DD Genotype and Atherosclerosis in Overweight Menopausal Women

Detalhes bibliográficos
Autor(a) principal: Lanz-Luces,José Ramón
Data de Publicação: 2021
Outros Autores: Costa,Fernando Alves, Guzman,Luis Fernando Escobar, Gagliardi,Antonio Ricardo de Toledo, Lanz-Luces,José Antonio, Lanz-Souquett,José Daniel, Costa,Leandro Menezes Alves da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Journal of Cardiovascular Sciences (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021000400411
Resumo: Abstract Background Sex-specific pathology of coronary artery disease (CAD) has not been recognized. Women with obstructive or nonobstructive CAD associated with traditional risk factors have similar events; no studies have explored both populations in association with genetic markers. Objective To evaluate the DD genotype in overweight menopausal women and its association with CAD and traditional risk factors. Method This cross-sectional study included 356 menopausal women who underwent coronary angiography as CAD assessment. The patients’ DNA was extracted and polymorphisms were detected with a single polymerase chain reaction assay. Two groups were formed based on luminal lesions (normal [n = 134] or pathological [n = 222]) with a cutoff value > 30%, considering overweight and age. The chi-square test, Student’s t-test, and multivariate logistic regression were performed as appropriate (p < 0.05) using the following variables: overweight, diabetes, hypertension, dyslipidemia, smoking status, sedentary lifestyle, and a family history of CAD. Results The mean age of the sample was 63 + 8 years, and the mean BMI was 28 + 5 kg/m2. The DD genotype was slightly more prevalent in the pathological group (30.2% vs. 21.6%, p = 0.079), but this significantly changed when BMI > 25 was considered (33% vs. 18%, p = 0.012). In multivariate analysis with two threshold levels (> 50 and > 60 years), diabetes was significantly associated with CAD in both models (p = 0.021 vs. 0.009) but the genotype was only associated with younger age (p = 0.034). Conclusion These data support an association between atherosclerosis and the renin–angiotensin system in overweight menopausal women that is dependent on the age at which the ischemic event occurs.
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spelling DD Genotype and Atherosclerosis in Overweight Menopausal WomenOverweightMenopauseCoronary Artery DiseaseGenetic MarkersDD GenotypeAbstract Background Sex-specific pathology of coronary artery disease (CAD) has not been recognized. Women with obstructive or nonobstructive CAD associated with traditional risk factors have similar events; no studies have explored both populations in association with genetic markers. Objective To evaluate the DD genotype in overweight menopausal women and its association with CAD and traditional risk factors. Method This cross-sectional study included 356 menopausal women who underwent coronary angiography as CAD assessment. The patients’ DNA was extracted and polymorphisms were detected with a single polymerase chain reaction assay. Two groups were formed based on luminal lesions (normal [n = 134] or pathological [n = 222]) with a cutoff value > 30%, considering overweight and age. The chi-square test, Student’s t-test, and multivariate logistic regression were performed as appropriate (p < 0.05) using the following variables: overweight, diabetes, hypertension, dyslipidemia, smoking status, sedentary lifestyle, and a family history of CAD. Results The mean age of the sample was 63 + 8 years, and the mean BMI was 28 + 5 kg/m2. The DD genotype was slightly more prevalent in the pathological group (30.2% vs. 21.6%, p = 0.079), but this significantly changed when BMI > 25 was considered (33% vs. 18%, p = 0.012). In multivariate analysis with two threshold levels (> 50 and > 60 years), diabetes was significantly associated with CAD in both models (p = 0.021 vs. 0.009) but the genotype was only associated with younger age (p = 0.034). Conclusion These data support an association between atherosclerosis and the renin–angiotensin system in overweight menopausal women that is dependent on the age at which the ischemic event occurs.Sociedade Brasileira de Cardiologia2021-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021000400411International Journal of Cardiovascular Sciences v.34 n.4 2021reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.36660/ijcs.20200400info:eu-repo/semantics/openAccessLanz-Luces,José RamónCosta,Fernando AlvesGuzman,Luis Fernando EscobarGagliardi,Antonio Ricardo de ToledoLanz-Luces,José AntonioLanz-Souquett,José DanielCosta,Leandro Menezes Alves daeng2022-02-02T00:00:00Zoai:scielo:S2359-56472021000400411Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2022-02-02T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv DD Genotype and Atherosclerosis in Overweight Menopausal Women
