Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression

Detalhes bibliográficos
Autor(a) principal: Masson,Walter
Data de Publicação: 2015
Outros Autores: Siniawski,Daniel, Lobo,Martín, Molinero,Graciela, Giorgi,Mariano, Huerín,Melina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015002000011
Resumo: Background:Previous reports have inferred a linear relationship between LDL-C and changes in coronary plaque volume (CPV) measured by intravascular ultrasound. However, these publications included a small number of studies and did not explore other lipid markers.Objective:To assess the association between changes in lipid markers and regression of CPV using published data.Methods:We collected data from the control, placebo and intervention arms in studies that compared the effect of lipidlowering treatments on CPV, and from the placebo and control arms in studies that tested drugs that did not affect lipids. Baseline and final measurements of plaque volume, expressed in mm3, were extracted and the percentage changes after the interventions were calculated. Performing three linear regression analyses, we assessed the relationship between percentage and absolute changes in lipid markers and percentage variations in CPV.Results:Twenty-seven studies were selected. Correlations between percentage changes in LDL-C, non-HDL-C, and apolipoprotein B (ApoB) and percentage changes in CPV were moderate (r = 0.48, r = 0.47, and r = 0.44, respectively). Correlations between absolute differences in LDL-C, non‑HDL-C, and ApoB with percentage differences in CPV were stronger (r = 0.57, r = 0.52, and r = 0.79). The linear regression model showed a statistically significant association between a reduction in lipid markers and regression of plaque volume.Conclusion:A significant association between changes in different atherogenic particles and regression of CPV was observed. The absolute reduction in ApoB showed the strongest correlation with coronary plaque regression.
id SBC-1_34634da7f46234d6d27e644024f824f6
oai_identifier_str oai:scielo:S0066-782X2015002000011
network_acronym_str SBC-1
network_name_str Arquivos Brasileiros de Cardiologia (Online)
repository_id_str
spelling Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque RegressionCardiovascular DiseasesAtherosclerosis / physiopathologyCholesterol, LDLApolipoprotein B/ therapeutic useLipoproteins, LDLBackground:Previous reports have inferred a linear relationship between LDL-C and changes in coronary plaque volume (CPV) measured by intravascular ultrasound. However, these publications included a small number of studies and did not explore other lipid markers.Objective:To assess the association between changes in lipid markers and regression of CPV using published data.Methods:We collected data from the control, placebo and intervention arms in studies that compared the effect of lipidlowering treatments on CPV, and from the placebo and control arms in studies that tested drugs that did not affect lipids. Baseline and final measurements of plaque volume, expressed in mm3, were extracted and the percentage changes after the interventions were calculated. Performing three linear regression analyses, we assessed the relationship between percentage and absolute changes in lipid markers and percentage variations in CPV.Results:Twenty-seven studies were selected. Correlations between percentage changes in LDL-C, non-HDL-C, and apolipoprotein B (ApoB) and percentage changes in CPV were moderate (r = 0.48, r = 0.47, and r = 0.44, respectively). Correlations between absolute differences in LDL-C, non‑HDL-C, and ApoB with percentage differences in CPV were stronger (r = 0.57, r = 0.52, and r = 0.79). The linear regression model showed a statistically significant association between a reduction in lipid markers and regression of plaque volume.Conclusion:A significant association between changes in different atherogenic particles and regression of CPV was observed. The absolute reduction in ApoB showed the strongest correlation with coronary plaque regression.Sociedade Brasileira de Cardiologia - SBC2015-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015002000011Arquivos Brasileiros de Cardiologia v.105 n.1 2015reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20150050info:eu-repo/semantics/openAccessMasson,WalterSiniawski,DanielLobo,MartínMolinero,GracielaGiorgi,MarianoHuerín,Melinaeng2015-10-19T00:00:00Zoai:scielo:S0066-782X2015002000011Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2015-10-19T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
title Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
spellingShingle Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
Masson,Walter
Cardiovascular Diseases
Atherosclerosis / physiopathology
Cholesterol, LDL
Apolipoprotein B/ therapeutic use
Lipoproteins, LDL
title_short Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
title_full Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
title_fullStr Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
title_full_unstemmed Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
title_sort Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
author Masson,Walter
author_facet Masson,Walter
Siniawski,Daniel
Lobo,Martín
Molinero,Graciela
Giorgi,Mariano
Huerín,Melina
author_role author
author2 Siniawski,Daniel
Lobo,Martín
Molinero,Graciela
Giorgi,Mariano
Huerín,Melina
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Masson,Walter
Siniawski,Daniel
Lobo,Martín
Molinero,Graciela
Giorgi,Mariano
Huerín,Melina
dc.subject.por.fl_str_mv Cardiovascular Diseases
Atherosclerosis / physiopathology
Cholesterol, LDL
Apolipoprotein B/ therapeutic use
Lipoproteins, LDL
topic Cardiovascular Diseases
Atherosclerosis / physiopathology
Cholesterol, LDL
Apolipoprotein B/ therapeutic use
Lipoproteins, LDL
description Background:Previous reports have inferred a linear relationship between LDL-C and changes in coronary plaque volume (CPV) measured by intravascular ultrasound. However, these publications included a small number of studies and did not explore other lipid markers.Objective:To assess the association between changes in lipid markers and regression of CPV using published data.Methods:We collected data from the control, placebo and intervention arms in studies that compared the effect of lipidlowering treatments on CPV, and from the placebo and control arms in studies that tested drugs that did not affect lipids. Baseline and final measurements of plaque volume, expressed in mm3, were extracted and the percentage changes after the interventions were calculated. Performing three linear regression analyses, we assessed the relationship between percentage and absolute changes in lipid markers and percentage variations in CPV.Results:Twenty-seven studies were selected. Correlations between percentage changes in LDL-C, non-HDL-C, and apolipoprotein B (ApoB) and percentage changes in CPV were moderate (r = 0.48, r = 0.47, and r = 0.44, respectively). Correlations between absolute differences in LDL-C, non‑HDL-C, and ApoB with percentage differences in CPV were stronger (r = 0.57, r = 0.52, and r = 0.79). The linear regression model showed a statistically significant association between a reduction in lipid markers and regression of plaque volume.Conclusion:A significant association between changes in different atherogenic particles and regression of CPV was observed. The absolute reduction in ApoB showed the strongest correlation with coronary plaque regression.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015002000011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015002000011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20150050
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.105 n.1 2015
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
instacron_str SBC
institution SBC
reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
_version_ 1752126565653676032

Registros relacionados