Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences

Detalhes bibliográficos
Autor(a) principal: Odozynski,Gabriel
Data de Publicação: 2018
Outros Autores: Forno,Alexander Romeno Janner Dal, Lewandowski,Andrei, Nascimento,Hélcio Garcia, d'Avila,André
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000500449
Resumo: Abstract Background: The catheter ablation of atrial fibrillation (AF) is performed less frequently in women. In addition, there is divergent information in the literature regarding the effectiveness and safety for the ablative procedure to females. Objectives: The objective of this study was to compare the clinical characteristics and outcomes in men and women undergoing paroxysmal atrial fibrillation (PAF) ablation. Methods: Cohort study of patients undergoing first-ever PAF catheter ablation procedure refractory to antiarrhythmic drugs. The information was taken from patients’ records by means of a digital collection instrument and indexed to an online database (Syscardio®). Clinical characteristics and procedures were compared between each gender (M x F), adopting a level of statistical significance of 5%. The primary endpoint associated with efficacy was freedom from atrial arrhythmia over the follow-up time. Results: 225 patients were included in the study, 64 (29%) women and 161 (71%) men. Women presented more symptoms due to AF according to the CCS-SAF score (1.8 ± 0.8M x 2.3 ± 0.8F p = 0.02) and higher CHADS2 score compared to men (0.9 ± 0.8M x 1.2 ± 1F). Post-ablation recurrence occurred in 20% of the patients, with no difference based on gender (21% M x 20% F p = 0.52). The rate of complications was less than 3% for both groups (p = 0.98). Conclusion: Women undergoing the first-ever PAF catheter ablation procedure present similar complication rate and clinical outcome compared to men. These findings suggest that the current underutilization of AF catheter ablation in women may represent a discrepancy in care.
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spelling Paroxysmal Atrial Fibrillation in Females: Understanding gender diferencesArrhythmias,CardiacAtrial FibrillationCatheter AblationCardiac ElectrophysiologyGenderAbstract Background: The catheter ablation of atrial fibrillation (AF) is performed less frequently in women. In addition, there is divergent information in the literature regarding the effectiveness and safety for the ablative procedure to females. Objectives: The objective of this study was to compare the clinical characteristics and outcomes in men and women undergoing paroxysmal atrial fibrillation (PAF) ablation. Methods: Cohort study of patients undergoing first-ever PAF catheter ablation procedure refractory to antiarrhythmic drugs. The information was taken from patients’ records by means of a digital collection instrument and indexed to an online database (Syscardio®). Clinical characteristics and procedures were compared between each gender (M x F), adopting a level of statistical significance of 5%. The primary endpoint associated with efficacy was freedom from atrial arrhythmia over the follow-up time. Results: 225 patients were included in the study, 64 (29%) women and 161 (71%) men. Women presented more symptoms due to AF according to the CCS-SAF score (1.8 ± 0.8M x 2.3 ± 0.8F p = 0.02) and higher CHADS2 score compared to men (0.9 ± 0.8M x 1.2 ± 1F). Post-ablation recurrence occurred in 20% of the patients, with no difference based on gender (21% M x 20% F p = 0.52). The rate of complications was less than 3% for both groups (p = 0.98). Conclusion: Women undergoing the first-ever PAF catheter ablation procedure present similar complication rate and clinical outcome compared to men. These findings suggest that the current underutilization of AF catheter ablation in women may represent a discrepancy in care.Sociedade Brasileira de Cardiologia - SBC2018-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000500449Arquivos Brasileiros de Cardiologia v.110 n.5 2018reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20180069info:eu-repo/semantics/openAccessOdozynski,GabrielForno,Alexander Romeno Janner DalLewandowski,AndreiNascimento,Hélcio Garciad'Avila,Andréeng2018-05-30T00:00:00Zoai:scielo:S0066-782X2018000500449Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2018-05-30T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences
title Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences
spellingShingle Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences
Odozynski,Gabriel
Arrhythmias,Cardiac
Atrial Fibrillation
Catheter Ablation
Cardiac Electrophysiology
Gender
title_short Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences
title_full Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences
title_fullStr Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences
title_full_unstemmed Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences
title_sort Paroxysmal Atrial Fibrillation in Females: Understanding gender diferences
author Odozynski,Gabriel
author_facet Odozynski,Gabriel
Forno,Alexander Romeno Janner Dal
Lewandowski,Andrei
Nascimento,Hélcio Garcia
d'Avila,André
author_role author
author2 Forno,Alexander Romeno Janner Dal
Lewandowski,Andrei
Nascimento,Hélcio Garcia
d'Avila,André
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Odozynski,Gabriel
Forno,Alexander Romeno Janner Dal
Lewandowski,Andrei
Nascimento,Hélcio Garcia
d'Avila,André
dc.subject.por.fl_str_mv Arrhythmias,Cardiac
Atrial Fibrillation
Catheter Ablation
Cardiac Electrophysiology
Gender
topic Arrhythmias,Cardiac
Atrial Fibrillation
Catheter Ablation
Cardiac Electrophysiology
Gender
description Abstract Background: The catheter ablation of atrial fibrillation (AF) is performed less frequently in women. In addition, there is divergent information in the literature regarding the effectiveness and safety for the ablative procedure to females. Objectives: The objective of this study was to compare the clinical characteristics and outcomes in men and women undergoing paroxysmal atrial fibrillation (PAF) ablation. Methods: Cohort study of patients undergoing first-ever PAF catheter ablation procedure refractory to antiarrhythmic drugs. The information was taken from patients’ records by means of a digital collection instrument and indexed to an online database (Syscardio®). Clinical characteristics and procedures were compared between each gender (M x F), adopting a level of statistical significance of 5%. The primary endpoint associated with efficacy was freedom from atrial arrhythmia over the follow-up time. Results: 225 patients were included in the study, 64 (29%) women and 161 (71%) men. Women presented more symptoms due to AF according to the CCS-SAF score (1.8 ± 0.8M x 2.3 ± 0.8F p = 0.02) and higher CHADS2 score compared to men (0.9 ± 0.8M x 1.2 ± 1F). Post-ablation recurrence occurred in 20% of the patients, with no difference based on gender (21% M x 20% F p = 0.52). The rate of complications was less than 3% for both groups (p = 0.98). Conclusion: Women undergoing the first-ever PAF catheter ablation procedure present similar complication rate and clinical outcome compared to men. These findings suggest that the current underutilization of AF catheter ablation in women may represent a discrepancy in care.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000500449
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20180069
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.110 n.5 2018
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
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institution SBC
reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
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