor within several possible for a given disease. One of the most critical genetic concepts is developed from the phenotype, equivalent to the genotype associated with the environment. In other words, for a condition to manifest itself, cancer, for example, we need a genetic alteration within the environment, which somehow influences carcinogenesis from stochastic or induced interactions. Cancer cases are approximately 80% and 90% associated with external causes, and environmental changes are mainly motivated by human actions, habits, and behavior, leading to an increased risk of different types of cancer. These changes lead to the formation of a cycle since man promotes environmental changes, leading to genetic modifications responsible for 10-20% of cancer formation. Although the percentage seems not to be significant, we have, in fact, several genetic mechanisms that will lead to the emergence of the most diverse types of cancer, including polymorphisms, mutations, oxidative stress, oncogenes, and genes that regulate the cell cycle, including apoptosis. |
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Genetic factors and cancer: diagnosis, prognosis and future perspectivesFatores genéticos e o câncer: diagnóstico, prognóstico e perspectivas futurasgeneticscanceroncogenesgenéticacânceroncogenesGenetics is specifically responsible for several pathologies or, at the least, it is associated with a wide range of them, either as a primary causal agent (congenital genetic diseases) or secondary, being a factor within several possible for a given disease. One of the most critical genetic concepts is developed from the phenotype, equivalent to the genotype associated with the environment. In other words, for a condition to manifest itself, cancer, for example, we need a genetic alteration within the environment, which somehow influences carcinogenesis from stochastic or induced interactions. Cancer cases are approximately 80% and 90% associated with external causes, and environmental changes are mainly motivated by human actions, habits, and behavior, leading to an increased risk of different types of cancer. These changes lead to the formation of a cycle since man promotes environmental changes, leading to genetic modifications responsible for 10-20% of cancer formation. Although the percentage seems not to be significant, we have, in fact, several genetic mechanisms that will lead to the emergence of the most diverse types of cancer, including polymorphisms, mutations, oxidative stress, oncogenes, and genes that regulate the cell cycle, including apoptosis.Se analisarmos a genética especificamente, a mesma é responsável por diversas patologias ou, no mínimo, está associada a uma grande gama delas, seja como agente causal primário (doenças genéticas congênitas) ou secundário, sendo um fator dentro de diversos possíveis para uma determinada doença. Um dos mais importantes conceitos genéticos é formulado a partir do fenótipo, equivalente ao genótipo associado ao ambiente. Ou seja, para que haja a manifestação de uma condição, câncer, por exemplo, temos que uma alteração genética junto ao ambiente, que de alguma forma influenciam na carcinogênese a partir de interações estocásticas ou induzidas. Os casos de câncer são aproximadamente 80% a 90% associados a causas externas, sendo que mudanças ambientais são motivadas, em sua maioria, por ações do próprio homem, além de hábitos e comportamento, levando ao aumento no risco de diferentes tipos de câncer. Estas mudanças acarretam a formação de um ciclo, uma vez que o homem promove mudanças ambientais e estas podem levar às modificações genéticas, responsáveis por 10-20% na formação do câncer. Embora a porcentagem pareça não ser grande, temos, de fato, vários mecanismos genéticos que levarão ao surgimento dos mais diversos tipos de câncer, entre eles os polimorfismos, mutações, estresse oxidativo, oncogenes e genes reguladores do ciclo celular, incluindo da apoptose.AISI/HCI2021-09-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionInvited articleArtigo de convidadotextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/121810.21876/rcshci.v11i3.1218Revista Ciências em Saúde; v. 11 n. 3 (2021): Julho a Setembro de 2021; 1-2Health Sciences Journal; Vol 11 No 3 (2021): July to September 2021; 1-22236-378510.21876/rcshci.v11i3reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIengporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1218/727https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1218/728Copyright (c) 2021 Revista Ciências em Saúdehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessBomfim, Fernando Russo Costa do2021-09-30T19:27:42Zoai:ojs.portalrcs.hcitajuba.org.br:article/1218Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2021-09-30T19:27:42Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse |
dc.title.none.fl_str_mv |
Genetic factors and cancer: diagnosis, prognosis and future perspectives Fatores genéticos e o câncer: diagnóstico, prognóstico e perspectivas futuras |
title |
Genetic factors and cancer: diagnosis, prognosis and future perspectives |
spellingShingle |
Genetic factors and cancer: diagnosis, prognosis and future perspectives Bomfim, Fernando Russo Costa do genetics cancer oncogenes genética câncer oncogenes |
title_short |
Genetic factors and cancer: diagnosis, prognosis and future perspectives |
title_full |
Genetic factors and cancer: diagnosis, prognosis and future perspectives |
title_fullStr |
Genetic factors and cancer: diagnosis, prognosis and future perspectives |
title_full_unstemmed |
Genetic factors and cancer: diagnosis, prognosis and future perspectives |
title_sort |
Genetic factors and cancer: diagnosis, prognosis and future perspectives |
author |
Bomfim, Fernando Russo Costa do |
author_facet |
Bomfim, Fernando Russo Costa do |
author_role |
author |
dc.contributor.author.fl_str_mv |
Bomfim, Fernando Russo Costa do |
dc.subject.por.fl_str_mv |
genetics cancer oncogenes genética câncer oncogenes |
topic |
genetics cancer oncogenes genética câncer oncogenes |
description |
Genetics is specifically responsible for several pathologies or, at the least, it is associated with a wide range of them, either as a primary causal agent (congenital genetic diseases) or secondary, being a factor within several possible for a given disease. One of the most critical genetic concepts is developed from the phenotype, equivalent to the genotype associated with the environment. In other words, for a condition to manifest itself, cancer, for example, we need a genetic alteration within the environment, which somehow influences carcinogenesis from stochastic or induced interactions. Cancer cases are approximately 80% and 90% associated with external causes, and environmental changes are mainly motivated by human actions, habits, and behavior, leading to an increased risk of different types of cancer. These changes lead to the formation of a cycle since man promotes environmental changes, leading to genetic modifications responsible for 10-20% of cancer formation. Although the percentage seems not to be significant, we have, in fact, several genetic mechanisms that will lead to the emergence of the most diverse types of cancer, including polymorphisms, mutations, oxidative stress, oncogenes, and genes that regulate the cell cycle, including apoptosis. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Invited article Artigo de convidado texto info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1218 10.21876/rcshci.v11i3.1218 |
url |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1218 |
identifier_str_mv |
10.21876/rcshci.v11i3.1218 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1218/727 https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1218/728 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Revista Ciências em Saúde https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Revista Ciências em Saúde https://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
AISI/HCI |
publisher.none.fl_str_mv |
AISI/HCI |
dc.source.none.fl_str_mv |
Revista Ciências em Saúde; v. 11 n. 3 (2021): Julho a Setembro de 2021; 1-2 Health Sciences Journal; Vol 11 No 3 (2021): July to September 2021; 1-2 2236-3785 10.21876/rcshci.v11i3 reponame:Revista Ciências em Saúde instname:Hospital de Clínicas de Itajubá instacron:HCI |
instname_str |
Hospital de Clínicas de Itajubá |
instacron_str |
HCI |
institution |
HCI |
reponame_str |
Revista Ciências em Saúde |
collection |
Revista Ciências em Saúde |
repository.name.fl_str_mv |
Revista Ciências em Saúde - Hospital de Clínicas de Itajubá |
repository.mail.fl_str_mv |
rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br |
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1797068963287400448 |