Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia

Detalhes bibliográficos
Autor(a) principal: Menti,Eduardo
Data de Publicação: 2016
Outros Autores: Zaffari,Denise, Galarraga,Thais, Lessa,João Regis da Conceição e, Pontin,Bruna, Pellanda,Lucia Campos, Portal,Vera Lúcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016000600457
Resumo: Abstract Background: Excessive weight is a cardiovascular risk factor since it generates a chronic inflammatory process that aggravates the endothelial function. Objective: To evaluate the endothelial function in individuals with excess weight and mild dyslipidemia using brachial artery flow-mediated dilation (BAFMD), and the association of endothelial function with anthropometric and biochemical variables. Methods: Cross-sectional study that included 74 individuals and evaluated anthropometric variables (body mass index [BMI], waist-hip ratio [WHR], waist circumference [AC], and percentage of body fat [PBF]), biochemical (blood glucose, insulinemia, ultrasensitive C-reactive protein, fibrinogen, total cholesterol, HDL-cholesterol, triglycerides, and LDL-cholesterol) and endothelial function (BAFMD, evaluated by ultrasound). The statistical analysis was performed with SPSS, version 16.0. To study the association between the variables, we used chi-square, Student's t and Mann-Whitney tests, and Pearson's correlation. Logistic regression analyzed the independent influence of the factors. Values of p < 0.05 were considered significant. Results: The participants had a mean age of 50.8 years, and 57% were female. BMI, WC, WHR, and PBF showed no significant association with BAFMD. The male gender (p = 0.02) and higher serum levels of fibrinogen (p = 0.02) were significantly and independently associated with a BAFMD below 8%. Conclusions: In individuals with excess weight and mild untreated dyslipidemia, male gender and higher levels of fibrinogen were independently associated with worse BAFMD.
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spelling Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and DyslipidemiaAtherosclerosisBiomarkersEndotheliumObesityDyslipidemiasAbstract Background: Excessive weight is a cardiovascular risk factor since it generates a chronic inflammatory process that aggravates the endothelial function. Objective: To evaluate the endothelial function in individuals with excess weight and mild dyslipidemia using brachial artery flow-mediated dilation (BAFMD), and the association of endothelial function with anthropometric and biochemical variables. Methods: Cross-sectional study that included 74 individuals and evaluated anthropometric variables (body mass index [BMI], waist-hip ratio [WHR], waist circumference [AC], and percentage of body fat [PBF]), biochemical (blood glucose, insulinemia, ultrasensitive C-reactive protein, fibrinogen, total cholesterol, HDL-cholesterol, triglycerides, and LDL-cholesterol) and endothelial function (BAFMD, evaluated by ultrasound). The statistical analysis was performed with SPSS, version 16.0. To study the association between the variables, we used chi-square, Student's t and Mann-Whitney tests, and Pearson's correlation. Logistic regression analyzed the independent influence of the factors. Values of p < 0.05 were considered significant. Results: The participants had a mean age of 50.8 years, and 57% were female. BMI, WC, WHR, and PBF showed no significant association with BAFMD. The male gender (p = 0.02) and higher serum levels of fibrinogen (p = 0.02) were significantly and independently associated with a BAFMD below 8%. Conclusions: In individuals with excess weight and mild untreated dyslipidemia, male gender and higher levels of fibrinogen were independently associated with worse BAFMD.Sociedade Brasileira de Cardiologia - SBC2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016000600457Arquivos Brasileiros de Cardiologia v.106 n.6 2016reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20160060info:eu-repo/semantics/openAccessMenti,EduardoZaffari,DeniseGalarraga,ThaisLessa,João Regis da Conceição ePontin,BrunaPellanda,Lucia CamposPortal,Vera Lúciaeng2016-07-08T00:00:00Zoai:scielo:S0066-782X2016000600457Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2016-07-08T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia
title Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia
spellingShingle Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia
Menti,Eduardo
Atherosclerosis
Biomarkers
Endothelium
Obesity
Dyslipidemias
title_short Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia
title_full Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia
title_fullStr Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia
title_full_unstemmed Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia
title_sort Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia
author Menti,Eduardo
author_facet Menti,Eduardo
Zaffari,Denise
Galarraga,Thais
Lessa,João Regis da Conceição e
Pontin,Bruna
Pellanda,Lucia Campos
Portal,Vera Lúcia
author_role author
author2 Zaffari,Denise
Galarraga,Thais
Lessa,João Regis da Conceição e
Pontin,Bruna
Pellanda,Lucia Campos
Portal,Vera Lúcia
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Menti,Eduardo
Zaffari,Denise
Galarraga,Thais
Lessa,João Regis da Conceição e
Pontin,Bruna
Pellanda,Lucia Campos
Portal,Vera Lúcia
dc.subject.por.fl_str_mv Atherosclerosis
Biomarkers
Endothelium
Obesity
Dyslipidemias
topic Atherosclerosis
Biomarkers
Endothelium
Obesity
Dyslipidemias
description Abstract Background: Excessive weight is a cardiovascular risk factor since it generates a chronic inflammatory process that aggravates the endothelial function. Objective: To evaluate the endothelial function in individuals with excess weight and mild dyslipidemia using brachial artery flow-mediated dilation (BAFMD), and the association of endothelial function with anthropometric and biochemical variables. Methods: Cross-sectional study that included 74 individuals and evaluated anthropometric variables (body mass index [BMI], waist-hip ratio [WHR], waist circumference [AC], and percentage of body fat [PBF]), biochemical (blood glucose, insulinemia, ultrasensitive C-reactive protein, fibrinogen, total cholesterol, HDL-cholesterol, triglycerides, and LDL-cholesterol) and endothelial function (BAFMD, evaluated by ultrasound). The statistical analysis was performed with SPSS, version 16.0. To study the association between the variables, we used chi-square, Student's t and Mann-Whitney tests, and Pearson's correlation. Logistic regression analyzed the independent influence of the factors. Values of p < 0.05 were considered significant. Results: The participants had a mean age of 50.8 years, and 57% were female. BMI, WC, WHR, and PBF showed no significant association with BAFMD. The male gender (p = 0.02) and higher serum levels of fibrinogen (p = 0.02) were significantly and independently associated with a BAFMD below 8%. Conclusions: In individuals with excess weight and mild untreated dyslipidemia, male gender and higher levels of fibrinogen were independently associated with worse BAFMD.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016000600457
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20160060
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.106 n.6 2016
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
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reponame_str Arquivos Brasileiros de Cardiologia (Online)
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repository.mail.fl_str_mv ||arquivos@cardiol.br
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