Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Anestesiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942017000200193 |
Resumo: | Abstract Background and objectives: Sevoflurane is often used in pediatric anesthesia and is associated with high incidence of psychomotor agitation. In such cases, dexmedetomidine (DEX) has been used, but its benefit and implications remain uncertain. We assessed the effects of DEX on agitation in children undergoing general anesthesia with sevoflurane. Method: Meta-analysis of randomized clinical and double-blind studies, with children undergoing elective procedures under general anesthesia with sevoflurane, using DEX or placebo. We sought articles in English in PubMed database using the following terms: Dexmedetomidine, sevoflurane (Methyl Ethers/sevoflurante), and agitation (Psychomotor Agitation). Duplicate articles with children who received premedication and used active control were excluded. It was adopted random effects model with DerSimonian-Laird testing and odds ratio (OR) calculation for dichotomous variables, and standardized mean difference for continuous variables, with their respective 95% confidence interval (CI). Results: Of 146 studies identified, 10 were selected totaling 558 patients (282 in DEX group and 276 controls). The use of DEX was considered a protective factor for psychomotor agitation (OR = 0.17; 95% CI 0.13-0.23; p < 0.0001) and nausea and vomiting in PACU (OR = 0.49; 95% CI 0.35-0.68; p < 0.0001). Wake-up time and PACU discharge time were higher in the dexmedetomidine group. There was no difference between groups for extubation time and duration of anesthesia. Conclusion: Dexmedetomidine reduces psychomotor agitation during wake-up time of children undergoing general anesthesia with sevoflurane. |
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Revista Brasileira de Anestesiologia (Online) |
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Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysisGeneral anesthesiaInhalational anestheticsDexmedetomidinePsychomotor agitationMeta-analysisAbstract Background and objectives: Sevoflurane is often used in pediatric anesthesia and is associated with high incidence of psychomotor agitation. In such cases, dexmedetomidine (DEX) has been used, but its benefit and implications remain uncertain. We assessed the effects of DEX on agitation in children undergoing general anesthesia with sevoflurane. Method: Meta-analysis of randomized clinical and double-blind studies, with children undergoing elective procedures under general anesthesia with sevoflurane, using DEX or placebo. We sought articles in English in PubMed database using the following terms: Dexmedetomidine, sevoflurane (Methyl Ethers/sevoflurante), and agitation (Psychomotor Agitation). Duplicate articles with children who received premedication and used active control were excluded. It was adopted random effects model with DerSimonian-Laird testing and odds ratio (OR) calculation for dichotomous variables, and standardized mean difference for continuous variables, with their respective 95% confidence interval (CI). Results: Of 146 studies identified, 10 were selected totaling 558 patients (282 in DEX group and 276 controls). The use of DEX was considered a protective factor for psychomotor agitation (OR = 0.17; 95% CI 0.13-0.23; p < 0.0001) and nausea and vomiting in PACU (OR = 0.49; 95% CI 0.35-0.68; p < 0.0001). Wake-up time and PACU discharge time were higher in the dexmedetomidine group. There was no difference between groups for extubation time and duration of anesthesia. Conclusion: Dexmedetomidine reduces psychomotor agitation during wake-up time of children undergoing general anesthesia with sevoflurane.Sociedade Brasileira de Anestesiologia2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942017000200193Revista Brasileira de Anestesiologia v.67 n.2 2017reponame:Revista Brasileira de Anestesiologia (Online)instname:Sociedade Brasileira de Anestesiologia (SBA)instacron:SBA10.1016/j.bjane.2016.02.007info:eu-repo/semantics/openAccessAmorim,Marco Aurélio SoaresGovêia,Catia SousaMagalhães,EdnoLadeira,Luís Cláudio AraújoMoreira,Larissa GovêiaMiranda,Denismar Borges deeng2017-03-22T00:00:00Zoai:scielo:S0034-70942017000200193Revistahttps://www.sbahq.org/revista/https://old.scielo.br/oai/scielo-oai.php||sba2000@openlink.com.br1806-907X0034-7094opendoar:2017-03-22T00:00Revista Brasileira de Anestesiologia (Online) - Sociedade Brasileira de Anestesiologia (SBA)false |
