Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Matéria (Rio de Janeiro. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-70762018000400415 |
Resumo: | ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of the Biopharmaceutics Classification System). One of the most effective strategies to overcome poor dissolution rate and low absorption of drugs is the solid dispersion technique, however, although it has been the focus of much research in recent decades, there are relatively few commercially available products based on such technology. This is mainly due to problems related to production scale-up and physicochemical instability and creates opportunities for new studies to explore the full potential of the technology. This review presents an overall approach to the factors affecting the dissolution rate and oral bioavailability of BCS-classes II and IV drugs and a brief review of the state-of-theart of solid dispersion technology. |
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Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technologyoral deliverydrug solubilitydrug dissolutionsolid dispersionABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of the Biopharmaceutics Classification System). One of the most effective strategies to overcome poor dissolution rate and low absorption of drugs is the solid dispersion technique, however, although it has been the focus of much research in recent decades, there are relatively few commercially available products based on such technology. This is mainly due to problems related to production scale-up and physicochemical instability and creates opportunities for new studies to explore the full potential of the technology. This review presents an overall approach to the factors affecting the dissolution rate and oral bioavailability of BCS-classes II and IV drugs and a brief review of the state-of-theart of solid dispersion technology.Laboratório de Hidrogênio, Coppe - Universidade Federal do Rio de Janeiroem cooperação com a Associação Brasileira do Hidrogênio, ABH22018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-70762018000400415Matéria (Rio de Janeiro) v.23 n.4 2018reponame:Matéria (Rio de Janeiro. Online)instname:Matéria (Rio de Janeiro. Online)instacron:RLAM10.1590/s1517-707620180004.0558info:eu-repo/semantics/openAccessTambosi,GabrielaCoelho,Paola FelippiLuciano,SoaresLenschow,Iára Cristina SchmückerZétola,MelissaStulzer,Hellen KarinePezzini,Bianca Ramoseng2018-12-03T00:00:00Zoai:scielo:S1517-70762018000400415Revistahttp://www.materia.coppe.ufrj.br/https://old.scielo.br/oai/scielo-oai.php||materia@labh2.coppe.ufrj.br1517-70761517-7076opendoar:2018-12-03T00:00Matéria (Rio de Janeiro. Online) - Matéria (Rio de Janeiro. Online)false |
dc.title.none.fl_str_mv |
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology |
title |
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology |
spellingShingle |
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology Tambosi,Gabriela oral delivery drug solubility drug dissolution solid dispersion |
title_short |
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology |
title_full |
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology |
title_fullStr |
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology |
title_full_unstemmed |
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology |
title_sort |
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology |
author |
Tambosi,Gabriela |
author_facet |
Tambosi,Gabriela Coelho,Paola Felippi Luciano,Soares Lenschow,Iára Cristina Schmücker Zétola,Melissa Stulzer,Hellen Karine Pezzini,Bianca Ramos |
author_role |
author |
author2 |
Coelho,Paola Felippi Luciano,Soares Lenschow,Iára Cristina Schmücker Zétola,Melissa Stulzer,Hellen Karine Pezzini,Bianca Ramos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Tambosi,Gabriela Coelho,Paola Felippi Luciano,Soares Lenschow,Iára Cristina Schmücker Zétola,Melissa Stulzer,Hellen Karine Pezzini,Bianca Ramos |
dc.subject.por.fl_str_mv |
oral delivery drug solubility drug dissolution solid dispersion |
topic |
oral delivery drug solubility drug dissolution solid dispersion |
description |
ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of the Biopharmaceutics Classification System). One of the most effective strategies to overcome poor dissolution rate and low absorption of drugs is the solid dispersion technique, however, although it has been the focus of much research in recent decades, there are relatively few commercially available products based on such technology. This is mainly due to problems related to production scale-up and physicochemical instability and creates opportunities for new studies to explore the full potential of the technology. This review presents an overall approach to the factors affecting the dissolution rate and oral bioavailability of BCS-classes II and IV drugs and a brief review of the state-of-theart of solid dispersion technology. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-70762018000400415 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-70762018000400415 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1517-707620180004.0558 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Laboratório de Hidrogênio, Coppe - Universidade Federal do Rio de Janeiro em cooperação com a Associação Brasileira do Hidrogênio, ABH2 |
publisher.none.fl_str_mv |
Laboratório de Hidrogênio, Coppe - Universidade Federal do Rio de Janeiro em cooperação com a Associação Brasileira do Hidrogênio, ABH2 |
dc.source.none.fl_str_mv |
Matéria (Rio de Janeiro) v.23 n.4 2018 reponame:Matéria (Rio de Janeiro. Online) instname:Matéria (Rio de Janeiro. Online) instacron:RLAM |
instname_str |
Matéria (Rio de Janeiro. Online) |
instacron_str |
RLAM |
institution |
RLAM |
reponame_str |
Matéria (Rio de Janeiro. Online) |
collection |
Matéria (Rio de Janeiro. Online) |
repository.name.fl_str_mv |
Matéria (Rio de Janeiro. Online) - Matéria (Rio de Janeiro. Online) |
repository.mail.fl_str_mv |
||materia@labh2.coppe.ufrj.br |
_version_ |
1752126691496427520 |