title DD Genotype and Atherosclerosis in Overweight Menopausal Women
spellingShingle DD Genotype and Atherosclerosis in Overweight Menopausal Women
Lanz-Luces,José Ramón
Overweight
Menopause
Coronary Artery Disease
Genetic Markers
DD Genotype
title_short DD Genotype and Atherosclerosis in Overweight Menopausal Women
title_full DD Genotype and Atherosclerosis in Overweight Menopausal Women
title_fullStr DD Genotype and Atherosclerosis in Overweight Menopausal Women
title_full_unstemmed DD Genotype and Atherosclerosis in Overweight Menopausal Women
title_sort DD Genotype and Atherosclerosis in Overweight Menopausal Women
author Lanz-Luces,José Ramón
author_facet Lanz-Luces,José Ramón
Costa,Fernando Alves
Guzman,Luis Fernando Escobar
Gagliardi,Antonio Ricardo de Toledo
Lanz-Luces,José Antonio
Lanz-Souquett,José Daniel
Costa,Leandro Menezes Alves da
author_role author
author2 Costa,Fernando Alves
Guzman,Luis Fernando Escobar
Gagliardi,Antonio Ricardo de Toledo
Lanz-Luces,José Antonio
Lanz-Souquett,José Daniel
Costa,Leandro Menezes Alves da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lanz-Luces,José Ramón
Costa,Fernando Alves
Guzman,Luis Fernando Escobar
Gagliardi,Antonio Ricardo de Toledo
Lanz-Luces,José Antonio
Lanz-Souquett,José Daniel
Costa,Leandro Menezes Alves da
dc.subject.por.fl_str_mv Overweight
Menopause
Coronary Artery Disease
Genetic Markers
DD Genotype
topic Overweight
Menopause
Coronary Artery Disease
Genetic Markers
DD Genotype
description Abstract Background Sex-specific pathology of coronary artery disease (CAD) has not been recognized. Women with obstructive or nonobstructive CAD associated with traditional risk factors have similar events; no studies have explored both populations in association with genetic markers. Objective To evaluate the DD genotype in overweight menopausal women and its association with CAD and traditional risk factors. Method This cross-sectional study included 356 menopausal women who underwent coronary angiography as CAD assessment. The patients’ DNA was extracted and polymorphisms were detected with a single polymerase chain reaction assay. Two groups were formed based on luminal lesions (normal [n = 134] or pathological [n = 222]) with a cutoff value > 30%, considering overweight and age. The chi-square test, Student’s t-test, and multivariate logistic regression were performed as appropriate (p < 0.05) using the following variables: overweight, diabetes, hypertension, dyslipidemia, smoking status, sedentary lifestyle, and a family history of CAD. Results The mean age of the sample was 63 + 8 years, and the mean BMI was 28 + 5 kg/m2. The DD genotype was slightly more prevalent in the pathological group (30.2% vs. 21.6%, p = 0.079), but this significantly changed when BMI > 25 was considered (33% vs. 18%, p = 0.012). In multivariate analysis with two threshold levels (> 50 and > 60 years), diabetes was significantly associated with CAD in both models (p = 0.021 vs. 0.009) but the genotype was only associated with younger age (p = 0.034). Conclusion These data support an association between atherosclerosis and the renin–angiotensin system in overweight menopausal women that is dependent on the age at which the ischemic event occurs.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021000400411
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021000400411
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.36660/ijcs.20200400
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
dc.source.none.fl_str_mv International Journal of Cardiovascular Sciences v.34 n.4 2021
reponame:International Journal of Cardiovascular Sciences (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
instacron_str SBC
institution SBC
reponame_str International Journal of Cardiovascular Sciences (Online)
collection International Journal of Cardiovascular Sciences (Online)
repository.name.fl_str_mv International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv tailanerodrigues@cardiol.br||revistaijcs@cardiol.br
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