The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!

Detalhes bibliográficos
Autor(a) principal: Rocha,Euclides Timóteo da
Data de Publicação: 2017
Outros Autores: Alves,Wilson Eduardo Furlan Matos, Verschure,Derk O., Verberne,Hein J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Journal of Cardiovascular Sciences (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472017000600533
Resumo: Abstract Cardiac adrenergic imaging has a great potential in a wide variety of clinical applications. Cardiac 123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy has a key role to assess chronic heart failure (CHF) by risk stratifying patients for cardiac events. The mIBG is a norepinephrine (NE) analogue that can evaluate cardiac sympathetic activity by assessing the down expression of β-adrenergic receptor (β-AR) in CHF. Furthermore, 123I-mIBG scintigraphy in combination with other parameters of left ventricular function can be used to identify the best responder for implantable cardiac devices, as well as to assess oncological cardiotoxicity. Despite its usefulness, 123I-mIBG scintigraphy is not widely performed because of the lack of standardization between different institutions. Thus, standardization and validation may contribute to its acceptance in clinical setting.
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spelling The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!Heart FailureMyocardium/diagnostic imagingRadionuclide Imaging3-IodobenzylguanidineSympathetic Nervous SystemAbstract Cardiac adrenergic imaging has a great potential in a wide variety of clinical applications. Cardiac 123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy has a key role to assess chronic heart failure (CHF) by risk stratifying patients for cardiac events. The mIBG is a norepinephrine (NE) analogue that can evaluate cardiac sympathetic activity by assessing the down expression of β-adrenergic receptor (β-AR) in CHF. Furthermore, 123I-mIBG scintigraphy in combination with other parameters of left ventricular function can be used to identify the best responder for implantable cardiac devices, as well as to assess oncological cardiotoxicity. Despite its usefulness, 123I-mIBG scintigraphy is not widely performed because of the lack of standardization between different institutions. Thus, standardization and validation may contribute to its acceptance in clinical setting.Sociedade Brasileira de Cardiologia2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472017000600533International Journal of Cardiovascular Sciences v.30 n.6 2017reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/2359-4802.20170070info:eu-repo/semantics/openAccessRocha,Euclides Timóteo daAlves,Wilson Eduardo Furlan MatosVerschure,Derk O.Verberne,Hein Jeng2017-11-27T00:00:00Zoai:scielo:S2359-56472017000600533Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2017-11-27T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!
title The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!
spellingShingle The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!
Rocha,Euclides Timóteo da
Heart Failure
Myocardium/diagnostic imaging
Radionuclide Imaging
3-Iodobenzylguanidine
Sympathetic Nervous System
title_short The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!
title_full The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!
title_fullStr The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!
title_full_unstemmed The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!
title_sort The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!
author Rocha,Euclides Timóteo da
author_facet Rocha,Euclides Timóteo da
Alves,Wilson Eduardo Furlan Matos
Verschure,Derk O.
Verberne,Hein J
author_role author
author2 Alves,Wilson Eduardo Furlan Matos
Verschure,Derk O.
Verberne,Hein J
author2_role author
author
author
dc.contributor.author.fl_str_mv Rocha,Euclides Timóteo da
Alves,Wilson Eduardo Furlan Matos
Verschure,Derk O.
Verberne,Hein J
dc.subject.por.fl_str_mv Heart Failure
Myocardium/diagnostic imaging
Radionuclide Imaging
3-Iodobenzylguanidine
Sympathetic Nervous System
topic Heart Failure
Myocardium/diagnostic imaging
Radionuclide Imaging
3-Iodobenzylguanidine
Sympathetic Nervous System
description Abstract Cardiac adrenergic imaging has a great potential in a wide variety of clinical applications. Cardiac 123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy has a key role to assess chronic heart failure (CHF) by risk stratifying patients for cardiac events. The mIBG is a norepinephrine (NE) analogue that can evaluate cardiac sympathetic activity by assessing the down expression of β-adrenergic receptor (β-AR) in CHF. Furthermore, 123I-mIBG scintigraphy in combination with other parameters of left ventricular function can be used to identify the best responder for implantable cardiac devices, as well as to assess oncological cardiotoxicity. Despite its usefulness, 123I-mIBG scintigraphy is not widely performed because of the lack of standardization between different institutions. Thus, standardization and validation may contribute to its acceptance in clinical setting.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472017000600533
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472017000600533
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/2359-4802.20170070
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
dc.source.none.fl_str_mv International Journal of Cardiovascular Sciences v.30 n.6 2017
reponame:International Journal of Cardiovascular Sciences (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
instacron_str SBC
institution SBC
reponame_str International Journal of Cardiovascular Sciences (Online)
collection International Journal of Cardiovascular Sciences (Online)
repository.name.fl_str_mv International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv tailanerodrigues@cardiol.br||revistaijcs@cardiol.br
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