Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400003 |
Resumo: | Background: Heart failure is a severe complication associated with doxorubicin (DOX) use. Strain, assessed by two-dimensional speckle tracking (2D-STE), has been shown to be useful in identifying subclinical ventricular dysfunction. Objectives: a) To investigate the role of strain in the identification of subclinical ventricular dysfunction in patients who used DOX; b) to investigate determinants of strain response in these patients. Methods: Cross-sectional study with 81 participants: 40 patients who used DOX ±2 years before the study and 41 controls. All participants had left ventricular ejection fraction (LVEF) ≥55%. Total dose of DOX was 396mg (242mg/ms2). The systolic function of the LV was evaluated by LVEF (Simpson), as well as by longitudinal (εLL), circumferential (εCC), and radial (εRR) strains. Multivariate linear regression (MLR) analysis was performed using εLL (model 1) and εCC (model 2) as dependent variables. Results: Systolic and diastolic blood pressure values were higher in the control group (p < 0.05). εLL was lower in the DOX group (-12.4 ±2.6%) versus controls (-13.4 ± 1.7%; p = 0.044). The same occurred with εCC: -12.1 ± 2.7% (DOX) versus -16.7 ± 3.6% (controls; p < 0.001). The S’ wave was shorter in the DOX group (p = 0.035). On MLR, DOX was an independent predictor of reduced εCC (B = -4.429, p < 0.001). DOX (B = -1.289, p = 0.012) and age (B = -0.057, p = 0.029) were independent markers of reduced εLL. Conclusion: a) εLL, εCC and the S’ wave are reduced in patients who used DOX ±2 years prior to the study despite normal LVEF, suggesting the presence of subclinical ventricular dysfunction; b) DOX was an independent predictor of reduced εCC; c) prior use of DOX and age were independent markers of reduced εLL. |
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Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of AnthracyclineHeart FailureVentricular Dysfunction Left / chemically inducedEchocardiographyAnthracyclines / adverse effects Background: Heart failure is a severe complication associated with doxorubicin (DOX) use. Strain, assessed by two-dimensional speckle tracking (2D-STE), has been shown to be useful in identifying subclinical ventricular dysfunction. Objectives: a) To investigate the role of strain in the identification of subclinical ventricular dysfunction in patients who used DOX; b) to investigate determinants of strain response in these patients. Methods: Cross-sectional study with 81 participants: 40 patients who used DOX ±2 years before the study and 41 controls. All participants had left ventricular ejection fraction (LVEF) ≥55%. Total dose of DOX was 396mg (242mg/ms2). The systolic function of the LV was evaluated by LVEF (Simpson), as well as by longitudinal (εLL), circumferential (εCC), and radial (εRR) strains. Multivariate linear regression (MLR) analysis was performed using εLL (model 1) and εCC (model 2) as dependent variables. Results: Systolic and diastolic blood pressure values were higher in the control group (p < 0.05). εLL was lower in the DOX group (-12.4 ±2.6%) versus controls (-13.4 ± 1.7%; p = 0.044). The same occurred with εCC: -12.1 ± 2.7% (DOX) versus -16.7 ± 3.6% (controls; p < 0.001). The S’ wave was shorter in the DOX group (p = 0.035). On MLR, DOX was an independent predictor of reduced εCC (B = -4.429, p < 0.001). DOX (B = -1.289, p = 0.012) and age (B = -0.057, p = 0.029) were independent markers of reduced εLL. Conclusion: a) εLL, εCC and the S’ wave are reduced in patients who used DOX ±2 years prior to the study despite normal LVEF, suggesting the presence of subclinical ventricular dysfunction; b) DOX was an independent predictor of reduced εCC; c) prior use of DOX and age were independent markers of reduced εLL. Sociedade Brasileira de Cardiologia - SBC2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400003Arquivos Brasileiros de Cardiologia v.104 n.4 2015reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20140209info:eu-repo/semantics/openAccessAlmeida,André Luiz Cerqueira deSilva,Viviane AlmeidaSouza Filho,Alberto Teófilo deRios,Vinicius GuedesLopes,João Ricardo PintoAfonseca,Samuel Oliveira deCunha,Daniel de Castro AraújoMendes,Murilo Oliveira da CunhaMiranda,Danilo LealSantos Júnior,Edval Gomes doseng2015-05-06T00:00:00Zoai:scielo:S0066-782X2015000400003Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2015-05-06T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline |
