Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Revista Ciências em Saúde |
Texto Completo: | https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047 |
Resumo: | Objectives: The primary objective of this study will be to evaluate the efficacy of subcutaneous and peri-arterial isosorbide mononitrate in preventing occlusion of the radial artery (ORA) after percutaneous coronary procedures (PCP) performed by the transradial approach (TRA). As secondary objectives, define the incidence of ORA in the institution and assess variables related to the risk of occlusion. Methods: Single-center, double-blind, randomized study, including in- and outpatients from a high complexity hospital, admitted to performing PCP, diagnostic or therapeutic, by TRA, in stable coronary conditions (elective) or acute coronary syndrome. The sample will be randomly divided into a group that will receive the medication and a control group. All participants will be submitted to palpatory assessment of radial artery patency and the Barbeau inverse test within 24 h and seven days after the procedure. This will be the first study to evaluate isosorbide mononitrate as an accessible and inexpensive pharmacological method for preventing OAR after PCP by VTR. |
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Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocolEstudo duplo-cego, unicêntrico, randomizado, avaliando a eficácia o mononitrato de isossorbida na prevenção da oclusão de artéria radial comparado ao placebo em pacientes submetidos a procedimento coronariano percutâneo eletivo: protocolo de estudoisosorbideradial arterypercutaneous coronary interventionisossorbidaartéria radialintervenção coronária percutâneaObjectives: The primary objective of this study will be to evaluate the efficacy of subcutaneous and peri-arterial isosorbide mononitrate in preventing occlusion of the radial artery (ORA) after percutaneous coronary procedures (PCP) performed by the transradial approach (TRA). As secondary objectives, define the incidence of ORA in the institution and assess variables related to the risk of occlusion. Methods: Single-center, double-blind, randomized study, including in- and outpatients from a high complexity hospital, admitted to performing PCP, diagnostic or therapeutic, by TRA, in stable coronary conditions (elective) or acute coronary syndrome. The sample will be randomly divided into a group that will receive the medication and a control group. All participants will be submitted to palpatory assessment of radial artery patency and the Barbeau inverse test within 24 h and seven days after the procedure. This will be the first study to evaluate isosorbide mononitrate as an accessible and inexpensive pharmacological method for preventing OAR after PCP by VTR.Objetivos: O objetivo primário deste estudo será avaliar a eficácia do mononitrato de isossorbida subcutâneo e peri-arterial na prevenção da oclusão da artéria radial (OAR) após procedimento coronariano percutâneo (PCP) realizado pela via transradial (VTR). Como objetivos secundários, definir a incidência de OAR em no serviço assim como avaliar variáveis relacionadas ao risco de oclusão.Métodos: Estudo unicêntrico, duplo-cego, randomizado, onde serão incluídos pacientes internados e eletivos de hospital de alta complexidade, que derem entrada para a realização de PCP, diagnóstico ou terapêutico, por VTR, em quadros coronarianos estáveis (eletivos) ou em síndromes coronarianas agudas. A amostra será dividida de forma randômica em grupo que receberá a medicação e um grupo controle. Todos os participantes serão submetidos a avaliação palpatória da patência da artéria radial e pelo teste inverso de Barbeau nas 24 horas e sete dias após o procedimento. Este será o primeiro estudo a avaliar o mononitrato de isossorbida como método farmacológico acessível e barato para prevenção da OAR após PCP por VTR.AISI/HCI2021-03-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos parestextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdftext/xmltext/htmlhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/104710.21876/rcshci.v11i1.1047Revista Ciências em Saúde; v. 11 n. 1 (2021): Janeiro a Março de 2021; 61-68Health Sciences Journal; Vol 11 No 1 (2021): January to March 2021; 61-682236-378510.21876/rcshci.v11i1reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIporenghttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047/677https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047/678https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047/696https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047/697Copyright (c) 2021 Revista Ciências em Saúdehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccess Janella, Bruno LaurentiMatsuda, Camila NaomiPereira, Rafael DaherMagalhães, Jean MichelSilva, Marcilene Aparecida da2021-03-27T16:17:05Zoai:ojs.portalrcs.hcitajuba.org.br:article/1047Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2021-03-27T16:17:05Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse |
