Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease

Detalhes bibliográficos
Autor(a) principal: Montazerifar,Farzaneh
Data de Publicação: 2016
Outros Autores: Bolouri,Ahmad, Paghalea,Raheleh Sharifian, Mahani,Mahbubeh Khodadadpour, Karajibani,Mansour
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004300348
Resumo: Abstract Background: Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases. Objective: The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD). Methods: In a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity. Results: CAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found. Conclusions: The findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results.
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spelling Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery DiseaseCoronary Artery DiseaseObesityResistinLeptinAtherosclerosisAbstract Background: Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases. Objective: The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD). Methods: In a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity. Results: CAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found. Conclusions: The findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results.Sociedade Brasileira de Cardiologia - SBC2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004300348Arquivos Brasileiros de Cardiologia v.107 n.4 2016reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20160134info:eu-repo/semantics/openAccessMontazerifar,FarzanehBolouri,AhmadPaghalea,Raheleh SharifianMahani,Mahbubeh KhodadadpourKarajibani,Mansoureng2016-11-09T00:00:00Zoai:scielo:S0066-782X2016004300348Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2016-11-09T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
spellingShingle Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
Montazerifar,Farzaneh
Coronary Artery Disease
Obesity
Resistin
Leptin
Atherosclerosis
title_short Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_full Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_fullStr Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_full_unstemmed Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_sort Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
author Montazerifar,Farzaneh
author_facet Montazerifar,Farzaneh
Bolouri,Ahmad
Paghalea,Raheleh Sharifian
Mahani,Mahbubeh Khodadadpour
Karajibani,Mansour
author_role author
author2 Bolouri,Ahmad
Paghalea,Raheleh Sharifian
Mahani,Mahbubeh Khodadadpour
Karajibani,Mansour
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Montazerifar,Farzaneh
Bolouri,Ahmad
Paghalea,Raheleh Sharifian
Mahani,Mahbubeh Khodadadpour
Karajibani,Mansour
dc.subject.por.fl_str_mv Coronary Artery Disease
Obesity
Resistin
Leptin
Atherosclerosis
topic Coronary Artery Disease
Obesity
Resistin
Leptin
Atherosclerosis
description Abstract Background: Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases. Objective: The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD). Methods: In a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity. Results: CAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found. Conclusions: The findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004300348
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004300348
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20160134
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.107 n.4 2016
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
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reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
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