Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam

Detalhes bibliográficos
Autor(a) principal: Neves,Jose Francisco Nunes Pereira das
Data de Publicação: 2016
Outros Autores: Araújo,Mariana Moraes Pereira das Neves, Araújo,Fernando de Paiva, Ferreira,Clarice Martins, Duarte,Fabiana Baeta Neves, Pace,Fabio Heleno, Ornellas,Laura Cotta, Baron,Todd H., Ferreira,Lincoln Eduardo Villela Vieira de Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Anestesiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942016000300231
Resumo: ABSTRACT Colonoscopy is one of the most common procedures. Sedation and analgesia decrease anxiety and discomfort and minimize risks. Therefore, patients prefer to be sedated when undergoing examination, although the best combination of drugs has not been determined. The combination of opioids and benzodiazepines is used to relieve the patient's pain and discomfort. More recently, propofol has assumed a prominent position. This randomized prospective study is unique in medical literature that specifically compared the use of propofol and fentanyl with or without midazolam for colonoscopy sedation performed by anesthesiologists. The aim of this study was to evaluate the side effects of sedation, discharge conditions, quality of sedation, and propofol consumption during colonoscopy, with or without midazolam as preanesthetic. The study involved 140 patients who underwent colonoscopy at the University Hospital of the Federal University of Juiz de Fora. Patients were divided into two groups: Group I received intravenous midazolam as preanesthetic 5 min before sedation, followed by fentanyl and propofol; Group II received intravenous anesthesia with fentanyl and propofol. Patients in Group II had a higher incidence of reaction (motor or verbal) to the colonoscope introduction, bradycardia, hypotension, and increased propofol consumption. Patient satisfaction was higher in Group I. According to the methodology used, the combination of midazolam, fentanyl, and propofol for colonoscopy sedation reduces propofol consumption and provides greater patient satisfaction.
id SBA-1_23da59914409da4427dff895ac04e401
oai_identifier_str oai:scielo:S0034-70942016000300231
network_acronym_str SBA-1
network_name_str Revista Brasileira de Anestesiologia (Online)
repository_id_str
spelling Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolamSedationColonoscopyPropofolFentanilMidazolamABSTRACT Colonoscopy is one of the most common procedures. Sedation and analgesia decrease anxiety and discomfort and minimize risks. Therefore, patients prefer to be sedated when undergoing examination, although the best combination of drugs has not been determined. The combination of opioids and benzodiazepines is used to relieve the patient's pain and discomfort. More recently, propofol has assumed a prominent position. This randomized prospective study is unique in medical literature that specifically compared the use of propofol and fentanyl with or without midazolam for colonoscopy sedation performed by anesthesiologists. The aim of this study was to evaluate the side effects of sedation, discharge conditions, quality of sedation, and propofol consumption during colonoscopy, with or without midazolam as preanesthetic. The study involved 140 patients who underwent colonoscopy at the University Hospital of the Federal University of Juiz de Fora. Patients were divided into two groups: Group I received intravenous midazolam as preanesthetic 5 min before sedation, followed by fentanyl and propofol; Group II received intravenous anesthesia with fentanyl and propofol. Patients in Group II had a higher incidence of reaction (motor or verbal) to the colonoscope introduction, bradycardia, hypotension, and increased propofol consumption. Patient satisfaction was higher in Group I. According to the methodology used, the combination of midazolam, fentanyl, and propofol for colonoscopy sedation reduces propofol consumption and provides greater patient satisfaction.Sociedade Brasileira de Anestesiologia2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942016000300231Revista Brasileira de Anestesiologia v.66 n.3 2016reponame:Revista Brasileira de Anestesiologia (Online)instname:Sociedade Brasileira de Anestesiologia (SBA)instacron:SBA10.1016/j.bjane.2014.09.014info:eu-repo/semantics/openAccessNeves,Jose Francisco Nunes Pereira dasAraújo,Mariana Moraes Pereira das NevesAraújo,Fernando de PaivaFerreira,Clarice MartinsDuarte,Fabiana Baeta NevesPace,Fabio HelenoOrnellas,Laura CottaBaron,Todd H.Ferreira,Lincoln Eduardo Villela Vieira de Castroeng2016-05-30T00:00:00Zoai:scielo:S0034-70942016000300231Revistahttps://www.sbahq.org/revista/https://old.scielo.br/oai/scielo-oai.php||sba2000@openlink.com.br1806-907X0034-7094opendoar:2016-05-30T00:00Revista Brasileira de Anestesiologia (Online) - Sociedade Brasileira de Anestesiologia (SBA)false
dc.title.none.fl_str_mv Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
title Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
spellingShingle Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
Neves,Jose Francisco Nunes Pereira das
Sedation
Colonoscopy
Propofol
Fentanil
Midazolam
title_short Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
title_full Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
title_fullStr Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
title_full_unstemmed Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
title_sort Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
author Neves,Jose Francisco Nunes Pereira das
author_facet Neves,Jose Francisco Nunes Pereira das
Araújo,Mariana Moraes Pereira das Neves
Araújo,Fernando de Paiva
Ferreira,Clarice Martins
Duarte,Fabiana Baeta Neves
Pace,Fabio Heleno
Ornellas,Laura Cotta
Baron,Todd H.
