Immunotherapeutic perspectives for COVID-19

Detalhes bibliográficos
Autor(a) principal: Cavalcanti, Lucas Gomes de Hollanda
Data de Publicação: 2020
Outros Autores: Oliveira, Luciana Xavier, Bustamante, Melina Pezzo, Andrade, Marileia Chaves
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Ciências em Saúde
Texto Completo: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002
Resumo: With the appearance of COVID-19, constant research on SARS-CoV-2 infection and its therapeutic prospects have begun. With an evident contribution of immunological activity to the pathogenesis of COVID-19, we highlight the main immunotherapeutic perspectives under its development. The involvement of neutrophilia and the formation of NETs (Neutrophil Extracellular Traps) is still being investigated as the clinical situation is worsening. One way to mitigate disease’s severity is by controlling neutrophil activity and the formation of NETs. Another way is to administer convalescent plasma or intravenous immunoglobulin (IgG) that can neutralize the entry of the virus into cells and modulate the immune response. However, the treatments are not yet definitive and lack favorable results.
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spelling Immunotherapeutic perspectives for COVID-19Perspectivas imunoterapêuticas para COVID-19COVID-19SARS-CoV-2immunotherapyimmunologyCOVID-19COVID-19SARS-CoV-2imunoterapiaimunologiaCOVID-19With the appearance of COVID-19, constant research on SARS-CoV-2 infection and its therapeutic prospects have begun. With an evident contribution of immunological activity to the pathogenesis of COVID-19, we highlight the main immunotherapeutic perspectives under its development. The involvement of neutrophilia and the formation of NETs (Neutrophil Extracellular Traps) is still being investigated as the clinical situation is worsening. One way to mitigate disease’s severity is by controlling neutrophil activity and the formation of NETs. Another way is to administer convalescent plasma or intravenous immunoglobulin (IgG) that can neutralize the entry of the virus into cells and modulate the immune response. However, the treatments are not yet definitive and lack favorable results.Com o surgimento da COVID-19, iniciou-se uma constante pesquisa sobre a infecção pelo SARS-CoV-2 e suas perspectivas terapêuticas. Com evidente contribuição da atividade imunológica na patogênese da COVID-19, destacam-se as principais perspectivas imunoterapêuticas em desenvolvimento. Ainda, se investiga o envolvimento da neutrofilia e da formação de Neutrophil Extracellular Traps (NETs) no agravamento do quadro clínico. Portanto, acredita-se que controlar atividade de neutrófilos e a formação de NETs seja um dos caminhos para atenuar a gravidade da doença. Outra proposta é a administração de plasma convalescente ou imunoglobulina (IgG) intravenosa, que neutralizariam a entrada do vírus nas células e modularia a resposta imune. No entanto, os tratamentos ainda não são definitivos e carecem de resultados favoráveis.AISI/HCI2020-11-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos parestextoinfo:eu-repo/semantics/otherapplication/pdftext/htmltext/xmlhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/100210.21876/rcshci.v10i4.1002Revista Ciências em Saúde; v. 10 n. 4 (2020): Outubro a Dezembro de 2020; 6-9Health Sciences Journal; Vol 10 No 4 (2020): October to December 2020; 6-92236-378510.21876/rcshci.v10i4reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002/608https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002/646https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002/647Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDEhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessCavalcanti, Lucas Gomes de HollandaOliveira, Luciana XavierBustamante, Melina PezzoAndrade, Marileia Chaves2021-01-07T16:14:31Zoai:ojs.portalrcs.hcitajuba.org.br:article/1002Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2021-01-07T16:14:31Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse
dc.title.none.fl_str_mv Immunotherapeutic perspectives for COVID-19
Perspectivas imunoterapêuticas para COVID-19
title Immunotherapeutic perspectives for COVID-19
spellingShingle Immunotherapeutic perspectives for COVID-19
Cavalcanti, Lucas Gomes de Hollanda
COVID-19
SARS-CoV-2
immunotherapy
immunology
COVID-19
COVID-19
SARS-CoV-2
imunoterapia
imunologia
COVID-19
title_short Immunotherapeutic perspectives for COVID-19
title_full Immunotherapeutic perspectives for COVID-19
title_fullStr Immunotherapeutic perspectives for COVID-19
title_full_unstemmed Immunotherapeutic perspectives for COVID-19
title_sort Immunotherapeutic perspectives for COVID-19
author Cavalcanti, Lucas Gomes de Hollanda
author_facet Cavalcanti, Lucas Gomes de Hollanda
Oliveira, Luciana Xavier
Bustamante, Melina Pezzo
Andrade, Marileia Chaves
author_role author
author2 Oliveira, Luciana Xavier
Bustamante, Melina Pezzo
Andrade, Marileia Chaves
author2_role author
author
author
dc.contributor.author.fl_str_mv Cavalcanti, Lucas Gomes de Hollanda
Oliveira, Luciana Xavier
Bustamante, Melina Pezzo
Andrade, Marileia Chaves
dc.subject.por.fl_str_mv COVID-19
SARS-CoV-2
immunotherapy
immunology
COVID-19
COVID-19
SARS-CoV-2
imunoterapia
imunologia
COVID-19
topic COVID-19
SARS-CoV-2
immunotherapy
immunology
COVID-19
COVID-19
SARS-CoV-2
imunoterapia
imunologia
COVID-19
description With the appearance of COVID-19, constant research on SARS-CoV-2 infection and its therapeutic prospects have begun. With an evident contribution of immunological activity to the pathogenesis of COVID-19, we highlight the main immunotherapeutic perspectives under its development. The involvement of neutrophilia and the formation of NETs (Neutrophil Extracellular Traps) is still being investigated as the clinical situation is worsening. One way to mitigate disease’s severity is by controlling neutrophil activity and the formation of NETs. Another way is to administer convalescent plasma or intravenous immunoglobulin (IgG) that can neutralize the entry of the virus into cells and modulate the immune response. However, the treatments are not yet definitive and lack favorable results.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer reviewed
Avaliado pelos pares
texto
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002
10.21876/rcshci.v10i4.1002
url https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002
identifier_str_mv 10.21876/rcshci.v10i4.1002
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002/608
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002/646
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002/647
dc.rights.driver.fl_str_mv Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDE
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDE
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
text/xml
dc.publisher.none.fl_str_mv AISI/HCI
publisher.none.fl_str_mv AISI/HCI
dc.source.none.fl_str_mv Revista Ciências em Saúde; v. 10 n. 4 (2020): Outubro a Dezembro de 2020; 6-9
Health Sciences Journal; Vol 10 No 4 (2020): October to December 2020; 6-9
2236-3785
10.21876/rcshci.v10i4
reponame:Revista Ciências em Saúde
instname:Hospital de Clínicas de Itajubá
instacron:HCI
instname_str Hospital de Clínicas de Itajubá
instacron_str HCI
institution HCI
reponame_str Revista Ciências em Saúde
collection Revista Ciências em Saúde
repository.name.fl_str_mv Revista Ciências em Saúde - Hospital de Clínicas de Itajubá
repository.mail.fl_str_mv rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br
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