Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016000100056 |
Resumo: | Abstract Background: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. Objective: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. Methods: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Results: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Conclusion: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients. |
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Arquivos Brasileiros de Cardiologia (Online) |
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Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular EventsAtherosclerosisCoronary Artery DiseaseBlood SedimentationFibrinogenCardiovascular Diseases / adverse eventsAbstract Background: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. Objective: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. Methods: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Results: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Conclusion: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients.Sociedade Brasileira de Cardiologia - SBC2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016000100056Arquivos Brasileiros de Cardiologia v.106 n.1 2016reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20150146info:eu-repo/semantics/openAccessCho,Sung WooKim,Byung GyuKim,Byung OkByun,Young SupGoh,Choong WonRhee,Kun JooKwon,Hyuck MoonLee,Byoung Kwoneng2016-01-22T00:00:00Zoai:scielo:S0066-782X2016000100056Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2016-01-22T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events |
title |
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events |
spellingShingle |
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events Cho,Sung Woo Atherosclerosis Coronary Artery Disease Blood Sedimentation Fibrinogen Cardiovascular Diseases / adverse events |
title_short |
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events |
title_full |
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events |
title_fullStr |
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events |
title_full_unstemmed |
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events |
title_sort |
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events |
author |
Cho,Sung Woo |
author_facet |
Cho,Sung Woo Kim,Byung Gyu Kim,Byung Ok Byun,Young Sup Goh,Choong Won Rhee,Kun Joo Kwon,Hyuck Moon Lee,Byoung Kwon |
author_role |
author |
author2 |
Kim,Byung Gyu Kim,Byung Ok Byun,Young Sup Goh,Choong Won Rhee,Kun Joo Kwon,Hyuck Moon Lee,Byoung Kwon |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Cho,Sung Woo Kim,Byung Gyu Kim,Byung Ok Byun,Young Sup Goh,Choong Won Rhee,Kun Joo Kwon,Hyuck Moon Lee,Byoung Kwon |
dc.subject.por.fl_str_mv |
Atherosclerosis Coronary Artery Disease Blood Sedimentation Fibrinogen Cardiovascular Diseases / adverse events |
topic |
Atherosclerosis Coronary Artery Disease Blood Sedimentation Fibrinogen Cardiovascular Diseases / adverse events |
description |
Abstract Background: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. Objective: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. Methods: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Results: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Conclusion: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016000100056 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016000100056 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/abc.20150146 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.106 n.1 2016 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
_version_ |
1752126565759582208 |