Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002 |
Resumo: | OBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of tolerance to exercise, the other two after administration of placebo or 45mg of PYR). RESULTS: Heart rate at rest was: 68±3 vs 68±3bpm before and after placebo, respectively (P=0.38); 70±2 vs 59±2bpm, before and after pyridostigmine, respectively (P<0.01). During exercise, relative to placebo: a significantly lower heart rate after PYR at, respectively, 20% (P=0.02), 40% (P=0.03), 80% (P=0.05) and 100% (P=0.02) of peak effort was observed. No significant differences were observed in arterial blood pressure, oxygen consumption at submaximal and maximal effort, exercise duration, respiratory ratio, CO2 production, ventilation threshold, minute ventilation, and oxygen pulse. CONCLUSION: Pyridostigmine, at a dose of 45mg, decreases heart rate at rest and during exercise, with minimal side effects and without interfering with exercise tolerance and ventilation variables. |
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Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmineautonomic nervous systempyridostigmineexercise stress testingOBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of tolerance to exercise, the other two after administration of placebo or 45mg of PYR). RESULTS: Heart rate at rest was: 68±3 vs 68±3bpm before and after placebo, respectively (P=0.38); 70±2 vs 59±2bpm, before and after pyridostigmine, respectively (P<0.01). During exercise, relative to placebo: a significantly lower heart rate after PYR at, respectively, 20% (P=0.02), 40% (P=0.03), 80% (P=0.05) and 100% (P=0.02) of peak effort was observed. No significant differences were observed in arterial blood pressure, oxygen consumption at submaximal and maximal effort, exercise duration, respiratory ratio, CO2 production, ventilation threshold, minute ventilation, and oxygen pulse. CONCLUSION: Pyridostigmine, at a dose of 45mg, decreases heart rate at rest and during exercise, with minimal side effects and without interfering with exercise tolerance and ventilation variables.Sociedade Brasileira de Cardiologia - SBC2001-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002Arquivos Brasileiros de Cardiologia v.76 n.4 2001reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.1590/S0066-782X2001000400002info:eu-repo/semantics/openAccessSerra,Salvador M.Costa,Ricardo Vivacqua C.Bastos,Bianca GouvêaSantos,Kelb BousquetRamalho,Sérgio Henrique RodolphoNóbrega,Antonio Claudio Lucas daeng2002-01-08T00:00:00Zoai:scielo:S0066-782X2001000400002Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2002-01-08T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
spellingShingle |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine Serra,Salvador M. autonomic nervous system pyridostigmine exercise stress testing |
title_short |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_full |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_fullStr |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_full_unstemmed |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_sort |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
author |
Serra,Salvador M. |
author_facet |
Serra,Salvador M. Costa,Ricardo Vivacqua C. Bastos,Bianca Gouvêa Santos,Kelb Bousquet Ramalho,Sérgio Henrique Rodolpho Nóbrega,Antonio Claudio Lucas da |
author_role |
author |
author2 |
Costa,Ricardo Vivacqua C. Bastos,Bianca Gouvêa Santos,Kelb Bousquet Ramalho,Sérgio Henrique Rodolpho Nóbrega,Antonio Claudio Lucas da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Serra,Salvador M. Costa,Ricardo Vivacqua C. Bastos,Bianca Gouvêa Santos,Kelb Bousquet Ramalho,Sérgio Henrique Rodolpho Nóbrega,Antonio Claudio Lucas da |
dc.subject.por.fl_str_mv |
autonomic nervous system pyridostigmine exercise stress testing |
topic |
autonomic nervous system pyridostigmine exercise stress testing |
description |
OBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of tolerance to exercise, the other two after administration of placebo or 45mg of PYR). RESULTS: Heart rate at rest was: 68±3 vs 68±3bpm before and after placebo, respectively (P=0.38); 70±2 vs 59±2bpm, before and after pyridostigmine, respectively (P<0.01). During exercise, relative to placebo: a significantly lower heart rate after PYR at, respectively, 20% (P=0.02), 40% (P=0.03), 80% (P=0.05) and 100% (P=0.02) of peak effort was observed. No significant differences were observed in arterial blood pressure, oxygen consumption at submaximal and maximal effort, exercise duration, respiratory ratio, CO2 production, ventilation threshold, minute ventilation, and oxygen pulse. CONCLUSION: Pyridostigmine, at a dose of 45mg, decreases heart rate at rest and during exercise, with minimal side effects and without interfering with exercise tolerance and ventilation variables. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0066-782X2001000400002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.76 n.4 2001 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
_version_ |
1752126551626874880 |