Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology

Detalhes bibliográficos
Autor(a) principal: Tambosi,Gabriela
Data de Publicação: 2018
Outros Autores: Coelho,Paola Felippi, Luciano,Soares, Lenschow,Iára Cristina Schmücker, Zétola,Melissa, Stulzer,Hellen Karine, Pezzini,Bianca Ramos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Matéria (Rio de Janeiro. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-70762018000400415
Resumo: ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of the Biopharmaceutics Classification System). One of the most effective strategies to overcome poor dissolution rate and low absorption of drugs is the solid dispersion technique, however, although it has been the focus of much research in recent decades, there are relatively few commercially available products based on such technology. This is mainly due to problems related to production scale-up and physicochemical instability and creates opportunities for new studies to explore the full potential of the technology. This review presents an overall approach to the factors affecting the dissolution rate and oral bioavailability of BCS-classes II and IV drugs and a brief review of the state-of-theart of solid dispersion technology.
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spelling Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technologyoral deliverydrug solubilitydrug dissolutionsolid dispersionABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of the Biopharmaceutics Classification System). One of the most effective strategies to overcome poor dissolution rate and low absorption of drugs is the solid dispersion technique, however, although it has been the focus of much research in recent decades, there are relatively few commercially available products based on such technology. This is mainly due to problems related to production scale-up and physicochemical instability and creates opportunities for new studies to explore the full potential of the technology. This review presents an overall approach to the factors affecting the dissolution rate and oral bioavailability of BCS-classes II and IV drugs and a brief review of the state-of-theart of solid dispersion technology.Laboratório de Hidrogênio, Coppe - Universidade Federal do Rio de Janeiroem cooperação com a Associação Brasileira do Hidrogênio, ABH22018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-70762018000400415Matéria (Rio de Janeiro) v.23 n.4 2018reponame:Matéria (Rio de Janeiro. Online)instname:Matéria (Rio de Janeiro. Online)instacron:RLAM10.1590/s1517-707620180004.0558info:eu-repo/semantics/openAccessTambosi,GabrielaCoelho,Paola FelippiLuciano,SoaresLenschow,Iára Cristina SchmückerZétola,MelissaStulzer,Hellen KarinePezzini,Bianca Ramoseng2018-12-03T00:00:00Zoai:scielo:S1517-70762018000400415Revistahttp://www.materia.coppe.ufrj.br/https://old.scielo.br/oai/scielo-oai.php||materia@labh2.coppe.ufrj.br1517-70761517-7076opendoar:2018-12-03T00:00Matéria (Rio de Janeiro. Online) - Matéria (Rio de Janeiro. Online)false
dc.title.none.fl_str_mv Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
title Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
spellingShingle Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
Tambosi,Gabriela
oral delivery
drug solubility
drug dissolution
solid dispersion
title_short Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
title_full Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
title_fullStr Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
title_full_unstemmed Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
title_sort Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
author Tambosi,Gabriela
author_facet Tambosi,Gabriela
Coelho,Paola Felippi
Luciano,Soares
Lenschow,Iára Cristina Schmücker
Zétola,Melissa
Stulzer,Hellen Karine
Pezzini,Bianca Ramos
author_role author
author2 Coelho,Paola Felippi
Luciano,Soares
Lenschow,Iára Cristina Schmücker
Zétola,Melissa
Stulzer,Hellen Karine
Pezzini,Bianca Ramos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tambosi,Gabriela
Coelho,Paola Felippi
Luciano,Soares
Lenschow,Iára Cristina Schmücker
Zétola,Melissa
Stulzer,Hellen Karine
Pezzini,Bianca Ramos
dc.subject.por.fl_str_mv oral delivery
drug solubility
drug dissolution
solid dispersion
topic oral delivery
drug solubility
drug dissolution
solid dispersion
description ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of the Biopharmaceutics Classification System). One of the most effective strategies to overcome poor dissolution rate and low absorption of drugs is the solid dispersion technique, however, although it has been the focus of much research in recent decades, there are relatively few commercially available products based on such technology. This is mainly due to problems related to production scale-up and physicochemical instability and creates opportunities for new studies to explore the full potential of the technology. This review presents an overall approach to the factors affecting the dissolution rate and oral bioavailability of BCS-classes II and IV drugs and a brief review of the state-of-theart of solid dispersion technology.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-70762018000400415
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-70762018000400415
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1517-707620180004.0558
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Laboratório de Hidrogênio, Coppe - Universidade Federal do Rio de Janeiro
em cooperação com a Associação Brasileira do Hidrogênio, ABH2
publisher.none.fl_str_mv Laboratório de Hidrogênio, Coppe - Universidade Federal do Rio de Janeiro
em cooperação com a Associação Brasileira do Hidrogênio, ABH2
dc.source.none.fl_str_mv Matéria (Rio de Janeiro) v.23 n.4 2018
reponame:Matéria (Rio de Janeiro. Online)
instname:Matéria (Rio de Janeiro. Online)
instacron:RLAM
instname_str Matéria (Rio de Janeiro. Online)
instacron_str RLAM
institution RLAM
reponame_str Matéria (Rio de Janeiro. Online)
collection Matéria (Rio de Janeiro. Online)
repository.name.fl_str_mv Matéria (Rio de Janeiro. Online) - Matéria (Rio de Janeiro. Online)
repository.mail.fl_str_mv ||materia@labh2.coppe.ufrj.br
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