dc.title.none.fl_str_mv |
Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis |
title |
Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis |
spellingShingle |
Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis Amorim,Marco Aurélio Soares General anesthesia Inhalational anesthetics Dexmedetomidine Psychomotor agitation Meta-analysis |
title_short |
Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis |
title_full |
Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis |
title_fullStr |
Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis |
title_full_unstemmed |
Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis |
title_sort |
Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis |
author |
Amorim,Marco Aurélio Soares |
author_facet |
Amorim,Marco Aurélio Soares Govêia,Catia Sousa Magalhães,Edno Ladeira,Luís Cláudio Araújo Moreira,Larissa Govêia Miranda,Denismar Borges de |
author_role |
author |
author2 |
Govêia,Catia Sousa Magalhães,Edno Ladeira,Luís Cláudio Araújo Moreira,Larissa Govêia Miranda,Denismar Borges de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Amorim,Marco Aurélio Soares Govêia,Catia Sousa Magalhães,Edno Ladeira,Luís Cláudio Araújo Moreira,Larissa Govêia Miranda,Denismar Borges de |
dc.subject.por.fl_str_mv |
General anesthesia Inhalational anesthetics Dexmedetomidine Psychomotor agitation Meta-analysis |
topic |
General anesthesia Inhalational anesthetics Dexmedetomidine Psychomotor agitation Meta-analysis |
description |
Abstract Background and objectives: Sevoflurane is often used in pediatric anesthesia and is associated with high incidence of psychomotor agitation. In such cases, dexmedetomidine (DEX) has been used, but its benefit and implications remain uncertain. We assessed the effects of DEX on agitation in children undergoing general anesthesia with sevoflurane. Method: Meta-analysis of randomized clinical and double-blind studies, with children undergoing elective procedures under general anesthesia with sevoflurane, using DEX or placebo. We sought articles in English in PubMed database using the following terms: Dexmedetomidine, sevoflurane (Methyl Ethers/sevoflurante), and agitation (Psychomotor Agitation). Duplicate articles with children who received premedication and used active control were excluded. It was adopted random effects model with DerSimonian-Laird testing and odds ratio (OR) calculation for dichotomous variables, and standardized mean difference for continuous variables, with their respective 95% confidence interval (CI). Results: Of 146 studies identified, 10 were selected totaling 558 patients (282 in DEX group and 276 controls). The use of DEX was considered a protective factor for psychomotor agitation (OR = 0.17; 95% CI 0.13-0.23; p < 0.0001) and nausea and vomiting in PACU (OR = 0.49; 95% CI 0.35-0.68; p < 0.0001). Wake-up time and PACU discharge time were higher in the dexmedetomidine group. There was no difference between groups for extubation time and duration of anesthesia. Conclusion: Dexmedetomidine reduces psychomotor agitation during wake-up time of children undergoing general anesthesia with sevoflurane. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942017000200193 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942017000200193 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjane.2016.02.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Anestesiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Anestesiologia |
dc.source.none.fl_str_mv |
Revista Brasileira de Anestesiologia v.67 n.2 2017 reponame:Revista Brasileira de Anestesiologia (Online) instname:Sociedade Brasileira de Anestesiologia (SBA) instacron:SBA |
instname_str |
Sociedade Brasileira de Anestesiologia (SBA) |
instacron_str |
SBA |
institution |
SBA |
reponame_str |
Revista Brasileira de Anestesiologia (Online) |
collection |
Revista Brasileira de Anestesiologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Anestesiologia (Online) - Sociedade Brasileira de Anestesiologia (SBA) |
repository.mail.fl_str_mv |
||sba2000@openlink.com.br |
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1752126629108252672 |