Polymedication in sodium warfarin users of the Public Health System and associated variables
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Ciências em Saúde |
Texto Completo: | https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900 |
Resumo: | Objective: To verify the use of polymedication in warfarin users and its association with clinical variables. Methods: cross-sectional study, with warfarin users, of both sexes. For data collection, a structured questionnaire was used, with open and closed questions, on socioeconomic, clinical data and aspects related to pharmacotherapy (adverse reactions, drug interactions, systemic blood pressure indexes, fasting glucose values, self-medication practice, overweight, bleeding episodes and thromboembolism). Results: the average age of the participants was 69.1 ± 13.6 years, mostly female (64.6%), married (43.8%), and white (85.4%). As for education, 41.7% attended incomplete elementary school. Polymedicated patients totaled 89.6%, and patients using ten or more medications, 31.3%. The average number of medications per patient was 8.2 ± 3.5. There was an association between polymedication, occurrence of adverse reactions (94.7% vs 5.3%; p = 0.042) and the number of potential drug interactions, total (8.9 ± 5.0 vs 1.2 ± 1.6; p = 0.001) and severe (3.1 ± 2.4 vs 0.4 ± 0.6; p = 0.017). The other variables studied were not associated with polymedication. Conclusion: the results showed negative interference from polymedication in the occurrence of adverse reactions, and in the potential total and serious drug interactions. There is a need to know the impact of these variables on the polymedicated anticoagulated patient to plan risk reduction strategies and to optimize benefits. |
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Polymedication in sodium warfarin users of the Public Health System and associated variablesPolimedicação em usuários de varfarina sódica do Sistema Único de Saúde e variáveis associadasDrug-related side effects and adverse reactionsWarfarinDrug interactionsVarfarinaEfeitos Colaterais e Reações Adversas Relacionados a MedicamentosInterações medicamentosas.Objective: To verify the use of polymedication in warfarin users and its association with clinical variables. Methods: cross-sectional study, with warfarin users, of both sexes. For data collection, a structured questionnaire was used, with open and closed questions, on socioeconomic, clinical data and aspects related to pharmacotherapy (adverse reactions, drug interactions, systemic blood pressure indexes, fasting glucose values, self-medication practice, overweight, bleeding episodes and thromboembolism). Results: the average age of the participants was 69.1 ± 13.6 years, mostly female (64.6%), married (43.8%), and white (85.4%). As for education, 41.7% attended incomplete elementary school. Polymedicated patients totaled 89.6%, and patients using ten or more medications, 31.3%. The average number of medications per patient was 8.2 ± 3.5. There was an association between polymedication, occurrence of adverse reactions (94.7% vs 5.3%; p = 0.042) and the number of potential drug interactions, total (8.9 ± 5.0 vs 1.2 ± 1.6; p = 0.001) and severe (3.1 ± 2.4 vs 0.4 ± 0.6; p = 0.017). The other variables studied were not associated with polymedication. Conclusion: the results showed negative interference from polymedication in the occurrence of adverse reactions, and in the potential total and serious drug interactions. There is a need to know the impact of these variables on the polymedicated anticoagulated patient to plan risk reduction strategies and to optimize benefits.Objetivo: Verificar o uso da polimedicação em usuários de varfarina e sua associação com variáveis clínicas. Métodos: estudo transversal, com usuários de varfarina, de ambos os sexos. Para a coleta dos dados foi utilizado questionário estruturado, com perguntas abertas e fechadas, sobre dados socioeconômicos, clínicos e aspectos relacionados à farmacoterapia (reações adversas, interações medicamentosas, índices de pressão arterial sistêmica, valores de glicemia de jejum, prática de automedicação, sobrepeso, episódios de sangramento e de tromboembolismo). Resultados: a média de idade dos participantes foi de 69,1 ± 13,6 anos, maioria do sexo feminino (64,6%), casado (43,8%), e de etnia branca (85,4%). Quanto a escolaridade, 41,7% cursaram ensino fundamental incompleto. Os pacientes polimedicados totalizaram 89,6%, e os pacientes em uso de dez ou mais medicamentos, 31,3%. A média de medicamentos foi 8,2 ± 3,5 fármacos/paciente. Ocorreu associação entre polimedicação, ocorrência de reações adversas (94,7% vs 5,3%; p = 0,042) e o número de potenciais interações medicamentosas, totais (8,9 ± 5,0 vs 1,2 ± 1,6; p = 0,001) e graves (3,1 ± 2,4 vs 0,4 ± 0,6; p = 0,017). As demais variáveis estudadas não foram associadas com a polimedicação. Conclusão: os resultados demonstraram interferência negativa da polimedicação na ocorrência de reações adversas, e nas potenciais interações medicamentosas totais e graves. Há necessidade de conhecer o impacto destas variáveis no paciente anticoagulado polimedicado para o planejamento de estratégias de redução de riscos e para a otimização dos benefícios.AISI/HCI2020-05-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos paresartigo originalapplication/pdfhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/90010.21876/rcshci.v10i2.900Revista Ciências em Saúde; v. 10 n. 2 (2020): Abril a Junho de 2020; 28-35Health Sciences Journal; Vol 10 No 2 (2020): April to June 2020; 28-352236-378510.21876/rcshci.v10i2reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900/540Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDEhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessKleibert, Karine Raquel UhdichHermann, Emelli FinNunes, Paula LorenzoniSchneider, AlineStumm, Eniva Miladi FernandesColet, Christiane de Fátima2020-09-03T04:10:54Zoai:ojs.portalrcs.hcitajuba.org.br:article/900Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2020-09-03T04:10:54Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse |
dc.title.none.fl_str_mv |
Polymedication in sodium warfarin users of the Public Health System and associated variables Polimedicação em usuários de varfarina sódica do Sistema Único de Saúde e variáveis associadas |
title |
Polymedication in sodium warfarin users of the Public Health System and associated variables |
spellingShingle |
Polymedication in sodium warfarin users of the Public Health System and associated variables Kleibert, Karine Raquel Uhdich Drug-related side effects and adverse reactions Warfarin Drug interactions Varfarina Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Interações medicamentosas. |
title_short |
Polymedication in sodium warfarin users of the Public Health System and associated variables |
title_full |
Polymedication in sodium warfarin users of the Public Health System and associated variables |
title_fullStr |
Polymedication in sodium warfarin users of the Public Health System and associated variables |
title_full_unstemmed |
Polymedication in sodium warfarin users of the Public Health System and associated variables |
title_sort |
Polymedication in sodium warfarin users of the Public Health System and associated variables |
author |
Kleibert, Karine Raquel Uhdich |
author_facet |
Kleibert, Karine Raquel Uhdich Hermann, Emelli Fin Nunes, Paula Lorenzoni Schneider, Aline Stumm, Eniva Miladi Fernandes Colet, Christiane de Fátima |
author_role |
author |
author2 |
Hermann, Emelli Fin Nunes, Paula Lorenzoni Schneider, Aline Stumm, Eniva Miladi Fernandes Colet, Christiane de Fátima |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Kleibert, Karine Raquel Uhdich Hermann, Emelli Fin Nunes, Paula Lorenzoni Schneider, Aline Stumm, Eniva Miladi Fernandes Colet, Christiane de Fátima |
dc.subject.por.fl_str_mv |
Drug-related side effects and adverse reactions Warfarin Drug interactions Varfarina Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Interações medicamentosas. |
topic |
Drug-related side effects and adverse reactions Warfarin Drug interactions Varfarina Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Interações medicamentosas. |
description |
Objective: To verify the use of polymedication in warfarin users and its association with clinical variables. Methods: cross-sectional study, with warfarin users, of both sexes. For data collection, a structured questionnaire was used, with open and closed questions, on socioeconomic, clinical data and aspects related to pharmacotherapy (adverse reactions, drug interactions, systemic blood pressure indexes, fasting glucose values, self-medication practice, overweight, bleeding episodes and thromboembolism). Results: the average age of the participants was 69.1 ± 13.6 years, mostly female (64.6%), married (43.8%), and white (85.4%). As for education, 41.7% attended incomplete elementary school. Polymedicated patients totaled 89.6%, and patients using ten or more medications, 31.3%. The average number of medications per patient was 8.2 ± 3.5. There was an association between polymedication, occurrence of adverse reactions (94.7% vs 5.3%; p = 0.042) and the number of potential drug interactions, total (8.9 ± 5.0 vs 1.2 ± 1.6; p = 0.001) and severe (3.1 ± 2.4 vs 0.4 ± 0.6; p = 0.017). The other variables studied were not associated with polymedication. Conclusion: the results showed negative interference from polymedication in the occurrence of adverse reactions, and in the potential total and serious drug interactions. There is a need to know the impact of these variables on the polymedicated anticoagulated patient to plan risk reduction strategies and to optimize benefits. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer reviewed Avaliado pelos pares artigo original |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900 10.21876/rcshci.v10i2.900 |
url |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900 |
identifier_str_mv |
10.21876/rcshci.v10i2.900 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/900/540 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDE https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDE https://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
AISI/HCI |
publisher.none.fl_str_mv |
AISI/HCI |
dc.source.none.fl_str_mv |
Revista Ciências em Saúde; v. 10 n. 2 (2020): Abril a Junho de 2020; 28-35 Health Sciences Journal; Vol 10 No 2 (2020): April to June 2020; 28-35 2236-3785 10.21876/rcshci.v10i2 reponame:Revista Ciências em Saúde instname:Hospital de Clínicas de Itajubá instacron:HCI |
instname_str |
Hospital de Clínicas de Itajubá |
instacron_str |
HCI |
institution |
HCI |
reponame_str |
Revista Ciências em Saúde |
collection |
Revista Ciências em Saúde |
repository.name.fl_str_mv |
Revista Ciências em Saúde - Hospital de Clínicas de Itajubá |
repository.mail.fl_str_mv |
rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br |
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1797068962714877952 |