dc.title.none.fl_str_mv |
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol Estudo duplo-cego, unicêntrico, randomizado, avaliando a eficácia o mononitrato de isossorbida na prevenção da oclusão de artéria radial comparado ao placebo em pacientes submetidos a procedimento coronariano percutâneo eletivo: protocolo de estudo |
title |
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol |
spellingShingle |
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol Janella, Bruno Laurenti isosorbide radial artery percutaneous coronary intervention isossorbida artéria radial intervenção coronária percutânea |
title_short |
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol |
title_full |
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol |
title_fullStr |
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol |
title_full_unstemmed |
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol |
title_sort |
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol |
author |
Janella, Bruno Laurenti |
author_facet |
Janella, Bruno Laurenti Matsuda, Camila Naomi Pereira, Rafael Daher Magalhães, Jean Michel Silva, Marcilene Aparecida da |
author_role |
author |
author2 |
Matsuda, Camila Naomi Pereira, Rafael Daher Magalhães, Jean Michel Silva, Marcilene Aparecida da |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Janella, Bruno Laurenti Matsuda, Camila Naomi Pereira, Rafael Daher Magalhães, Jean Michel Silva, Marcilene Aparecida da |
dc.subject.por.fl_str_mv |
isosorbide radial artery percutaneous coronary intervention isossorbida artéria radial intervenção coronária percutânea |
topic |
isosorbide radial artery percutaneous coronary intervention isossorbida artéria radial intervenção coronária percutânea |
description |
Objectives: The primary objective of this study will be to evaluate the efficacy of subcutaneous and peri-arterial isosorbide mononitrate in preventing occlusion of the radial artery (ORA) after percutaneous coronary procedures (PCP) performed by the transradial approach (TRA). As secondary objectives, define the incidence of ORA in the institution and assess variables related to the risk of occlusion. Methods: Single-center, double-blind, randomized study, including in- and outpatients from a high complexity hospital, admitted to performing PCP, diagnostic or therapeutic, by TRA, in stable coronary conditions (elective) or acute coronary syndrome. The sample will be randomly divided into a group that will receive the medication and a control group. All participants will be submitted to palpatory assessment of radial artery patency and the Barbeau inverse test within 24 h and seven days after the procedure. This will be the first study to evaluate isosorbide mononitrate as an accessible and inexpensive pharmacological method for preventing OAR after PCP by VTR. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer reviewed Avaliado pelos pares texto info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047 10.21876/rcshci.v11i1.1047 |
url |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047 |
identifier_str_mv |
10.21876/rcshci.v11i1.1047 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047/677 https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047/678 https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047/696 https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1047/697 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Revista Ciências em Saúde https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Revista Ciências em Saúde https://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf text/xml text/html |
dc.publisher.none.fl_str_mv |
AISI/HCI |
publisher.none.fl_str_mv |
AISI/HCI |
dc.source.none.fl_str_mv |
Revista Ciências em Saúde; v. 11 n. 1 (2021): Janeiro a Março de 2021; 61-68 Health Sciences Journal; Vol 11 No 1 (2021): January to March 2021; 61-68 2236-3785 10.21876/rcshci.v11i1 reponame:Revista Ciências em Saúde instname:Hospital de Clínicas de Itajubá instacron:HCI |
instname_str |
Hospital de Clínicas de Itajubá |
instacron_str |
HCI |
institution |
HCI |
reponame_str |
Revista Ciências em Saúde |
collection |
Revista Ciências em Saúde |
repository.name.fl_str_mv |
Revista Ciências em Saúde - Hospital de Clínicas de Itajubá |
repository.mail.fl_str_mv |
rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br |
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1797068962846998528 |