Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000600739 |
Resumo: | Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction < 40%. All patients underwent a maximal cardiopulmonary exercise testing. Maximal heart rate was recorded and delta heart rate recovery (∆HRR) was assessed at 1st and 2nd minutes after exercise. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Dual-energy X-ray absorptiometry was used to measure body composition and sarcopenia was defined by the sum of appendicular lean muscle mass (ALM) divided by height in meters squared and handgrip strength. Results: Sarcopenia was identified in 33 patients (28%). Patients with sarcopenia had higher MSNA than those without (47 [41-52] vs. 40 [34-48] bursts/min, p = 0.028). Sarcopenic patients showed lower ∆HRR at 1st (15 [10-21] vs. 22 [16-30] beats/min, p < 0.001) and 2nd min (25 [19-39] vs. 35 [24-48] beats/min, p = 0.017) than non-sarcopenic. There was a positive correlation between ALM and ∆HRR at 1st (r = 0.26, p = 0.008) and 2nd min (r = 0.25, p = 0.012). We observed a negative correlation between ALM and MSNA (r = -0.29, p = 0.003). Conclusion: Sympatho-vagal imbalance seems to be associated with sarcopenia in male patients with HF. These results highlight the importance of a therapeutic approach in patients with muscle wasting and increased peripheral sympathetic outflow. |
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Arquivos Brasileiros de Cardiologia (Online) |
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Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart FailureHeart FailureSarcopeniaSympathetic HyperactivityBlunted Vagal Reactivation.Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction < 40%. All patients underwent a maximal cardiopulmonary exercise testing. Maximal heart rate was recorded and delta heart rate recovery (∆HRR) was assessed at 1st and 2nd minutes after exercise. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Dual-energy X-ray absorptiometry was used to measure body composition and sarcopenia was defined by the sum of appendicular lean muscle mass (ALM) divided by height in meters squared and handgrip strength. Results: Sarcopenia was identified in 33 patients (28%). Patients with sarcopenia had higher MSNA than those without (47 [41-52] vs. 40 [34-48] bursts/min, p = 0.028). Sarcopenic patients showed lower ∆HRR at 1st (15 [10-21] vs. 22 [16-30] beats/min, p < 0.001) and 2nd min (25 [19-39] vs. 35 [24-48] beats/min, p = 0.017) than non-sarcopenic. There was a positive correlation between ALM and ∆HRR at 1st (r = 0.26, p = 0.008) and 2nd min (r = 0.25, p = 0.012). We observed a negative correlation between ALM and MSNA (r = -0.29, p = 0.003). Conclusion: Sympatho-vagal imbalance seems to be associated with sarcopenia in male patients with HF. These results highlight the importance of a therapeutic approach in patients with muscle wasting and increased peripheral sympathetic outflow.Sociedade Brasileira de Cardiologia - SBC2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000600739Arquivos Brasileiros de Cardiologia v.112 n.6 2019reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20190061info:eu-repo/semantics/openAccessFonseca,Guilherme Wesley Peixoto daSantos,Marcelo Rodrigues dosSouza,Francis Ribeiro deCosta,Marcel Jose A. daHaehling,Stephan vonTakayama,LiliamPereira,Rosa Maria R.Negrão,Carlos EduardoAnker,Stefan D.Alves,Maria Janieire de Nazaré Nuneseng2019-07-31T00:00:00Zoai:scielo:S0066-782X2019000600739Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2019-07-31T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure |
title |
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure |
spellingShingle |
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure Fonseca,Guilherme Wesley Peixoto da Heart Failure Sarcopenia Sympathetic Hyperactivity Blunted Vagal Reactivation. |
title_short |
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure |
title_full |
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure |
title_fullStr |
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure |
title_full_unstemmed |
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure |
title_sort |
Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure |
author |
Fonseca,Guilherme Wesley Peixoto da |
author_facet |
Fonseca,Guilherme Wesley Peixoto da Santos,Marcelo Rodrigues dos Souza,Francis Ribeiro de Costa,Marcel Jose A. da Haehling,Stephan von Takayama,Liliam Pereira,Rosa Maria R. Negrão,Carlos Eduardo Anker,Stefan D. Alves,Maria Janieire de Nazaré Nunes |
author_role |
author |
author2 |
Santos,Marcelo Rodrigues dos Souza,Francis Ribeiro de Costa,Marcel Jose A. da Haehling,Stephan von Takayama,Liliam Pereira,Rosa Maria R. Negrão,Carlos Eduardo Anker,Stefan D. Alves,Maria Janieire de Nazaré Nunes |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fonseca,Guilherme Wesley Peixoto da Santos,Marcelo Rodrigues dos Souza,Francis Ribeiro de Costa,Marcel Jose A. da Haehling,Stephan von Takayama,Liliam Pereira,Rosa Maria R. Negrão,Carlos Eduardo Anker,Stefan D. Alves,Maria Janieire de Nazaré Nunes |
dc.subject.por.fl_str_mv |
Heart Failure Sarcopenia Sympathetic Hyperactivity Blunted Vagal Reactivation. |
topic |
Heart Failure Sarcopenia Sympathetic Hyperactivity Blunted Vagal Reactivation. |
description |
Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction < 40%. All patients underwent a maximal cardiopulmonary exercise testing. Maximal heart rate was recorded and delta heart rate recovery (∆HRR) was assessed at 1st and 2nd minutes after exercise. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Dual-energy X-ray absorptiometry was used to measure body composition and sarcopenia was defined by the sum of appendicular lean muscle mass (ALM) divided by height in meters squared and handgrip strength. Results: Sarcopenia was identified in 33 patients (28%). Patients with sarcopenia had higher MSNA than those without (47 [41-52] vs. 40 [34-48] bursts/min, p = 0.028). Sarcopenic patients showed lower ∆HRR at 1st (15 [10-21] vs. 22 [16-30] beats/min, p < 0.001) and 2nd min (25 [19-39] vs. 35 [24-48] beats/min, p = 0.017) than non-sarcopenic. There was a positive correlation between ALM and ∆HRR at 1st (r = 0.26, p = 0.008) and 2nd min (r = 0.25, p = 0.012). We observed a negative correlation between ALM and MSNA (r = -0.29, p = 0.003). Conclusion: Sympatho-vagal imbalance seems to be associated with sarcopenia in male patients with HF. These results highlight the importance of a therapeutic approach in patients with muscle wasting and increased peripheral sympathetic outflow. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000600739 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000600739 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/abc.20190061 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.112 n.6 2019 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
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1752126569775628288 |