Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography

Detalhes bibliográficos
Autor(a) principal: Camargo,Gabriel Cordeiro
Data de Publicação: 2017
Outros Autores: Rothstein,Tamara, Derenne,Maria Eduarda, Sabioni,Leticia, Lima,João A. C., Lima,Ronaldo de Souza Leão, Gottlieb,Ilan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000500396
Resumo: Abstract Background: Coronary computed tomography angiography (CCTA) allows for noninvasive coronary artery disease (CAD) phenotyping. Factors related to CAD progression are epidemiologically valuable. Objective: To identify factors associated with CAD progression in patients undergoing sequential CCTA testing. Methods: We retrospectively analyzed 384 consecutive patients who had at least two CCTA studies between December 2005 and March 2013. Due to limitations in the quantification of CAD progression, we excluded patients who had undergone surgical revascularization previously or percutaneous coronary intervention (PCI) between studies. CAD progression was defined as any increase in the adapted segment stenosis score (calculated using the number of diseased segments and stenosis severity) in all coronary segments without stent (in-stent restenosis was excluded from the analysis). Stepwise logistic regression was used to assess variables associated with CAD progression. Results: From a final population of 234 patients, a total of 117 (50%) had CAD progression. In a model accounting for major CAD risk factors and other baseline characteristics, only age (odds ratio [OR] 1.04, 95% confidence interval [95%CI] 1.01-1.07), interstudy interval (OR 1.03, 95%CI 1.01-1.04), and past PCI (OR 3.66, 95%CI 1.77-7.55) showed an independent relationship with CAD progression. Conclusions: A history of PCI with stent placement was independently associated with a 3.7-fold increase in the odds of CAD progression, excluding in-stent restenosis. Age and interstudy interval were also independent predictors of progression.
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spelling Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography AngiographyCoronary Artery Disease/physiopathologyCoronary AmgiographyTomography, X-Ray ComputedPercutaneous Coronary InterventionAbstract Background: Coronary computed tomography angiography (CCTA) allows for noninvasive coronary artery disease (CAD) phenotyping. Factors related to CAD progression are epidemiologically valuable. Objective: To identify factors associated with CAD progression in patients undergoing sequential CCTA testing. Methods: We retrospectively analyzed 384 consecutive patients who had at least two CCTA studies between December 2005 and March 2013. Due to limitations in the quantification of CAD progression, we excluded patients who had undergone surgical revascularization previously or percutaneous coronary intervention (PCI) between studies. CAD progression was defined as any increase in the adapted segment stenosis score (calculated using the number of diseased segments and stenosis severity) in all coronary segments without stent (in-stent restenosis was excluded from the analysis). Stepwise logistic regression was used to assess variables associated with CAD progression. Results: From a final population of 234 patients, a total of 117 (50%) had CAD progression. In a model accounting for major CAD risk factors and other baseline characteristics, only age (odds ratio [OR] 1.04, 95% confidence interval [95%CI] 1.01-1.07), interstudy interval (OR 1.03, 95%CI 1.01-1.04), and past PCI (OR 3.66, 95%CI 1.77-7.55) showed an independent relationship with CAD progression. Conclusions: A history of PCI with stent placement was independently associated with a 3.7-fold increase in the odds of CAD progression, excluding in-stent restenosis. Age and interstudy interval were also independent predictors of progression.Sociedade Brasileira de Cardiologia - SBC2017-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000500396Arquivos Brasileiros de Cardiologia v.108 n.5 2017reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20170049info:eu-repo/semantics/openAccessCamargo,Gabriel CordeiroRothstein,TamaraDerenne,Maria EduardaSabioni,LeticiaLima,João A. C.Lima,Ronaldo de Souza LeãoGottlieb,Ilaneng2017-07-05T00:00:00Zoai:scielo:S0066-782X2017000500396Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2017-07-05T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
title Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
spellingShingle Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
Camargo,Gabriel Cordeiro
Coronary Artery Disease/physiopathology
Coronary Amgiography
Tomography, X-Ray Computed
Percutaneous Coronary Intervention
title_short Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
title_full Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
title_fullStr Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
title_full_unstemmed Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
title_sort Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography
author Camargo,Gabriel Cordeiro
author_facet Camargo,Gabriel Cordeiro
Rothstein,Tamara
Derenne,Maria Eduarda
Sabioni,Leticia
Lima,João A. C.
Lima,Ronaldo de Souza Leão
Gottlieb,Ilan
author_role author
author2 Rothstein,Tamara
Derenne,Maria Eduarda
Sabioni,Leticia
Lima,João A. C.
Lima,Ronaldo de Souza Leão
Gottlieb,Ilan
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Camargo,Gabriel Cordeiro
Rothstein,Tamara
Derenne,Maria Eduarda
Sabioni,Leticia
Lima,João A. C.
Lima,Ronaldo de Souza Leão
Gottlieb,Ilan
dc.subject.por.fl_str_mv Coronary Artery Disease/physiopathology
Coronary Amgiography
Tomography, X-Ray Computed
Percutaneous Coronary Intervention
topic Coronary Artery Disease/physiopathology
Coronary Amgiography
Tomography, X-Ray Computed
Percutaneous Coronary Intervention
description Abstract Background: Coronary computed tomography angiography (CCTA) allows for noninvasive coronary artery disease (CAD) phenotyping. Factors related to CAD progression are epidemiologically valuable. Objective: To identify factors associated with CAD progression in patients undergoing sequential CCTA testing. Methods: We retrospectively analyzed 384 consecutive patients who had at least two CCTA studies between December 2005 and March 2013. Due to limitations in the quantification of CAD progression, we excluded patients who had undergone surgical revascularization previously or percutaneous coronary intervention (PCI) between studies. CAD progression was defined as any increase in the adapted segment stenosis score (calculated using the number of diseased segments and stenosis severity) in all coronary segments without stent (in-stent restenosis was excluded from the analysis). Stepwise logistic regression was used to assess variables associated with CAD progression. Results: From a final population of 234 patients, a total of 117 (50%) had CAD progression. In a model accounting for major CAD risk factors and other baseline characteristics, only age (odds ratio [OR] 1.04, 95% confidence interval [95%CI] 1.01-1.07), interstudy interval (OR 1.03, 95%CI 1.01-1.04), and past PCI (OR 3.66, 95%CI 1.77-7.55) showed an independent relationship with CAD progression. Conclusions: A history of PCI with stent placement was independently associated with a 3.7-fold increase in the odds of CAD progression, excluding in-stent restenosis. Age and interstudy interval were also independent predictors of progression.
publishDate 2017
dc.date.none.fl_str_mv 2017-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.relation.none.fl_str_mv 10.5935/abc.20170049
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.108 n.5 2017
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
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instname_str Sociedade Brasileira de Cardiologia (SBC)
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reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
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repository.mail.fl_str_mv ||arquivos@cardiol.br
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