Ferreira,Lincoln Eduardo Villela Vieira de Castro
author_role author
author2 Araújo,Mariana Moraes Pereira das Neves
Araújo,Fernando de Paiva
Ferreira,Clarice Martins
Duarte,Fabiana Baeta Neves
Pace,Fabio Heleno
Ornellas,Laura Cotta
Baron,Todd H.
Ferreira,Lincoln Eduardo Villela Vieira de Castro
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neves,Jose Francisco Nunes Pereira das
Araújo,Mariana Moraes Pereira das Neves
Araújo,Fernando de Paiva
Ferreira,Clarice Martins
Duarte,Fabiana Baeta Neves
Pace,Fabio Heleno
Ornellas,Laura Cotta
Baron,Todd H.
Ferreira,Lincoln Eduardo Villela Vieira de Castro
dc.subject.por.fl_str_mv Sedation
Colonoscopy
Propofol
Fentanil
Midazolam
topic Sedation
Colonoscopy
Propofol
Fentanil
Midazolam
description ABSTRACT Colonoscopy is one of the most common procedures. Sedation and analgesia decrease anxiety and discomfort and minimize risks. Therefore, patients prefer to be sedated when undergoing examination, although the best combination of drugs has not been determined. The combination of opioids and benzodiazepines is used to relieve the patient's pain and discomfort. More recently, propofol has assumed a prominent position. This randomized prospective study is unique in medical literature that specifically compared the use of propofol and fentanyl with or without midazolam for colonoscopy sedation performed by anesthesiologists. The aim of this study was to evaluate the side effects of sedation, discharge conditions, quality of sedation, and propofol consumption during colonoscopy, with or without midazolam as preanesthetic. The study involved 140 patients who underwent colonoscopy at the University Hospital of the Federal University of Juiz de Fora. Patients were divided into two groups: Group I received intravenous midazolam as preanesthetic 5 min before sedation, followed by fentanyl and propofol; Group II received intravenous anesthesia with fentanyl and propofol. Patients in Group II had a higher incidence of reaction (motor or verbal) to the colonoscope introduction, bradycardia, hypotension, and increased propofol consumption. Patient satisfaction was higher in Group I. According to the methodology used, the combination of midazolam, fentanyl, and propofol for colonoscopy sedation reduces propofol consumption and provides greater patient satisfaction.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942016000300231
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942016000300231
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjane.2014.09.014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Anestesiologia
publisher.none.fl_str_mv Sociedade Brasileira de Anestesiologia
dc.source.none.fl_str_mv Revista Brasileira de Anestesiologia v.66 n.3 2016
reponame:Revista Brasileira de Anestesiologia (Online)
instname:Sociedade Brasileira de Anestesiologia (SBA)
instacron:SBA
instname_str Sociedade Brasileira de Anestesiologia (SBA)
instacron_str SBA
institution SBA
reponame_str Revista Brasileira de Anestesiologia (Online)
collection Revista Brasileira de Anestesiologia (Online)
repository.name.fl_str_mv Revista Brasileira de Anestesiologia (Online) - Sociedade Brasileira de Anestesiologia (SBA)
repository.mail.fl_str_mv ||sba2000@openlink.com.br
_version_ 1752126628676239360