Polymedication in sodium warfarin users of the Public Health System and associated variables

Detalhes bibliográficos
Autor(a) principal: Kleibert, Karine Raquel Uhdich
Data de Publicação: 2020
Outros Autores: Hermann, Emelli Fin, Nunes, Paula Lorenzoni, Schneider, Aline, Stumm, Eniva Miladi Fernandes, Colet, Christiane de Fátima
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Ciências em Saúde
Texto Completo: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900
Resumo: Objective: To verify the use of polymedication in warfarin users and its association with clinical variables. Methods: cross-sectional study, with warfarin users, of both sexes. For data collection, a structured questionnaire was used, with open and closed questions, on socioeconomic, clinical data and aspects related to pharmacotherapy (adverse reactions, drug interactions, systemic blood pressure indexes, fasting glucose values, self-medication practice, overweight, bleeding episodes and thromboembolism). Results: the average age of the participants was 69.1 ± 13.6 years, mostly female (64.6%), married (43.8%), and white (85.4%). As for education, 41.7% attended incomplete elementary school. Polymedicated patients totaled 89.6%, and patients using ten or more medications, 31.3%. The average number of medications per patient was 8.2 ± 3.5. There was an association between polymedication, occurrence of adverse reactions (94.7% vs 5.3%; p = 0.042) and the number of potential drug interactions, total (8.9 ± 5.0 vs 1.2 ± 1.6; p = 0.001) and severe (3.1 ± 2.4 vs 0.4 ± 0.6; p = 0.017). The other variables studied were not associated with polymedication. Conclusion: the results showed negative interference from polymedication in the occurrence of adverse reactions, and in the potential total and serious drug interactions. There is a need to know the impact of these variables on the polymedicated anticoagulated patient to plan risk reduction strategies and to optimize benefits.
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spelling Polymedication in sodium warfarin users of the Public Health System and associated variablesPolimedicação em usuários de varfarina sódica do Sistema Único de Saúde e variáveis associadasDrug-related side effects and adverse reactionsWarfarinDrug interactionsVarfarinaEfeitos Colaterais e Reações Adversas Relacionados a MedicamentosInterações medicamentosas.Objective: To verify the use of polymedication in warfarin users and its association with clinical variables. Methods: cross-sectional study, with warfarin users, of both sexes. For data collection, a structured questionnaire was used, with open and closed questions, on socioeconomic, clinical data and aspects related to pharmacotherapy (adverse reactions, drug interactions, systemic blood pressure indexes, fasting glucose values, self-medication practice, overweight, bleeding episodes and thromboembolism). Results: the average age of the participants was 69.1 ± 13.6 years, mostly female (64.6%), married (43.8%), and white (85.4%). As for education, 41.7% attended incomplete elementary school. Polymedicated patients totaled 89.6%, and patients using ten or more medications, 31.3%. The average number of medications per patient was 8.2 ± 3.5. There was an association between polymedication, occurrence of adverse reactions (94.7% vs 5.3%; p = 0.042) and the number of potential drug interactions, total (8.9 ± 5.0 vs 1.2 ± 1.6; p = 0.001) and severe (3.1 ± 2.4 vs 0.4 ± 0.6; p = 0.017). The other variables studied were not associated with polymedication. Conclusion: the results showed negative interference from polymedication in the occurrence of adverse reactions, and in the potential total and serious drug interactions. There is a need to know the impact of these variables on the polymedicated anticoagulated patient to plan risk reduction strategies and to optimize benefits.Objetivo: Verificar o uso da polimedicação em usuários de varfarina e sua associação com variáveis clínicas. Métodos: estudo transversal, com usuários de varfarina, de ambos os sexos. Para a coleta dos dados foi utilizado questionário estruturado, com perguntas abertas e fechadas, sobre dados socioeconômicos, clínicos e aspectos relacionados à farmacoterapia (reações adversas, interações medicamentosas, índices de pressão arterial sistêmica, valores de glicemia de jejum, prática de automedicação, sobrepeso, episódios de sangramento e de tromboembolismo). Resultados: a média de idade dos participantes foi de 69,1 ± 13,6 anos, maioria do sexo feminino (64,6%), casado (43,8%), e de etnia branca (85,4%). Quanto a escolaridade, 41,7% cursaram ensino fundamental incompleto. Os pacientes polimedicados totalizaram 89,6%, e os pacientes em uso de dez ou mais medicamentos, 31,3%. A média de medicamentos foi 8,2 ± 3,5 fármacos/paciente. Ocorreu associação entre polimedicação, ocorrência de reações adversas (94,7% vs 5,3%; p = 0,042) e o número de potenciais interações medicamentosas, totais (8,9 ± 5,0 vs 1,2 ± 1,6; p = 0,001) e graves (3,1 ± 2,4 vs 0,4 ± 0,6; p = 0,017). As demais variáveis estudadas não foram associadas com a polimedicação. Conclusão: os resultados demonstraram interferência negativa da polimedicação na ocorrência de reações adversas, e nas potenciais interações medicamentosas totais e graves. Há necessidade de conhecer o impacto destas variáveis no paciente anticoagulado polimedicado para o planejamento de estratégias de redução de riscos e para a otimização dos benefícios.AISI/HCI2020-05-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos paresartigo originalapplication/pdfhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/90010.21876/rcshci.v10i2.900Revista Ciências em Saúde; v. 10 n. 2 (2020): Abril a Junho de 2020; 28-35Health Sciences Journal; Vol 10 No 2 (2020): April to June 2020; 28-352236-378510.21876/rcshci.v10i2reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900/540Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDEhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessKleibert, Karine Raquel UhdichHermann, Emelli FinNunes, Paula LorenzoniSchneider, AlineStumm, Eniva Miladi FernandesColet, Christiane de Fátima2020-09-03T04:10:54Zoai:ojs.portalrcs.hcitajuba.org.br:article/900Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2020-09-03T04:10:54Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse
dc.title.none.fl_str_mv Polymedication in sodium warfarin users of the Public Health System and associated variables
Polimedicação em usuários de varfarina sódica do Sistema Único de Saúde e variáveis associadas
title Polymedication in sodium warfarin users of the Public Health System and associated variables
spellingShingle Polymedication in sodium warfarin users of the Public Health System and associated variables
Kleibert, Karine Raquel Uhdich
Drug-related side effects and adverse reactions
Warfarin
Drug interactions
Varfarina
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Interações medicamentosas.