title |
Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline |
spellingShingle |
Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline Almeida,André Luiz Cerqueira de Heart Failure Ventricular Dysfunction Left / chemically induced Echocardiography Anthracyclines / adverse effects |
title_short |
Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline |
title_full |
Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline |
title_fullStr |
Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline |
title_full_unstemmed |
Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline |
title_sort |
Subclinical Ventricular Dysfunction Detected by Speckle Tracking Two Years after Use of Anthracycline |
author |
Almeida,André Luiz Cerqueira de |
author_facet |
Almeida,André Luiz Cerqueira de Silva,Viviane Almeida Souza Filho,Alberto Teófilo de Rios,Vinicius Guedes Lopes,João Ricardo Pinto Afonseca,Samuel Oliveira de Cunha,Daniel de Castro Araújo Mendes,Murilo Oliveira da Cunha Miranda,Danilo Leal Santos Júnior,Edval Gomes dos |
author_role |
author |
author2 |
Silva,Viviane Almeida Souza Filho,Alberto Teófilo de Rios,Vinicius Guedes Lopes,João Ricardo Pinto Afonseca,Samuel Oliveira de Cunha,Daniel de Castro Araújo Mendes,Murilo Oliveira da Cunha Miranda,Danilo Leal Santos Júnior,Edval Gomes dos |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Almeida,André Luiz Cerqueira de Silva,Viviane Almeida Souza Filho,Alberto Teófilo de Rios,Vinicius Guedes Lopes,João Ricardo Pinto Afonseca,Samuel Oliveira de Cunha,Daniel de Castro Araújo Mendes,Murilo Oliveira da Cunha Miranda,Danilo Leal Santos Júnior,Edval Gomes dos |
dc.subject.por.fl_str_mv |
Heart Failure Ventricular Dysfunction Left / chemically induced Echocardiography Anthracyclines / adverse effects |
topic |
Heart Failure Ventricular Dysfunction Left / chemically induced Echocardiography Anthracyclines / adverse effects |
description |
Background: Heart failure is a severe complication associated with doxorubicin (DOX) use. Strain, assessed by two-dimensional speckle tracking (2D-STE), has been shown to be useful in identifying subclinical ventricular dysfunction. Objectives: a) To investigate the role of strain in the identification of subclinical ventricular dysfunction in patients who used DOX; b) to investigate determinants of strain response in these patients. Methods: Cross-sectional study with 81 participants: 40 patients who used DOX ±2 years before the study and 41 controls. All participants had left ventricular ejection fraction (LVEF) ≥55%. Total dose of DOX was 396mg (242mg/ms2). The systolic function of the LV was evaluated by LVEF (Simpson), as well as by longitudinal (εLL), circumferential (εCC), and radial (εRR) strains. Multivariate linear regression (MLR) analysis was performed using εLL (model 1) and εCC (model 2) as dependent variables. Results: Systolic and diastolic blood pressure values were higher in the control group (p < 0.05). εLL was lower in the DOX group (-12.4 ±2.6%) versus controls (-13.4 ± 1.7%; p = 0.044). The same occurred with εCC: -12.1 ± 2.7% (DOX) versus -16.7 ± 3.6% (controls; p < 0.001). The S’ wave was shorter in the DOX group (p = 0.035). On MLR, DOX was an independent predictor of reduced εCC (B = -4.429, p < 0.001). DOX (B = -1.289, p = 0.012) and age (B = -0.057, p = 0.029) were independent markers of reduced εLL. Conclusion: a) εLL, εCC and the S’ wave are reduced in patients who used DOX ±2 years prior to the study despite normal LVEF, suggesting the presence of subclinical ventricular dysfunction; b) DOX was an independent predictor of reduced εCC; c) prior use of DOX and age were independent markers of reduced εLL. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000400003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/abc.20140209 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.104 n.4 2015 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
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1752126564869341184 |