Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline

Detalhes bibliográficos
Autor(a) principal: Almeida,André Luiz Cerqueira de
Data de Publicação: 2015
Outros Autores: Silva,Viviane Almeida, Souza Filho,Alberto Teófilo de, Rios,Vinicius Guedes, Lopes,João Ricardo Pinto, Afonseca,Samuel Oliveira de, Cunha,Daniel de Castro Araújo, Mendes,Murilo Oliveira da Cunha, Miranda,Danilo Leal, Santos Júnior,Edval Gomes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400003
Resumo: Background: Heart failure is a severe complication associated with doxorubicin (DOX) use. Strain, assessed by two-dimensional speckle tracking (2D-STE), has been shown to be useful in identifying subclinical ventricular dysfunction. Objectives: a) To investigate the role of strain in the identification of subclinical ventricular dysfunction in patients who used DOX; b) to investigate determinants of strain response in these patients. Methods: Cross-sectional study with 81 participants: 40 patients who used DOX ±2 years before the study and 41 controls. All participants had left ventricular ejection fraction (LVEF) ≥55%. Total dose of DOX was 396mg (242mg/ms2). The systolic function of the LV was evaluated by LVEF (Simpson), as well as by longitudinal (εLL), circumferential (εCC), and radial (εRR) strains. Multivariate linear regression (MLR) analysis was performed using εLL (model 1) and εCC (model 2) as dependent variables. Results: Systolic and diastolic blood pressure values were higher in the control group (p < 0.05). εLL was lower in the DOX group (-12.4 ±2.6%) versus controls (-13.4 ± 1.7%; p = 0.044). The same occurred with εCC: -12.1 ± 2.7% (DOX) versus -16.7 ± 3.6% (controls; p < 0.001). The S’ wave was shorter in the DOX group (p = 0.035). On MLR, DOX was an independent predictor of reduced εCC (B = -4.429, p < 0.001). DOX (B = -1.289, p = 0.012) and age (B = -0.057, p = 0.029) were independent markers of reduced εLL. Conclusion: a) εLL, εCC and the S’ wave are reduced in patients who used DOX ±2 years prior to the study despite normal LVEF, suggesting the presence of subclinical ventricular dysfunction; b) DOX was an independent predictor of reduced εCC; c) prior use of DOX and age were independent markers of reduced εLL.
id SBC-1_5d2b736948768578b8ce77e15803eb87
oai_identifier_str oai:scielo:S0066-782X2015000400003
network_acronym_str SBC-1
network_name_str Arquivos Brasileiros de Cardiologia (Online)
repository_id_str
spelling Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of AnthracyclineHeart FailureVentricular Dysfunction Left / chemically inducedEchocardiographyAnthracyclines / adverse effects Background: Heart failure is a severe complication associated with doxorubicin (DOX) use. Strain, assessed by two-dimensional speckle tracking (2D-STE), has been shown to be useful in identifying subclinical ventricular dysfunction. Objectives: a) To investigate the role of strain in the identification of subclinical ventricular dysfunction in patients who used DOX; b) to investigate determinants of strain response in these patients. Methods: Cross-sectional study with 81 participants: 40 patients who used DOX ±2 years before the study and 41 controls. All participants had left ventricular ejection fraction (LVEF) ≥55%. Total dose of DOX was 396mg (242mg/ms2). The systolic function of the LV was evaluated by LVEF (Simpson), as well as by longitudinal (εLL), circumferential (εCC), and radial (εRR) strains. Multivariate linear regression (MLR) analysis was performed using εLL (model 1) and εCC (model 2) as dependent variables. Results: Systolic and diastolic blood pressure values were higher in the control group (p < 0.05). εLL was lower in the DOX group (-12.4 ±2.6%) versus controls (-13.4 ± 1.7%; p = 0.044). The same occurred with εCC: -12.1 ± 2.7% (DOX) versus -16.7 ± 3.6% (controls; p < 0.001). The S’ wave was shorter in the DOX group (p = 0.035). On MLR, DOX was an independent predictor of reduced εCC (B = -4.429, p < 0.001). DOX (B = -1.289, p = 0.012) and age (B = -0.057, p = 0.029) were independent markers of reduced εLL. Conclusion: a) εLL, εCC and the S’ wave are reduced in patients who used DOX ±2 years prior to the study despite normal LVEF, suggesting the presence of subclinical ventricular dysfunction; b) DOX was an independent predictor of reduced εCC; c) prior use of DOX and age were independent markers of reduced εLL. Sociedade Brasileira de Cardiologia - SBC2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400003Arquivos Brasileiros de Cardiologia v.104 n.4 2015reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20140209info:eu-repo/semantics/openAccessAlmeida,André Luiz Cerqueira deSilva,Viviane AlmeidaSouza Filho,Alberto Teófilo deRios,Vinicius GuedesLopes,João Ricardo PintoAfonseca,Samuel Oliveira deCunha,Daniel de Castro AraújoMendes,Murilo Oliveira da CunhaMiranda,Danilo LealSantos Júnior,Edval Gomes doseng2015-05-06T00:00:00Zoai:scielo:S0066-782X2015000400003Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2015-05-06T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
title Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
spellingShingle Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
Almeida,André Luiz Cerqueira de
Heart Failure
Ventricular Dysfunction Left / chemically induced
Echocardiography
Anthracyclines / adverse effects
title_short Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
title_full Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
title_fullStr Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
title_full_unstemmed Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
title_sort Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
author Almeida,André Luiz Cerqueira de
author_facet Almeida,André Luiz Cerqueira de
Silva,Viviane Almeida
Souza Filho,Alberto Teófilo de
Rios,Vinicius Guedes
Lopes,João Ricardo Pinto
Afonseca,Samuel Oliveira de
Cunha,Daniel de Castro Araújo
Mendes,Murilo Oliveira da Cunha
Miranda,Danilo Leal
Santos Júnior,Edval Gomes dos
author_role author
author2 Silva,Viviane Almeida
Souza Filho,Alberto Teófilo de
Rios,Vinicius Guedes
Lopes,João Ricardo Pinto
Afonseca,Samuel Oliveira de
Cunha,Daniel de Castro Araújo
Mendes,Murilo Oliveira da Cunha
Miranda,Danilo Leal
Santos Júnior,Edval Gomes dos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida,André Luiz Cerqueira de
Silva,Viviane Almeida
Souza Filho,Alberto Teófilo de
Rios,Vinicius Guedes
Lopes,João Ricardo Pinto
Afonseca,Samuel Oliveira de
Cunha,Daniel de Castro Araújo
Mendes,Murilo Oliveira da Cunha
Miranda,Danilo Leal
Santos Júnior,Edval Gomes dos
dc.subject.por.fl_str_mv Heart Failure
Ventricular Dysfunction Left / chemically induced
Echocardiography
Anthracyclines / adverse effects
topic Heart Failure
Ventricular Dysfunction Left / chemically induced
Echocardiography
Anthracyclines / adverse effects
description Background: Heart failure is a severe complication associated with doxorubicin (DOX) use. Strain, assessed by two-dimensional speckle tracking (2D-STE), has been shown to be useful in identifying subclinical ventricular dysfunction. Objectives: a) To investigate the role of strain in the identification of subclinical ventricular dysfunction in patients who used DOX; b) to investigate determinants of strain response in these patients. Methods: Cross-sectional study with 81 participants: 40 patients who used DOX ±2 years before the study and 41 controls. All participants had left ventricular ejection fraction (LVEF) ≥55%. Total dose of DOX was 396mg (242mg/ms2). The systolic function of the LV was evaluated by LVEF (Simpson), as well as by longitudinal (εLL), circumferential (εCC), and radial (εRR) strains. Multivariate linear regression (MLR) analysis was performed using εLL (model 1) and εCC (model 2) as dependent variables. Results: Systolic and diastolic blood pressure values were higher in the control group (p < 0.05). εLL was lower in the DOX group (-12.4 ±2.6%) versus controls (-13.4 ± 1.7%; p = 0.044). The same occurred with εCC: -12.1 ± 2.7% (DOX) versus -16.7 ± 3.6% (controls; p < 0.001). The S’ wave was shorter in the DOX group (p = 0.035). On MLR, DOX was an independent predictor of reduced εCC (B = -4.429, p < 0.001). DOX (B = -1.289, p = 0.012) and age (B = -0.057, p = 0.029) were independent markers of reduced εLL. Conclusion: a) εLL, εCC and the S’ wave are reduced in patients who used DOX ±2 years prior to the study despite normal LVEF, suggesting the presence of subclinical ventricular dysfunction; b) DOX was an independent predictor of reduced εCC; c) prior use of DOX and age were independent markers of reduced εLL.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20140209
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.104 n.4 2015
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
instacron_str SBC
institution SBC
reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
_version_ 1752126564869341184