title_short Polymedication in sodium warfarin users of the Public Health System and associated variables
title_full Polymedication in sodium warfarin users of the Public Health System and associated variables
title_fullStr Polymedication in sodium warfarin users of the Public Health System and associated variables
title_full_unstemmed Polymedication in sodium warfarin users of the Public Health System and associated variables
title_sort Polymedication in sodium warfarin users of the Public Health System and associated variables
author Kleibert, Karine Raquel Uhdich
author_facet Kleibert, Karine Raquel Uhdich
Hermann, Emelli Fin
Nunes, Paula Lorenzoni
Schneider, Aline
Stumm, Eniva Miladi Fernandes
Colet, Christiane de Fátima
author_role author
author2 Hermann, Emelli Fin
Nunes, Paula Lorenzoni
Schneider, Aline
Stumm, Eniva Miladi Fernandes
Colet, Christiane de Fátima
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Kleibert, Karine Raquel Uhdich
Hermann, Emelli Fin
Nunes, Paula Lorenzoni
Schneider, Aline
Stumm, Eniva Miladi Fernandes
Colet, Christiane de Fátima
dc.subject.por.fl_str_mv Drug-related side effects and adverse reactions
Warfarin
Drug interactions
Varfarina
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Interações medicamentosas.
topic Drug-related side effects and adverse reactions
Warfarin
Drug interactions
Varfarina
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Interações medicamentosas.
description Objective: To verify the use of polymedication in warfarin users and its association with clinical variables. Methods: cross-sectional study, with warfarin users, of both sexes. For data collection, a structured questionnaire was used, with open and closed questions, on socioeconomic, clinical data and aspects related to pharmacotherapy (adverse reactions, drug interactions, systemic blood pressure indexes, fasting glucose values, self-medication practice, overweight, bleeding episodes and thromboembolism). Results: the average age of the participants was 69.1 ± 13.6 years, mostly female (64.6%), married (43.8%), and white (85.4%). As for education, 41.7% attended incomplete elementary school. Polymedicated patients totaled 89.6%, and patients using ten or more medications, 31.3%. The average number of medications per patient was 8.2 ± 3.5. There was an association between polymedication, occurrence of adverse reactions (94.7% vs 5.3%; p = 0.042) and the number of potential drug interactions, total (8.9 ± 5.0 vs 1.2 ± 1.6; p = 0.001) and severe (3.1 ± 2.4 vs 0.4 ± 0.6; p = 0.017). The other variables studied were not associated with polymedication. Conclusion: the results showed negative interference from polymedication in the occurrence of adverse reactions, and in the potential total and serious drug interactions. There is a need to know the impact of these variables on the polymedicated anticoagulated patient to plan risk reduction strategies and to optimize benefits.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-02
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer reviewed
Avaliado pelos pares
artigo original
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900
10.21876/rcshci.v10i2.900
url https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900
identifier_str_mv 10.21876/rcshci.v10i2.900
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900/540
dc.rights.driver.fl_str_mv Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDE
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDE
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv AISI/HCI
publisher.none.fl_str_mv AISI/HCI
dc.source.none.fl_str_mv Revista Ciências em Saúde; v. 10 n. 2 (2020): Abril a Junho de 2020; 28-35
Health Sciences Journal; Vol 10 No 2 (2020): April to June 2020; 28-35
2236-3785
10.21876/rcshci.v10i2
reponame:Revista Ciências em Saúde
instname:Hospital de Clínicas de Itajubá
instacron:HCI
instname_str Hospital de Clínicas de Itajubá
instacron_str HCI
institution HCI
reponame_str Revista Ciências em Saúde
collection Revista Ciências em Saúde
repository.name.fl_str_mv Revista Ciências em Saúde - Hospital de Clínicas de Itajubá
repository.mail.fl_str_mv rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br
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